Western Blot: IgG Positive IgM Negative??

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New Member

Date Joined Aug 2009
Total Posts : 6
   Posted 9/5/2009 10:36 AM (GMT -7)   
Can anyone explain this result beyond my doctor's words: "You had Lyme at some poijnt, but the infection is presently inactive." He stopped the abx. And I still have symptoms but to a lesser extent---it seems. Could the abx have been responsible for the IgM negative? I took the test 10 days into the 3 week regimen.

I thought i would be easily able to research this result but i cannot find anything on it. Thanks for any response.

james from missouri
Regular Member

Date Joined May 2009
Total Posts : 432
   Posted 9/5/2009 10:45 AM (GMT -7)   
i'm lost also on the IGG.. i had 4 bands positive with 1 +. but the IGM was neg.. my question is, like stated above.. if the IGG is positive but the IGM is neg, does that mean the lyme is in remission?

Veteran Member

Date Joined Apr 2009
Total Posts : 1013
   Posted 9/6/2009 12:10 AM (GMT -7)   
My neuro and ID both said IgM means active as in new infection and IgG is old exsposure that isnt active at the time. but if your positive on either of the 2 you have lyme. this is just how i understand it. i may be wrong . its happened b4..LOL
still looking for answers.
Remember that advice is free, its your choice what you do with it.  :)

Veteran Member

Date Joined Aug 2007
Total Posts : 4399
   Posted 9/6/2009 4:11 AM (GMT -7)   
The WB is not a perfect test. I think the determination of whether Lyme is currently active or not needs to be made in light of the positive IgG result (exposure at some point to Lyme) and current clinical symptoms. It is my opinion that if you have symptoms consistant with Lyme/coinfections that can't be explained by something else, then the Lyme/coinfections is/are likely to blame and thus treatment should be continued. This is purely my opinion - I am a fellow patient, not an MD.

Good luck,
Chronic Lyme Disease, Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, intermittant pancytopenia, chronic malabsorption/malnutrition, etc.; G-Tube; Currently TPN-dependent.
Meds:  Pulmicort, IV Ceftazidime, Heparin (to flush PICC line), Claritin, Domperidone, Colloidal Silver (used topically), probiotics, homeopathy.

Veteran Member

Date Joined Apr 2009
Total Posts : 1304
   Posted 9/6/2009 7:48 AM (GMT -7)   

I am no expert or Dr either.  But I believe it was Dr. Burr who said that generally (nothing is always the sam in Lyme), an IgM + will become IgG+ in 3-4 months.  I do not know exactly what this means, but he said nothing about the infection no longer being active.  I believe IgG just generally indicates an older infection.

I stand to be corrected if I'm wrong, but this is what I've found when searching interpretaions of the WB.


Bit 1972: Acute and chronic tonsillitis, UTI, miscarraige, appendicitis, hypoglycemia,  chronic neck pain w/ crushed vertibrae, chronic severe back pain, mitral valve prolapse, depression, resolution?
Bit Mother's Day 2007: Lyme, Babesia microti, hypothyroidism, EBV, HHV6, Parvovirus B19, low adrenals &misc other hormones, depression, anxiety, more of the above.
What don't these nasty bugs cause? 
CD57= 60, so we're in pretty good shape.

Regular Member

Date Joined Jan 2006
Total Posts : 312
   Posted 9/6/2009 7:51 AM (GMT -7)   
If you have symptoms of lyme with those test results, then you most likely have it actively and its a more chronic stage as of this point.

UC/Chrons - Feb 2004
Panic Disorder/depression - June 08
Lyme Disease/Babesia - June 08 
Dysplastic Nevus Syndome - birth
Currently: Treating Lyme/Babs
Drugs: 6mp 50 mg|Paxil 50 mg|Klonopin .25 mg|Trazodone 50 mg|WellButrin|Zithromax,Malarone,Flagyl|PRN Nucynta/Percoset

New Member

Date Joined Aug 2009
Total Posts : 6
   Posted 9/6/2009 9:39 AM (GMT -7)   
I guess I was kind of wishing the IgM negative countered the IgG positive, but I guess the reverse might more likely be the case. That is: an IgG positive can be past and present.

This is interesting because my symptoms started this summer. But again as one responder said the WB is not fully accurate, and that different tests can offer different results.

In any case, thanks for all your responses. They are helpful.

Desperate mama
New Member

Date Joined Apr 2013
Total Posts : 8
   Posted 5/2/2013 11:22 AM (GMT -7)   
My igm is all positive with four markers neg llg but anouther test says lyme llg/lgm test high 1.27 normal 0-.90 everyone says there all false positives because I have been sick for so many years

Desperate mama
New Member

Date Joined Apr 2013
Total Posts : 8
   Posted 5/2/2013 11:24 AM (GMT -7)   
Does anyone know of any Lyme literate drs in Utah

Forum Moderator

Date Joined Nov 2006
Total Posts : 1952
   Posted 5/2/2013 11:51 AM (GMT -7)   
Hi Desperate Mama,

I'm so sorry you're sick, but I am glad you were able to find us! How long have you been sick?

You might want to start a new thread for your question so that more people can see it and help.
"If you can't fly then run, if you can't run then walk, if you can't walk then crawl, but whatever you do, you have to keep moving forward." -Martin Luther King

Lyme Disease Forum Moderator
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