"Can someone please tell me why in god's name would IGM which means more recent be positive and IGG which shows up later be negative. I just don't get this to save my life."
Lyme is continuously changing its outer surface, therefore the body has to continually make new antibodies. This explains IgM antibodies in late-stage Lyme, especially if the positive bands keep changing. Seroconversion to IgG may be delayed or hindered because of immunosuppression caused by the Lyme bacteria (and/or coinfections). Also, the IgM and/or IgG antibodies may all be bound to Lyme proteins, thus undetectable to the tests.
Somebody remind me why ins. co's insist on a positive test when the CDC itself says Lyme is a clinical diagnosis and that test results should not be relied upon for diagnosis??
I hope this helps - take care,
Chronic Lyme Disease, Chronic Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, etc.; G-Tube; Currently weaning off TPN.
Meds: Pulmicort, IV Doxycycline, Heparin (to flush PICC line), Claritin, Singulair, Domperidone, Colloidal Silver (topically & nasally), probiotics, Liver support herbs, Ailanthus, digestive enzymes, homeopathy.