Positive test result from Igenex

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InfectedinFL
Regular Member


Date Joined May 2010
Total Posts : 59
   Posted 6/29/2010 4:39 PM (GMT -7)   
After all of the back and forth with Dr's, I have finally gotten the test results back from Igenex. I had test 188 and 189 done. Both came back + by Igenex standards. The IgM came back + by Igenex and CDC criteria. The IgM came back + by Igenex and - by CDC. I was hoping you guys can help me make some sense of the numbers. The DR. that I used is a friend and neighbor, but he is not Lyme Literate. Below is the bands that tested + on both. Thanks for all of your help.
 
p.s. My doc wrote me 31 days of Doxy to get started on again.  Took 10 days of Doxy 5 weeks ago.
 
IgM:
+ bands
23-25
31
41
58
83-93
IND band
34
 
IgG
+ bands
28
31
41
58
IND band
34

daisyrlb
Regular Member


Date Joined Jan 2010
Total Posts : 277
   Posted 6/29/2010 9:17 PM (GMT -7)   
Per Dr. C (MO) year 2000

FYI: "osp" = outer surface protein


On the outer surface of the Lyme bacteria are various proteins. As they have been discovered, they have been assigned letters, such as outer surface proteins A, B, and C.

The following is a brief explanation of the test results. Again, each band is an antigen complexed (bound together) with an antibody made by the immune system, specifically for that antigen (part) of Borrelia burgdorferi.

18: An outer surface protein.

22: Possibly a variant of outer surface protein C.

23-25: Outer surface protein C (osp C).

28: An outer surface protein.

30: Possibly a variant of outer surface protein A.

31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).

37: Unknown, but it is in the medical literature that it is a borrelia-associated antibody. Other labs consider it significant.

39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.

41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.

45: Heat shock protein. This helps the bacteria survive fever. The only bacteria in the world that does not have heat shock proteins is Treponema pallidum, the cause of syphilis.

58: Heat shock protein.

66: Heat shock protein. This is the second most common borrelia antibody.

73: Heat shock protein.

83: This is the DNA or genetic material of Borrelia burgdorferi. It is the same thing as the 93, based upon the medical literature. But laboratories vary in assigning significance to the 83 versus the 93.

93: The DNA or genetic material of Borrelia burgdorferi.

In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.

These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93.
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