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Nicky D
Regular Member

Date Joined Jun 2009
Total Posts : 361
   Posted 4/20/2010 5:26 PM (GMT -7)   
I just thought I'd let anyone who was interested know- I have been on antibiotics since the beginning of August. I have seen lots of improvement in my symptoms, but not so much in the tendon and joint pain. So my doctor started me on lumbrokinase, which is apparently an earthworm enzyme that can break through biofilms. Anyway, I have been on it for about a week, and I am having a stronger reaction to it than I did to Flagyl! I was a little on the fence, to be honest. I thought it sounded kind of weird (earth worms? Really?), but there seems to be something to it. It's not fun right now- I'm in a lot of pain- but I'm optimistic that this is a good sign, and not a bad one (and I know not everyone thinks you need a die off reaction, but at least you know that something is happening, right?)

Has anyone else heard of this? What have you heard?


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Date Joined Sep 2007
Total Posts : 2017
   Posted 4/20/2010 7:16 PM (GMT -7)   
Welll - I always said I would stand on my head in a corner and eat worms if I thought it would help!
A small group of committed citizens can change the world-it's the only thing that ever has.-M. Meade

Veteran Member

Date Joined Aug 2007
Total Posts : 4399
   Posted 4/21/2010 7:01 AM (GMT -7)   
For the vegetarians out there, there is another enzyme that can do the same thing but which is derived from soy, called Nattokinase.
Chronic Lyme Disease, Chronic Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, etc.; G-Tube; Currently weaning off TPN.
Meds:  Pulmicort, IV Doxycycline, Heparin (to flush PICC line), Claritin, Singulair, Domperidone, Colloidal Silver (topically & nasally), probiotics, Liver support herbs, Ailanthus, digestive enzymes, homeopathy.

Regular Member

Date Joined Jun 2006
Total Posts : 60
   Posted 4/21/2010 8:17 AM (GMT -7)   
Hi Nicky D - my family all take Lumbrokinase.  We started it because of the tendency of Lymies to have "thick blood" and it works as a blood thinner, too.  I learned afterwards that it breaks down the biofilms, which is great, too!  It is supposedly 2.5 to 10 times stronger than Nattokinase, the soy based version. 
From what I have read, thinning the blood helps with all kinds of things, I took this from the Digital Naturopath website page on Hypercoagulation (Thick Blood).
  • When fibrin coats the walls of the capillaries, nutrient and oxygen delivery to muscle, nerve, bone and organ tissue is compromised.
  • The fibrin coating the capillaries and producing thick blood can make virii and bacteria less accessible to treatment.
  • Thicker blood is harder to pump.
  • By depriving the gut of proper nourishment, hypercoagulation may be a major factor in IBS.   If the bowel is deprived of blood, cells will die too rapidly.
  • The endothelial cells lining the capillaries are the source of heparans, the body's natural blood thinners. When fibrin coats these cells, the heparans cannot be released, reducing the body's ability to dissolve the fibrin.

Here is a link to the full article:

So I am hoping for good results, we have only been on it a few weeks.  I hope you have good results, too!


DX in 1994 - SLE, myositis, firomyalgia, sjorgens, raynaud's, elevated ANA, lymphadenopathy.

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Date Joined May 2007
Total Posts : 35859
   Posted 4/21/2010 5:55 PM (GMT -7)   
JELAINEP said...
Welll - I always said I would stand on my head in a corner and eat worms if I thought it would help!

Seems to me that if you were standing on your head, it would make it harder to swallow those worms!! smhair
It's been said:LD patients can be as ill as people w/ congest. heart failure & in as much pain as post-op patients.

Veteran Member

Date Joined May 2006
Total Posts : 1477
   Posted 4/21/2010 9:36 PM (GMT -7)   
I have been doing heparin shots twice a day and KNOW it is the key to the horrible migrains I was having.

But I would rather take the earth worms too than keep shooting my belly twice a day.

THICK blood is a major problem for lymers. The heparin really made a difference .

keep posted on how this worm thing goes
hep c , lyme
Dad has lyme

Veteran Member

Date Joined Jul 2005
Total Posts : 570
   Posted 4/21/2010 9:55 PM (GMT -7)   
Razzle said...
For the vegetarians out there, there is another enzyme that can do the same thing but which is derived from soy, called Nattokinase.

Yeah, I had high fibrin in my blood and Nattokinase took care of it. My own GP, who I occasionally go to, has heart problems. His heart doctor wanted him on Coumadin but he refused to take it. He told his heart doctor that if the Nattokinase didn't bring his blood level where it should be he'd take the Coumadin. His heart doctor wasn't too thrilled about it but two months later when he went to get his blood tested it tested perfectly fine. His heart doctor had never heard of nattokinase before and still doesn't agree with his patient (his peer) about not taking Coumadin, but he admits the stuff obviously works! Interesting.

I take that along with Transformation Protease recommended by Dr. Jernigan. Great stuff!

