I have had lyme for a very long time. I've had severe pain throughout my body in various forms that come and go but the burning, tight muscles and horrible joint pain has been the real challenge for me as a carpenter. I recently saw a pain specialist who prescribed Lyrica 50mg 3 times a day and it is working so incredibly well!! I don't really know what to think about myself now since I have lived with this ever increasing pain for so long and to now have some real relief, it is so foreign. I have tried so many drugs and was not expecting Lyrica to help but figured I at least have to give it a try and to my extreme surprise it has relieved at least 50% of my burning and sharp pains in my joints and muscles. My Muscles and joints used to crack and pop whenever I moved but that has dramatically decreased. It has made me a bit tired but I always am anyway. If you haven't tried Lyrica you might want to ask your doc about it.