Lyme Western Blot and KPU

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Regular Member

Date Joined Jun 2007
Total Posts : 417
   Posted 6/14/2010 7:56 AM (GMT -7)   

IgM- **31, **39, **89-93  (all IND)

          **41 + + +

              66 +


IgG- **41 + +

        **31, 45, 58 (all +)


Hi folks, I'm writing for some feedback, as there is descrepency with my docs on what the above means (active lyme or not).  Technically, the IgG would only be Igenex positive.  My symptoms aren't traditional but my cd57 is 15.

My other question is for those of you whom have tested positive for KPU/HPL.  Any of you out there?  And if yes, do you treat the KPU first?

Thanks so much!


Veteran Member

Date Joined Apr 2009
Total Posts : 1304
   Posted 6/14/2010 7:44 PM (GMT -7)   
Tracy, I am sorry, but I do not know what KPU is?

However, your reactive and postive bands seem to imply LYme, as does your CD57 (ESPECIALLY!) . Some Drs believe that Lyme specific positive and reactive bands indicate that you have had a lyme infection at some point, but that it is no longer an active infection. Others believe that one lyme species specific band indicates you have an active lyme infection. This is probably where your Drs disagree.

There are just too many unknowns, esp w/ WB tests. That is the reason that your CD57, ALONG WITH your WB, do seem to indictate Lyme.

What do you mean that your symptoms are not traditional?

And also, please don't forget to tell us what KPU is.

Tracy, I wish the best for you -- that you NOT have lyme and that there are explanations for your lab results that are simpler than Lyme.
Bit 1972: Acute and chronic tonsillitis, UTI, miscarraige, appendicitis, hypoglycemia,  chronic neck pain w/ crushed vertibrae, chronic severe back pain, mitral valve prolapse, depression, resolution?
Bit Mother's Day 2007: Lyme, Babesia microti, hypothyroidism, EBV, HHV6, Parvovirus B19, low adrenals &misc other hormones, depression, anxiety, more of the above.

Regular Member

Date Joined Jun 2007
Total Posts : 417
   Posted 6/15/2010 4:36 PM (GMT -7)   
Hi!  I wonder why I didn't get an e-mail response that there was a response. ?!
Thanks for the feedback re: Western Blot.  I got both responses (from LLMDs!).
Hi, sorry for throwing out initials and not explaining! 
Hemopyrrollactamuria (HPU), also known as kyptopyrroluria (KPU), is a severe but reversible deficiency of zinc, biotin, manganese, vitamin B6 (or P5P), and arachidonic acid. When treated for this condition, Dr. Klinghardt"s patients were able to move forward in their treatment with success. Dr. Klinghardt has found that HPU occurs in Lyme disease around 80% of the time (or more), and it occurs in over 75% of patients with heavy metal poisoning. The incidence of HPU in children with autism is over 80%.
It can be tested by Vitamin Diagnostics.
See Dr. K's power point presentation:
Dr. Mercola's presentation:
Better Health Guy's article:

Dr Klinghardt on KPU/HPU

Dr. Klinghardt talked about HPU.  He noted that the same detoxification genetics are involved in Lyme disease, autism, MS, Parkinson's and other neurological diseases.  It is a compromise in the detox pathways that sets the stage for illness.  If you produce ten toxins and only remove one, you become ill.  HPU is even deeper than the genetics.

Beyond zinc, manganese, B6/P5P, arachadonic acid (omega 6), several other nutrients may be depleted in those with HPU. Chromium is now believed to be one of these.  If you are deficient in zinc and chromium resulting from HPU, insulin resistance often develops.

Defective heme leads to lower oxygen which promotes the proliferation of the infections.  Zinc, copper, and iron are the most important minerals that support WBCs ability to fight infections.

HPU travels from the mother's side of the family.  Dr. Klinghardt notes that the bugs can induce the HPU condition through the disabling of a single molecule and that this is an elegant representation of how advance these organisms are.

P5P is needed for the absorption of zinc, manganese, magnesium and chromium.  Fish oil is often best for kids, but parent oils or seed oils are far better for adults.

Given that the body will pull zinc from the bones when zinc is low in the body, RBC zinc testing is not an accurate means of determining a zinc deficiency.

Dr. Klinghardt suggests that HPU leads to leaky gut syndrome.  He also believes that IV Glutathione is rarely helpful for patients.  A better option may be to look at the methylation cycle issues which may be the cause of low glutathione levels.  Many components of the methylation cycle are heme dependent and heme is not properly synthesized in patients with HPU.

Lyme biotoxins are excreted by the liver.  Taurine is a major factor in the excretion of biotoxins and is also found to be low in people with HPU.  If there is not enough taurine available, one will be unable to remove biotoxins.  It is a huge part of the equation.

HPU patients are often sulfur intolerant.  They may require molybdenum to address the sulfur issue.  Hydrochloric acid enzymes are zinc dependent.  If you have a low level of zinc, you may not tolerate it well and will become nauseated upon ingestion until you have been on the protocol for a couple of months.  One way to avoid this problem is to open the zinc capsules and put them in a small amount of vinegar.

