Ya... I've been on abx for way too long, i would say I've been virtually symptom free for the past 2 months now. But as soon as I "test the waters" sort of speak and come off antibiotics so miss a dose, the symptoms come right back!!! It's frustrating.
I think what happens with Borrelia, is persistence, not necessarily resistance. It is a very slow growing germ, but I think it relapses because some germs go dormant during abx treatment! My theory is that we want them to resume their normal cellular metabolism and wake them up again so we can effectively kill them.
Also pulsing abx gives your body time to repair, mobilizes the immune system, and as soon as the germs start their metabolism up again we can stun them with abx and the immune system can do it's work.
That's what tetracyclines like our doxycycline and minocycline do. They bind reversibly to the 30S ribosome which takes RNA and transcribes it into protein. But if you keep the tetracycline on them some of them freeze up and go metabolically inactive only to become active again later. If we give them abx when they are in the middle of a process like reproduction it can kill them.
I don't have a regimen for pulsing yet. I took yesterday evening off all abx (except my Septra DS which is for Bartonella). And the symptoms came back big time, all my remaining symptoms are brain symptoms! The infection lingers in my brain!
So I gave it a shot of 200 mg minocycline and 500 mg tinidazole and totally knocked it back out, I think I actually had a little herx by doing that. No symptoms now since that dose I took in the morning.
But 200 mg minocycline is too much at once!! It gives me a little headache after. And taking so much tinidazole scares me because it could cause DNA damage!
I think the ultimate plan is to go 100 mg minocycline and 250 mg tinidazole every second day. These are also MUCH better tolerated doses. I will just take them on an empty stomach.
That will lower levels down enough so they will resume metabolism, and maybe even come out and think it's safe, then hit them.
I see lots of "cures" done by pulse dosing. Lyme is such a slow growing germ that abx resistance actually is not at all an issue. The issue with lyme is persistence!
Post Edited (LymePickle) : 6/8/2014 6:34:03 PM (GMT-6)