Plaquenil is more specific in its effects on the immune system, therefore the entire immune system is not disabled by it. Prednisone, on the other hand, shuts down a major component of the immune system (by interfering with fatty acids, hormones, etc.) and also suppresses the adrenal gland...thus, steroids have a much greater impact on the immune system (and many other things in the body...skin, eyes, joints, bones, etc.).
Chronic Lyme Disease, Chronic Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, etc.; G-Tube; Currently trying to wean off TPN.
Meds: Pulmicort, IV Ceftazidime, Heparin (to flush PICC line), Claritin, Domperidone, Colloidal Silver (used topically), probiotics, Milk Thistle, Ailanthus, homeopathy.