I am new to this forum. I have POTS and IC. I was dx with POTS in 2006 but have had bladder problems since 1989. I was just dx with Lyme in December. I did two months of doxy and then took 6 weeks off (lyme md change) and now am back on doxy and rifampin. I would love to hear from other folks with POTS or IC. Both illness require so much fine tuning of medication, fluid, salt, diet etc and often what helps one hurts the other. My bp was out of control this week and now my bladder is miserable. I just started the rifampin and am worried it might irritate my bladder. Thanks!