I used Zhang for lyme for 5 months and had to go back on ABX. I had a hidden bartonella issue which could have played a big role in that relapse. When I tried to take Zhang's HH capsule, just in case I had bart, I could not tolerate it. I had really bad insomnia. After taking Levaquin for over a month, there is no problem with the HH capsule. I sleep fine. So maybe the Hh capsule was working before on the BLO I did not know I had. I also could not tolerate some other herbs that cause bladder irritation, another complaint with bart. Now, I am also taking Samento, not the whole Cowden protocol, and I seem to feel an immediate difference in that I have more body pain. In fact the morning has been pretty miserable but I don't know for sure what is causing it. My LLMD told me cat's claw (not specifically samento), teasal root and andrographis are his first choices.