Misc lab work questions

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+Lyme
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   Posted 7/15/2009 8:34 PM (GMT -7)   
I apologize for butting in here w/o properly responding to others' posts.  But I've had a bit of a meltdown.  No need to say 'sorry', I promise, but I have a few questions. And maybe, hopefully these will help others, if some of you understand these lab results.
 
First, the past couple days I've experienced kind of sudden worsening of some symptoms: neck, (knees are a little sore, but hadn't bothered me before), sore ankles and feet;  and mostly these: cognitive stuff, depression, ever increasing fatigue.  The cognitive has caused me problems at work. The depression hit hard and fast and I almost hit rock bottom.  It is improved a little this evening.  Total body feels stiff and as if all muscles are tensing and contracting. Increased hot flashes and it seems they come within an hour of taking doxy, but timing is not always the same.
 
Do you think this is more likely a herx or possibly a new infection (tick bite 2 weeks ago). Can one herx on as little as 200 mg/day of Doxy?  Would cognitive, depression stuff get worse w/ a herx?
 
Labs: If, as the lab interpretations say, it is perfectly normal for these to be high and out of range, then why would a Dr order  the tests?  Does anyone know about these? I'm gonna look them up, but assuming I will find the same interpretations as what is in the lab report.  This lab is Quest
 
Parvovirus B-19:  My  IgG  is 5.4 and high range begins after .9 -- seems pretty high, but notes say IgG persists for many years w/ lifetime immunity. It says this only signifies exposure.
 
EBV VCA IgG and EBV EBNA IgG are high.  Both are over 5, w/ > 1.1 being positive.  Interpretation says tests are suggestive of past virus infection. (had mono in high school -- would that account for both? along w/ how far out of range?)
 
Herpesvirus 6 IgG is 1.8 (high begins w/ 1.2)
 
Babesia Microti IgG is 1.32, w/ high range beginning at 1.2.  It first says it only means I was exposed. Then it says that levels greater than or equal to 1.10 are detected in acute phase patients.
 
I do not understand how to read the Rocky Mt.  They were testing for reflex to titers.  They call the tests negative, and gave the reference ranges, but I can't tell how to find my result.  Do they just not report my levels if this test is negative?
 
They did not even do the WB the Dr. ordered -- the lab tech didn't know what it was, and even after I explained how to order it, looks like it did not get done.
 
Sed rate of 6 is really good, isn't it?
 
Rheum profile: note says  a delay in this testing and reporting, unable to reach Dr. by phone, and for him to call CSR.  Strange -- this same lab neglected to test this when my PCP ordered it, too.
 
Any knowlege and/or experience w/ any of these would be sincerely appreciated.
 
Still awaiting results of CD57.
 
 

Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day


Stunned123
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Date Joined Apr 2009
Total Posts : 114
   Posted 7/16/2009 5:31 AM (GMT -7)   
I am probably not going to be a lot of help on the viral tests. I know that IGG usually means a "past exposure" that you have developed anitibodies to. However, you seem High on all of them. Hopefully someone who is more familiar can chime in.

I like you had my Babesia AB drawn through Quest. Mine came back High @ 1:2. My LLMD feels that this is the Lyme messing with this result rather than a true co-infection.

Your sed rate is ok. I had that drawn through Quest as well. Mine was 1. Normal range is 0-20 mm/hr. I hope this has helped you somewhat.
I wanted to also add that I am sorry you are having some bad symptoms.  I can truly relate.

Heather

+Lyme
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Date Joined Apr 2009
Total Posts : 1304
   Posted 7/16/2009 6:25 AM (GMT -7)   
Thank you for your input, Stunned. I appreciate it!

Are you saying that your LLMD believes that you don't really have babs?

Looking up labs, one thing I found was that one of the EBV tests indicates past infection and the other indicates current or recent infection.

Does anyone know how lyme and mono relate or do not relate? Does or can lyme cause mono? Or does Lyme just mess w/ mono results?

Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day


Stunned123
Regular Member


Date Joined Apr 2009
Total Posts : 114
   Posted 7/16/2009 6:34 AM (GMT -7)   
Hi,
He believes that I do not have a Babs infection and that the Lyme is causing the borderline High result. I am going with him at this point.

I know that Lyme can re-activate previously dormant viruses for sure. I think we have seen this in so many people. So even though Lyme does not "cause" Mono, it can most definitely re-activate a past infection. This sucks huh? LOL!

I hope someone more knowledgeable can help with a more in depth response.

+Lyme
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Date Joined Apr 2009
Total Posts : 1304
   Posted 7/18/2009 12:23 PM (GMT -7)   
Gracie's Mom -- hey, thanks for this response and sorry to take so long to reply! Haven't been able to keep up on here and I missed your post!
 
I haven't seen my LLMD yet to go over these results-- won't see him til July 30.  He's the one that ordered these tests, so surely he will be able to explain them to me.
 
What you said about the viruses and your daughter seems to make sense.  I cannot even imagine what all you and your daughter have been thru! I do not know how you have done all that you have done!
 
On the babs -- the Dr didn't deny babs -- he just hasn't seen these results yet because Quest mailed his test results to the wrong place!  I've re-read the babs interpretations on the test and looks certain that my infection is 'acute' as opposed to 'past'.
 
I guess my questions, more succintly are:
 
I'm assuming Doc is checking out my immune system (no CD57 results yet), right?
 
Do the high, 'out of range' readings show these particular antibodies are all present, as they should be w/ a strong immune response?
 
Or do the high, 'out of range' readings show my immune system to be compromised?  And so, are these infections live infections? I do not want them!!
 
Gracie's Mom, over your mountains and along your paths, we will figure all this out!  Your response was very helpful to me and has given me some new ideas for research.  Thanks!

Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day


CajunGrl
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Date Joined Mar 2009
Total Posts : 4717
   Posted 7/18/2009 7:17 PM (GMT -7)   
Lyme,

Usually, and I say "usually", your immune system is compromised and that is why you are picking up these viruses. Your titers can be high and out of range but it depends if it is an accute or past infection whether they will treat you or not. Does that make sense?

I just wanted to chime in. Gracies Mom may be able to shed more light on this.
I have Lyme Disease; Lyme Disease DOES NOT have ME!

**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum


+Lyme
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Date Joined Apr 2009
Total Posts : 1304
   Posted 7/18/2009 7:38 PM (GMT -7)   
Yeah, CajunGrl, I see what you are saying and makes perfect sense. There's no treatment for mono anyway, besides getting plenty of rest and taking care.

I've been researching these viruses and tests all day and have noted that my labs show current and/or reactivated infections. Not necessarily 'acute', except for the babs. But my antibody reactions are pretty high from what I have learned. I am hoping that treating the lyme will help boost my antibodies and that I will kick these viruses. I also think LDN might help, if I can get my greedy hands on it....

Thanks for the add'l input. Between all of us, we will certainly get this figured out!

Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day


CajunGrl
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Date Joined Mar 2009
Total Posts : 4717
   Posted 7/18/2009 7:47 PM (GMT -7)   
Did you have HHV6 too? My gosh, that virus was horrible. It felt like I had the flu but it was 10x's worse. My titer wasn't high enough to get treated for it so it had to "run it's course". Although, I didn't agree with that and thought I should have been given something.
I have Lyme Disease; Lyme Disease DOES NOT have ME!

**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum


+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1304
   Posted 7/18/2009 7:58 PM (GMT -7)   
Yeah, CG, my labs show I've got HHV6 too. I've got mono, parvovirus, HHV6, and Babs. Sheesh, no wonder I'm so freaking tired!

Gracie's Mom -- I found your old post in which you posted almost identical lab results for your daughter.


Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day

Post Edited (+Lyme) : 7/18/2009 10:06:10 PM (GMT-6)


+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1304
   Posted 7/18/2009 9:54 PM (GMT -7)   

OH, it's gonna happen alright, GM, it's gonna happen, no doubt.

AND, thank you so much! And likewise to you!

I just want to say this about the CD57 test. Dr said he believes it is more accurate than the WB, esp if the WB came from Quest, and if lyme infection has been long term, which is difficult w/ the WB. My understanding is that the CD57 can help give an idea of how long the lyme has persisted. It can also, likewise, be helpful in determining when someone is getting better. He said that if treatment is stopped after the CD57 improves, but not completely normal, then a person cannot be considered cured and recurrence is likely.

I am very anxious for the results of this test!

 
And, yup, I realize the babs that showed may be a trial to get rid of. AT least it showed up in my labs, tho.


Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day

Post Edited (+Lyme) : 7/18/2009 11:10:02 PM (GMT-6)


CajunGrl
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Date Joined Mar 2009
Total Posts : 4717
   Posted 7/18/2009 10:04 PM (GMT -7)   
Lyme,

My doctor likes going by the CD57 results too. He told me that there are only 3 things that can suppress your immune system and that is Lyme, syphilis and AIDS.
I have Lyme Disease; Lyme Disease DOES NOT have ME!

**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum


+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1304
   Posted 7/18/2009 10:07 PM (GMT -7)   
Well, GM, I don't think I'm going to discover anything new -- at least for awhile. But you all must know that if I find stuff, I will post it. From LDN to grapefruit and olive oil. (or was that another oil?)

WELL, since I have MONO, I'd better hit the hey and get a good nite's sleep......

Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day


+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1304
   Posted 7/18/2009 10:12 PM (GMT -7)   
WEll, CajunGrl, those are very comforting thoughts.................................................. NOT.

Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day


CajunGrl
Veteran Member


Date Joined Mar 2009
Total Posts : 4717
   Posted 7/18/2009 10:27 PM (GMT -7)   
LOL, I'm sorry Lyme! I didn't mean to scare you. I thought you had these tests done already?
I have Lyme Disease; Lyme Disease DOES NOT have ME!

**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum


+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1304
   Posted 7/19/2009 8:21 AM (GMT -7)   
CajunGrl, I started w/ one set of labs from my PCP awhile back, in which we saw the lyme antibodies and my thyroid low enough to treat. He had also ordered other stuff -- at least 2 tests the lab did not complete. And I now have a new set of lab work ordered by my LLMD. I note at least 3 other tests that HE ordered that they did not complete.

I have really lost my faith in labs! Everybody MUST request copies of their labs and go over them themselves!

Anyway, yeah, I got a little scared about the HHV6. Actually, I'm pretty upset about all the viruses, but hoping my Dr. will have expected these results (or something?) After all my research yesterday, I have seen all of these viruses linked to CFS and MS. In only 1 piece did I see Lyme mentioned, but feel certain that is because the fact that it suppresses the immune system is only fairly recently been known. Please correct me if I'm wrong.

So I don't know if Dr is trying to build a case on lyme, or trying to rule out other diseases. We will find out! It seems, tho, that all the similarities w/ Gracie's Mom's daughter, he is building a lyme case. I just don't think anyone knows yet how or why all these are intertwined. No surprise, since there's still so much debate over MS and CFS as well.
 
And I'm sure it's entirely possible that he ordered these tests to learn what we may or may not be up against. Because in my research yesterday,  my results indicate current infections. I was careful w/ that because I was preparing to answer my parents.  Others here have had these tests, and perhaps others who haven't, might want to. It will be 2 more weeks, but I will be sure to post what I learn from LLMD on these.

I think you are possibly confusing the syphillis reference to band 41 on the WB, possibly? Because syphillis is also a spirochete, I believe it can cause a positive band 41. I'm not seeing it connected in any way to the CD57 or the immunosuppressing diseases I've looked at.

