Yes, Lyme can cause a high SED rate. Mine has been as high as 102 (normal is <20 for women, <15 for men). I also had a high ANA with duel pattern (homogenous, speckled), but no positive splits (i.e., RF, SSA, SSB, etc.) to specifically diagnose a connective tissue disorder...so what they diagnosed was Undifferentiated Connective Tissue Disorder, and later that was changed to "Secondary Lupus-Like Disorder" - when I asked what it was secondary to, they couldn't tell me. I was subsequently diagnosed with Lyme and upon researching this nasty disease, believe the Lyme is responsible for the high ANA and SED rate in my case.
Chronic Lyme Disease, Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, etc.; G-Tube; TPN via PICC (trying again to wean off the TPN).
Meds: IV Cipro, Heparin (to flush PICC line), Singulair, Claritin, Domperidone, Colloidal Silver, probiotics, digestive enzymes, Milk Thistle & other liver support herbs, Magnesium, homeopathy.