Lab testing to confirm Lyme/Antibiotic-Orimed Urine PCR

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Regular Member

Date Joined Feb 2009
Total Posts : 214
   Posted 6/21/2009 10:38 AM (GMT -7)   
At a recent conference the medical director the Igenex medical director recommends doing "primed PCR urine tests if western blot tests are inconclusive. Antibiotics drive the Borrelia into the bladder where they can be detected in the urine. It is also a good clinical trial as you will see if there is any herxing or symptoms while on or immediately after the antibiotics. Be sure to keep a good diary of symptoms- headache, brain fog, fatigue, aches during these days. Your doctor should call Igenex (1-800-832-3200) so you have the correct forms and containers. There are many protocols used some recommend 3 days of collections or 5 days with 3 specimens sent. Here is a typical protocol:

Take Ceftin 500 mg twice daily with Zithromax 250 mg twice daily and collect urine for 5 days. Collect and send 3 separate urine samples during these days to Igenex for PCR tesing.

Igenex actually recommends repeat testing if initial test are inconclusive ie only one specific band is poistive. If you retest be sure to ask your doctor to check for 31kDa box as this will increase specificity. Your doctor must check this off on the back of the requisition paper or it will not be done ( I didn't know about this for 3 years and I'm a doc). 31kDa is highly specific for Lyme and can help clinch the diagnosis in "iffy" cases. If money is an issue and insurance won't cover repeating western blots- just do the urine PCR with antibiotics as it give both a clinical and lab diagnosis.

Veteran Member

Date Joined Feb 2003
Total Posts : 9208
   Posted 6/21/2009 5:49 PM (GMT -7)   
I had this test done at two different times some time ago, and the results were positive both times.  Thanks for the reminder about this test.

Veteran Member

Date Joined Sep 2007
Total Posts : 2017
   Posted 6/21/2009 5:54 PM (GMT -7)   
I had this done 1x. Igenex took 3 samples of pee 1 each separate day. It was my first fully positive (CDC AND the State of NY) positive LD TEST. I trust them!
Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it's the only thing that ever has.  - Margaret Meade
06/00- I begin to fall apart, 08/01-LD +, 10/01- Igenex and CDC LD positive, 10/02-LD +, 11/03-LD +, 10/07-Bartonella +, CD57=3, koseri IgA +, Morganella +, motgani +,Rocky Mountain Spotted Fever +, Typhus +, Klebsiella pneumonia +, Proteus miabilis +, Citrobacter i IgA +, Hafnia alvai IgA +, NKC4 +, Interleukin 4 (IL4) +, IL8, Immunobillin (IM01) +. 
Rx's 06/15/09: Wellbutrin 300, Paxil 60, Xanax 5, Acidophilus, Lyrica 600, Levaquin 500, Diflucan, Invanz IV, possibly Gammaglobulin, Flagyl, HBOT  
"How much more can I take?", song

james from missouri
Regular Member

Date Joined May 2009
Total Posts : 432
   Posted 6/21/2009 6:16 PM (GMT -7)   
so this is the best way to go then? i'm curious. i want to be 100% sure on my test results, for some reason it comes back neg, i won't be happy..

Veteran Member

Date Joined Feb 2003
Total Posts : 9208
   Posted 6/21/2009 6:24 PM (GMT -7)   

James, there is no completely reliable test for Lyme disease.  Some people who have Lyme do not have a positive test.

The Western Blot test lists a series of numerical bands with a + - or IND rating after each one.  The CDC requires several bands to be positive for the test to be positive.  Many people who have Lyme do not have this many bands.  Lyme doctors often look at which bands are positive--some are specific for Lyme. 

I think it is a good idea to start with at least the Western Blot.   You could also do the urine test if your doctor recommends it.

Regular Member

Date Joined Feb 2009
Total Posts : 214
   Posted 6/21/2009 6:34 PM (GMT -7)   
Yes this should only be done if western blot is inconconclusive. This is usually done with a repeat western blot. Remember Lyme is a clinical diagnosis... Many people are unable to form a reaction to the infection.... This is why this disease is such a political mess...

Veteran Member

Date Joined Apr 2009
Total Posts : 1304
   Posted 6/21/2009 6:41 PM (GMT -7)   
Can you please tell us approximately what this costs?
Lyme in NC in 1971? Suspect TBI: Fully engorged tick followed by high fever and tonsillitis. Follwed by , lumps on neck,  chronic tonsillits w/ constant low grade to recurring high (104) fevers, severe unexplained neck stiffness and acute neck pain.   Followed by tonsillectomy, urinary tract infections, miscarriage, appendicitis while pregant, chronic severe back pain. Followed by depression, mild anxiety, mitral valve prolapse, and hypglycemia.  Was this a TBI??
Bit again couple of times, lyme suspect bite Mother's Day 2007. Bite, symptoms, lyme specific antibodies on the most lyme specific band of all = 39 IgG.  Still awaiting appt w/ LLMD.

New Member

Date Joined Dec 2013
Total Posts : 2
   Posted Yesterday 10:16 AM (GMT -7)   
I'd also like to know what the costs are for "primed PCR urine tests"
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