Fatigue can be a side-effect of antibiotics. I experienced this when I was on Cipro - seems I could fall asleep anywhere, any time.
Fatigue can also be a symptom of a herx (die-off) reaction. Detoxing should help this.
Fatigue can also be from the body telling you it is time to sleep so it can repair damage.
Fatigue is a symptom of Lyme/Masters and many of the coinfections.
And it may be a combination of the above.
I hope this helps - take care,
Chronic Lyme Disease, Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, Pancytopenia, chronic malabsorption/malnutrition, etc.; G-Tube; Currently TPN-dependent.
Meds: Zofran, Pulmicort, Heparin (to flush PICC line), Claritin, Colloidal Silver (used topically), IV Milk Thistle, probiotics.