Also, don't forget to take it with fat(milk, milk shake, cheeseburger, cheese, oil etc). Atovaquone is a fat soluble chemical. It does not dissolve in water. If you take it with just water, 95-99% of it will go straight through you and into the toilet. When taken with fat, atovaquone dissolves in the fat and the fat is absorbed into the walls of the intestines, carrying the chemical through.