Lack of lyme in the blood would result in a negative blood PCR test. Antibodies can be created against any infectious organism, regardless of where in the body it lives. Lyme is very skilled at evading and suppressing the immune system, such that the body has a hard time developing antibodies. Also, once the body does manage to create antibodies to the Lyme, the bacteria changes the proteins on its outer surface and then the antibodies that were created won't recognize it anymore...this causes the body to constantly need to create new antibodies to the Lyme. But cell-wall deficient and cyst forms of Lyme are immune to antibodies attaching to them (at least, that's my understanding...). Also, it is known that Lyme live in biofilm communities, and biofilms are known to be resistant to the body's attempts at generating antibodies and attacking the bacteria. So when a suppressed immune system, which has an impaired ability to even create antibodies in the first place, is combined with such an elusive and tricky bacteria, the number of antibodies created is likely pretty small. Also, there is another theory that says the antibodies are bound up already (called immune complexes, which is a combination of an antibody and an antigen such as Lyme bacteria or a fragment of Lyme bacteria), leaving very few available free antibodies to attach to the test medium in the lab, thus making the results artificially lower than reality. PCR tests are supposed to get around this, but if the critters are only present in small numbers in the blood stream, then the PCR test is inaccurate too. And something that can make immune complexes circulate in the blood stream without there being very much Lyme itself in the blood is when the bacteria are killed, the body has to get rid of them somehow, and the main way this happens is through the blood stream to the liver (for excretion via bile into the bowel) and kidneys (for excretion via urinary tract).
I hope this helps...take care,
Chronic Lyme Disease, Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, Pancytopenia, chronic malabsorption/malnutrition, etc.; G-Tube; Currently TPN-dependent.
Meds: Zofran, Pulmicort, Heparin (to flush PICC line), IV Ceftazidime (for Pleural Effusion), Colloidal Silver (used topically).