I've had my PICC since 6/30/08 and the biggest problem I've had with it is that it occasionally gets out of position (stuck against the blood vessel wall) and won't give blood return for the routine blood draws. When that happens, I go get it replaced and all is well again. But I've only had to do this twice.
So instead of showering, I take sponge baths, and wash my hair in the sink. The fatigue is a much bigger problem for me than bathing with the PICC.
Yes, the most important thing about having a PICC or midline is good protocol for care of the line (flushing properly, etc.) and the site (dressing changes, keeping the site dry, etc.). Using as aseptic as possible technique for accessing the line is best - Husband and I use lots of alcohol swabs each week, for example.
Chronic Lyme Disease, Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, intermittant pancytopenia, chronic malabsorption/malnutrition, etc.; G-Tube; Currently TPN-dependent.
Meds: Pulmicort, IV Ceftazidime, Heparin (to flush PICC line), Claritin, Domperidone, Colloidal Silver (used topically), probiotics, homeopathy.