Eosinophilic Cationic Protein

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Date Joined Oct 2007
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   Posted 7/13/2010 8:03 AM (GMT -7)   

Post Edited (georgiagirl) : 3/5/2011 3:04:29 PM (GMT-7)

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Date Joined Aug 2007
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   Posted 7/13/2010 9:07 AM (GMT -7)   
ECP is a protein released when eosinophils degranulate (explode). This happens during allergic reactions or during some immune responses to parasites. Since Babesia is a parasite, it is reasonable to assume the body sends eosinophils to attack the Babesia. And I know there is at least one case report about a person with Hyper-Eosinophilic Syndrome who was also diagnosed with Babesiosis. So it is possible that ECP levels can be used to give a rough indication of disease activity (more accurately, immune activity against the parasite).

Testing ECP levels in the 3 specific situations may show different levels of ECP in a certain pattern if one has Babesia...I am guessing here, though and don't really know for sure.
Chronic Lyme Disease, Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, etc.; G-Tube; TPN via PICC (trying again to wean off the TPN).
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Date Joined Oct 2007
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   Posted 7/13/2010 11:38 AM (GMT -7)   
Thank you Razzle.

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Date Joined Jul 2010
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   Posted 7/15/2010 1:43 PM (GMT -7)   
FYI there is a "letter to editor" to a medical journal describing a case report about HES/Babesia, BUT as of today no real case report has been published or accepted into a journal.Some "Dr" claiming he has a patient and did a case report is not the same IMO as there actually being one. If by now it has been published Id be very interested in seeing the citation.

AND by definition , IF that patient exists with the so called HES and Babesia, it means they either did NOT have "HES" at all or had BOTH HES and Babesia; with that HES diagnosed BEFORE contracting Babesia- since the absolute criteria for HES is not having a cause for the high eos count.

True "HES" means "no cause for the high eos levels + tissue infiltration"
Once you have a cause, its merely "eosinophilia due to cause"
so , if Babesia caused that person's eos misery it is " Babesia induced eosinophilia", NOT "HES"

and yes, it matters. As a pathology nurse supervisor its very important to me, to not be mistaken with details.

The problem with using the ECP is that while in only a few Babesia cases will the eos be high, affecting the ECP result; the eos may also be high due to other reasons as well. OR the eos can be normal and still have Babesia. The ECP doesnt "prove" Babesia at all. it simply "proves" high eos and therefore high amounts of broken eos, from any cause.

whats important to know is that the "Dr" associated with that "case study" has many peers questioning him, and his "results", AND that ECP cannot monitor, evaluate, nor prove existence of Babesia infections.

So far the best tests for Babesia diagnosis are PCR's and FISH ( which are special smears that look at and in the RBC where Babesia take up residence.)Plus the clinicals of exam, history and symptoms.

Once Babesia is in fact diagnosed or strongly suspected, ECP may be important in managing symptoms,only IF the eos become elevated; since the higher than normal eos can cause additional or worsening of existing symptoms. BUT only if and when the patient has abnormally high eos on CBC.

Treatments for real "HES" are risky and are warranted only in serious circumstances and shouldnt be used for mildly elevated eos and/or with no tissue/organ involvement.

Do not take this as medical advice and always discuss with your Dr all tests and treatments suggested by them or anyone.

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Date Joined Jun 2007
Total Posts : 417
   Posted 7/15/2010 5:50 PM (GMT -7)   
Hi!  Wow, that was a bit advanced for me, reading this thread.  I wanted to write here because I have been diagnosed with Eosinophilic Enteritis, and have lyme (exposed to bart too).  Not sure if we're talking about the same thing, as I don't think I have Babesia, and haven't had this test.  However, I've had a bunch of biopsies (tonsils, esophogas, colon, uterine etc), and they found EE.  The NIH found it when the doctors didn't (of course they didn't find Lyme or co-infection).  Some docs say it is an allergy/immune response.  One doc says high dose L-glutamine will address it... but I've been wondering about it.
When I look up KPU/HPL (which reportedly many chronic lyme patients have), EE is listed as co-occuring.  I tested highly positive for HPL. 
Ok, not sure if I've added anything to the discussion.  Quite possibly derailed it... sorry.
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