On the CD57 (still waiting), from what I've read, altho it is a measure of natural killer cells, it seems to apply pretty much to Lyme only. I've seen it mentioned along w/ AIDS, but I've also noted that AIDS patients watch their CD4 T cell count, and CFS patients watch their CD56 count. There are other diseases that suppress the immune system, but it appears that only Lyme suppresses this particular set of killer cells. That is my understanding anyway. I will be sure to ask my LLMD, but meantime, here's a little piece that's easy to understand:

http://sci.tech-archive.net/Archive/sci.med.diseases.lyme/2007-04/msg00280.html


Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day

Post Edited (+Lyme) : 7/19/2009 9:38:33 AM (GMT-6)


CajunGrl
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Date Joined Mar 2009
Total Posts : 4717
   Posted 7/20/2009 2:40 AM (GMT -7)   
Hey Lyme,

You go girl! I like how you research everything. That's the only way to find answers for yourself. I may have gotten the syphillis reference wrong. This was back in 2007 so I may be getting things confused. My brain has not be great lately either. I feel like I have moosh in there.

I guess that's why I was tested for syphillis since my band 41 was positive. That does make since.

Please keep us updated on everything. You keep my brain working. I need that right now.
I have Lyme Disease; Lyme Disease DOES NOT have ME!

**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum


+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1304
   Posted 7/20/2009 7:25 PM (GMT -7)   
CajunG, crack me up. Yeah, I'm goin..... right..... noooooot...... Hope you didn't take me to be Little Miss Smarty pants , cause I've certainly asked many more questions than I can answer! I also hope that all of us, together, can get down to some answers!


Suspect TBI in 1972.  Attacked tonsils (recurring high fevers, constant low grade fevers, chronic tonsillitis) , pregnancy (miscarraige), appendix, heart (mitral valve prolapse), hypoglycemia, depression, chronic acute neck and back pain.  

Next suspect Mother's Day 2007.  Diagnosed w/ Lyme and Bart June 2009. (awaiting more test results)

In treatment for recurrent depression, anxiety, low thyroid.

Bit again 7/1/2009, began Doxy 200 mg /day

Post Edited (+Lyme) : 7/20/2009 8:51:42 PM (GMT-6)


rosesinjanuary
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Date Joined Oct 2007
Total Posts : 748
   Posted 7/20/2009 7:26 PM (GMT -7)   
Hi sorry you are so sick with time and patience I believe you will get well or at least much much better. I got the lyme rashes in 96 fell sick a little after and was treated for maybe up to 3 years ago? ( memory sucks) Anyway I still get sick once a month around right now, the reason I know is I was fortunate enough to have written dates in my journal so I looked through it and right around now I get symptoms usually they are not real bad but this one is hitting kinda hard head back shoulder knee sore throat incredible fatigue I am sure I felt just like Dorothy in the wizard of oz when that witch put her under the poppy sleep spell. I was done this afternoon I had had the farrier out and I picked up his back foot and pain seared from my low back up and I could not hold his foot, talk about a wimp but usually I am fine this is just an incredibally long way to say that yes even without the use of an antibiotic at least for me one still can flare at a quite predictable time. Hang in I so remember those days (too bad I can't remember anything else, just kiddin, kinda) I found darvicot to be the only med that could touch the pain, hang in there it will get better. oh also before these episodes I start to twitch my left side of face has been playing jumping jacks now for a few days and I might get a litttle manic in behavior before I get sick lisa

Post Edited (rosesinjanuary) : 7/20/2009 8:31:13 PM (GMT-6)


CajunGrl
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Date Joined Mar 2009
Total Posts : 4717
   Posted 7/20/2009 8:02 PM (GMT -7)   
Lyme,

No way did I take you as being a smartypants although I do think you are smart. I love reading your post because I either learn something new or get reminded about something I had forgotten. There is so much to learn with this disease that it can be overwhelming at times. I am here if you need me or to correct me, haha!
I have Lyme Disease; Lyme Disease DOES NOT have ME!

**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum

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