Another possible source of zinc is oysters.  Oysters have about 60mg of zinc picolinate.  Thus one option for treating HPU may be 4-6 oysters plus B6.

300 of 1500 known metabolic enzymes are zinc dependent.

In terms of metal detoxification which is a key part of the treatment for HPU, MicroSilica is 100 times more effective than DMSA or DMPS.  Detoxification of the gut sends the signal to other body compartments to release more metals.  MicroSilica often helps with mental function, vision, and reduced ringing in the ears.  MicroSilica should not be taken at the same time as zinc.

Veteran Member

Date Joined Apr 2009
Total Posts : 1304
   Posted 6/16/2010 8:17 PM (GMT -7)   
TAllison, Thank you for all this new information, but I, for one, am overwhelmed w/ all this new info!

Sheesh, when I realized and learned I had Lyme, all I'd hoped for was a 'cure' -- some abx or the promise that it would run its course.

duh..... NOT.....
Bit 1972: Acute and chronic tonsillitis, UTI, miscarraige, appendicitis, hypoglycemia,  chronic neck pain w/ crushed vertibrae, chronic severe back pain, mitral valve prolapse, depression, resolution?
Bit Mother's Day 2007: Lyme, Babesia microti, hypothyroidism, EBV, HHV6, Parvovirus B19, low adrenals &misc other hormones, depression, anxiety, more of the above.

New Member

Date Joined Jun 2010
Total Posts : 1
   Posted 6/18/2010 10:09 AM (GMT -7)   
I have KPU and have been going thru Dr. K's protocol for 8 weeks. It's been very difficult going thru the detox - anxiety and depression like I have never experienced. Thanks for posting that interesting article, I've never seen that one and it was very informative. Have you started the protocl yet? I've got adrenal issues, thyroid issues, liver stress, and CFS (As well as Lyme) but I think most of my issues are due to the KPU. I'd love to hear how you're doing thru the protocol/ Do you take iron as well?

Regular Member

Date Joined Jun 2007
Total Posts : 417
   Posted 6/25/2010 1:58 PM (GMT -7)   
Hi!  I just typed a response and somehow it deleted itself!  Yes, I too am overwhelmed with it all.  Yes, I do take iron-well, Ferritin from Cardiovascular Research.  I am not looking forward to detoxing, but if it will lead to sleeping without twitching and mouth partching, then I'll be sooooo happy.
Goldie, have you done the HPL test?  Mine was high at 560 I think but I have nothing to go on but the range (goes to 250).  I can't find anything out about the specifics of the level.  Maybe I will call back Vitamin Diagnostics.
Haven't started it yet, docs trying to figure out how to compound KPU treatment specifically for me.  They didn't want me on the Core or any of those products.  Want me to have Calcium EDTA supp on hand for the detox.  I've never done that, not looking forward to that either.
Goldie, what time are you taking the protocol?  I will have it in a liquid. 

Dan's Mother
Regular Member

Date Joined Feb 2007
Total Posts : 189
   Posted 6/25/2010 3:42 PM (GMT -7)   
Hi Tracy!

I'm just wondering if you could Email me the name of the doctor that is treating you for KPU. I've been toying with the idea of going out to Seattle to see Dr. K., but you really have to stay there for months on end. I'm hoping that you have someone a bit closer. Also how did you go about getting the testing done? Is Vitamin Diagnostics in Europe?

Glad to see that you are finally figuring out what has been going on with you! I know it's been a long haul.

Take Care,

Regular Member

Date Joined Jun 2007
Total Posts : 417
   Posted 7/10/2010 3:26 PM (GMT -7)   
Hi!  Karen, glad to connect with you.  Glad you are getting the kit finally!
Goldie, can you e-mail me personally?  Are you on facebook?  There are a few of us linked that are going through KPU treatment.
I am starting week 3 on my KPU treatment (compounded formula)... I just noticed it doesn't have b6 in it, only p5p.  ??
I am starting the EDTA treatment, and I'm wondering if anyone knows how far away I need to take my omegas and other stuff from the EDTA.  I had them compounded.  Online it says to take them at night, but nighttime is my worst time.  So I am going to try them during the day.
Anyone else out there doing some form of KPU treatment??????

Veteran Member

Date Joined Aug 2007
Total Posts : 4399
   Posted 7/10/2010 8:28 PM (GMT -7)   
P5P is a form of Vitamin B6.

Don't know anything about the other stuff, sorry... If I had to guess, I'd say giving it 2-3 hours between the EDTA and your other supplements should be enough time, but I don't know for sure because of the chelating effects of the EDTA. Maybe your pharmacist can tell you?

Oh, btw, I'm not on KPU treatment...don't know if I even have it (I don't think I do...)...
Chronic Lyme Disease, Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, etc.; G-Tube; TPN via PICC (trying again to wean off the TPN).
Meds:  IV Cipro, Heparin (to flush PICC line), Singulair, Claritin, Domperidone, Colloidal Silver, probiotics, digestive enzymes, Milk Thistle & other liver support herbs, Magnesium, homeopathy.

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