My understanding is that a 41+ indicates an infection w/ a spirochete. The spirochetes may be Lyme, dental disease, or syphillis. I have not yet found another infection/disease that will cause a positive 41. It is possible that there are some that we don't know about
It seems that it should not be very difficult to diagnose or rule out the other infections. If that is possible, (ruling out the other diseases) then the 41 would indicate Lyme.
Positive band 41 does appear to be esp significant,if it is accompanied by even one single positive lyme species specific band.
My understanding from what I have read regarding the significance of band 41 in Lyme:
41 is often the first significant band to show when one has been infected w/ Lyme, as well as the others listed above. So this band (41) does not necessarily indicate Lyme, altho it does indicate a spirochetal infection. If this infection happens to be Lyme, and after enough time has passed, other lyme specific bands should then be appearing (on the WB) which should lend serious evidence that your infection is Lyme.
It is also very possible, from both my experiences on this forum, as well as my reading material on this, that I can state that Band 41 is very significant, even when it does not appear to indicate Lyme.
I apologize -- I am experiencing a true cognitive, neuro lyme day today. I'm having difficulty telling you what I'm trying to say....
If you only have a positive band 41, then you and your Dr need to do some serious research. But if you have a positive band 41, along w/ any positive species specific band (s), then your positive 41is aiding you and your Dr w/ a diagnosis of Lyme.
Again, sorry, if I'm not making sense, accept my apologies and delete my posts! And I will take no offense because I had to struggle while writing this
Bit 1972: Acute and chronic tonsillitis, UTI, miscarraige, appendicitis, hypoglycemia, chronic neck pain w/ crushed vertibrae, chronic severe back pain, mitral valve prolapse, depression, resolution?
Bit Mother's Day 2007: Lyme, Babesia microti, hypothyroidism, EBV, HHV6, Parvovirus B19, low adrenals &misc other hormones, depression, anxiety, more of the above.
What don't these nasty bugs cause?
CD57= 60, so we're in pretty good shape.