TPPTM Protease is a proprietary blend of highly active proteolytic enzymes with a wide range of pH stability. Proteolytic enzymes taken orally under certain conditions have been shown to be absorbed in substantial quantities into the blood.1,2,3 Once in the blood circulation, the enzymes in this blend bind to serum proteins, particularly alpha 2-macroglobulin (a2M), and impart immunomodulatory benefits.4 One of the best-established functions served by the oral proteases in Tzyme blend is in the maintenance of normal blood flow. This is accomplished by breaking down blood clots (fibrinolysis) and platelet aggregation within blood vessels and breaking down excess extra-vascular plasma proteins as in edema. TPPTM Protease will also enhance the hydrolysis of food proteins for enhanced bio-availability of amino acids.

Modulation of the Immune System: As a result of their coupling to 2M, TzymeTM proteolytic enzymes exhibit an increased binding of several very important cytokines (hormones-like molecules which have a powerful influence on immune cells) such as Transforming growth factor-beta (TGP-B), and Tumor Necrosis Factor-alpha (TNF-a).5 Studies have indicated that oral hydrolytic enzymes affect cytokine synthesis and modulatory effects.6 For instance, TNF-a synthesis, which is a necessary step in host defense against tumor cells,7 is impaired when experimentally inactivated oral proteolytic enzymes were used.8

Thus, active, GI stable and functional oral enzymes that are absorbed in the blood stream can provide therapeutic applications. In addition, studies have shown that oral proteolytic enzymes increased the tumoricidal and cytotoxic activities of polymorphonuclear neutrophils.9

Bromelain, an important addition to the TzymeTM Protease Blend, is a protease derived from the pineapple plant. It has been used for many years as a digestive aid, anti-inflammatory and burn debridement agent. Its actions help to prevent swelling/edema, promote smooth muscle relaxation, inhibit platelet aggregation, and enhance antibiotic absorption. Bromelain is also used in cancer treatment, ulcer prevention, sinusitis relief, appetite inhibition and shortening of labor.10,11 Proteolytic enzymes administered orally improved the survival time, the hematological parameters of spontaneous lymphoblastic leukemia in rats, and the metastasis and survival time of mice with Lewis lung carcinoma.12

Several hypotheses have been put forth as to the mechanisms by which proteolytic enzymes modulate the immune system to control and eliminate tumors. Some studies indicated that proteolytic enzymes selectively remove some adhesion molecules such as CD4, CD44, B7-1, ICAM-1, B7-2, CD45RA, CD6, CD7, E2/MIC2, and Leu81/LAM 1 from cell surfaces.13,14,15,16 According to Hale et al.16 the removal of these surface molecules has markedly enhanced CD2 mediated T-cell activity.

Some studies have implied that by removing the glycoprotein CD44, some proteases help control the tumor growth of certain types of cells. This selective removal of some mediator proteins, and the regulation of cytokines19,8,6,5 constitute some factors by which proteolytic enzymes are thought to modulate the immune system and act as biological response modifiers.


Impaired Kidney Function - Glomerulonephritis: In this disease there is a build up of protein in the basement membrane of the glomeruli of the kidneys. Fluids must pass through this basement membrane in the initial phase of the filtration of the blood by the kidneys. Recent research using an animal model of this disease "lends further support to the concept that enzymes capable of degrading immune complexes in situ can ameliorate glomerulonephritis".17

Heavy Metal Toxins - Heavy metals such as lead (Pb) and mercury (Hg) exert their poisoning effect by binding to ionizable or sulfhydryl groups of proteins, including vital enzymes. Once these metals bind to an essential functional protein, such as an enzyme, they denature and/or inhibit it. This interaction of heavy metals to proteins can lead to degenerating diseases, nerve damage or even death.

When taken on an empty stomach, it should be noted that protease is readily taken up into the mucosa cells of the intestine and passed into blood circulation. Clinical observations have noted that upon high intake of TPPTM Protease, heavy metal concentrations have been significantly decreased in the blood.


Nicky D
Regular Member

Date Joined Jun 2009
Total Posts : 361
   Posted 4/22/2010 7:16 AM (GMT -7)   

Thanks for all the information. I had no idea it was a blood thinner. I don't know if I had problems with thick blood, so I don't know if I'll be able to notice that. But I have noticed some of my stomach problems have gotten better.

New Member

Date Joined Apr 2008
Total Posts : 12
   Posted 5/16/2010 6:28 PM (GMT -7)   
Hey Nicky D,
I am a firm believer in Lumbrokinase.  I had the Hemex test confirm my mild hypercoagulation and started my Doxy Rx for about 2 1/2 weeks and then had a herx from hell, lying in bed, shaking, feeling like a freight train hit me.  The "Buluoke" helped break into the biofilm and I have been taking a break from my Doxy/Mycobutin regimen then Azithro/Mepron for about four months.  I had elevated triglycerides, and I am as healthy eater as any and knew the Lyme had done it to me with the fibrin.  Within four months of taking the Lumbrokinase, I was back to normal. 
I continue to have severe bone/joint pain, back pain, the fatigue, but I am functioning.  Thank God!
Kay of KC
"Stuey06"  my pugs name
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