Hemopyrrollactamuria (HPU), also known as kyptopyrroluria (KPU), is a severe but reversible deficiency of zinc, biotin, manganese, vitamin B6 (or P5P), and arachidonic acid. When treated for this condition, Dr. Klinghardt"s patients were able to move forward in their treatment with success. Dr. Klinghardt has found that HPU occurs in Lyme disease around 80% of the time (or more), and it occurs in over 75% of patients with heavy metal poisoning. The incidence of HPU in children with autism is over 80%.
It can be tested by Vitamin Diagnostics.
See Dr. K's power point presentation:
Dr. Mercola's presentation:
Dr Klinghardt on KPU/HPU
Dr. Klinghardt talked about HPU. He noted that the same detoxification genetics are involved in Lyme disease, autism, MS, Parkinson's and other neurological diseases. It is a compromise in the detox pathways that sets the stage for illness. If you produce ten toxins and only remove one, you become ill. HPU is even deeper than the genetics.
Beyond zinc, manganese, B6/P5P, arachadonic acid (omega 6), several other nutrients may be depleted in those with HPU. Chromium is now believed to be one of these. If you are deficient in zinc and chromium resulting from HPU, insulin resistance often develops.
Defective heme leads to lower oxygen which promotes the proliferation of the infections. Zinc, copper, and iron are the most important minerals that support WBCs ability to fight infections.
HPU travels from the mother's side of the family. Dr. Klinghardt notes that the bugs can induce the HPU condition through the disabling of a single molecule and that this is an elegant representation of how advance these organisms are.
P5P is needed for the absorption of zinc, manganese, magnesium and chromium. Fish oil is often best for kids, but parent oils or seed oils are far better for adults.
Given that the body will pull zinc from the bones when zinc is low in the body, RBC zinc testing is not an accurate means of determining a zinc deficiency.
Dr. Klinghardt suggests that HPU leads to leaky gut syndrome. He also believes that IV Glutathione is rarely helpful for patients. A better option may be to look at the methylation cycle issues which may be the cause of low glutathione levels. Many components of the methylation cycle are heme dependent and heme is not properly synthesized in patients with HPU.
Lyme biotoxins are excreted by the liver. Taurine is a major factor in the excretion of biotoxins and is also found to be low in people with HPU. If there is not enough taurine available, one will be unable to remove biotoxins. It is a huge part of the equation.
HPU patients are often sulfur intolerant. They may require molybdenum to address the sulfur issue. Hydrochloric acid enzymes are zinc dependent. If you have a low level of zinc, you may not tolerate it well and will become nauseated upon ingestion until you have been on the protocol for a couple of months. One way to avoid this problem is to open the zinc capsules and put them in a small amount of vinegar.
Another possible source of zinc is oysters. Oysters have about 60mg of zinc picolinate. Thus one option for treating HPU may be 4-6 oysters plus B6.
300 of 1500 known metabolic enzymes are zinc dependent.
In terms of metal detoxification which is a key part of the treatment for HPU, MicroSilica is 100 times more effective than DMSA or DMPS. Detoxification of the gut sends the signal to other body compartments to release more metals. MicroSilica often helps with mental function, vision, and reduced ringing in the ears. MicroSilica should not be taken at the same time as zinc.