Positive anti-SM antibodies anyone?

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Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4399
   Posted 7/28/2010 5:00 PM (GMT -7)   
Has anyone here with Lyme had an ANA test done that came back positive with elevated anti-SM antibodies too?
 
The lab made an error on my last blood test and ran the ANA screen (have had positive ANA titers up to 1:360 w/ speckled & homogenous pattern before...but not with any of the specific antibodies until now), and it surprisingly came back positive, with positive anti-Sm antibodies as well.  This time, they didn't give a titer for the ANA, nor did they specify the pattern.
 
I don't have "classic" Lupus symptoms, and never got much help from Plaquenil (I get better joint pain relief from homeopathy, Nettles, & heat, and none of these bother my eyes like the Plaquenil did).
 
But I have been in a symptom flare-up the last couple weeks and thought it was a herx., but maybe not...I don't know.
 
Thanks,
-Razzle
Chronic Lyme Disease, Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, etc.; G-Tube; TPN via PICC (trying again to wean off the TPN).
Meds:  IV Cipro, Heparin (to flush PICC line), Singulair, Claritin, Domperidone, Colloidal Silver, probiotics, digestive enzymes, Milk Thistle & other liver support herbs, Magnesium, homeopathy.


spaztick
Veteran Member


Date Joined Oct 2006
Total Posts : 851
   Posted 7/28/2010 6:20 PM (GMT -7)   
Hi Razzle,

I have never had a positive ANA, but I did get a positive smooth muscle antibody test a few years ago. Nothing ever came of it diagnostically, because all other blood work was good.

Prior to being dx'd w/ Lyme/babs, my previous GP thought I may have Lupus. My Lupus panel (blood work) was OK in '07, so he said to check it in one year. Thank God I stumbled upon a locum in his office later that year who sent me to the only LLMD in BC, Canada - who dx'd Lyme/babs.

I've been on Plaquenil as a cyst-buster since '08 and I do believe it is helpful for my spinal osteoarthritis. You poor thing, what with all you have on your plate health-wise, I certainly wouldn't want to hear that you have Lupus, too! I hope you feel better soon.

DocGP
Regular Member


Date Joined Feb 2010
Total Posts : 184
   Posted 7/28/2010 9:25 PM (GMT -7)   
all negative for me...so far.

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4399
   Posted 7/29/2010 3:22 AM (GMT -7)   
Just to clarify, anti-Sm antibodies are part of the ANA panel and the "Sm" is "Smith" and not "smooth muscle."

Spaztik, thanks for your post.

Lupus has been tossed around as a possible diagnosis for me by various MD's I've seen over the last 5 years...that's how I got the "Secondary Lupus-Like Syndrome" (some of the doctors called it Undifferentiated Connective Tissue Disorder) - because at one point, I had a SED rate of 102, a positive ANA with speckled/homogenous pattern, a rash on my face that resembled the Malar rash classic to Lupus, and the "arthritic" hands (but no redness/swelling of joints, just stiffness & pain). So they put me on Plaquenil and after about 3-4 months, it did help reduce the severity of the hand pain, but did nothing else for any of my other symptoms (this was in 2005-2006, before I was diagnosed with Lyme).

I later discovered that the rash was actually an allergic reaction to the soap I was washing my eye-glasses with - haven't had the rash since switching to a different soap. The hand pain seems to improve with abx, and the ANA had come down to "normal" by the time I was dx. with Lyme...and I never expected to see it elevated again. So I guess that's why this test result has me scratching my head and questioning what connection, if any, there could be between the anti-Smith antibodies and Lyme.

Thanks,
-Razzle
Chronic Lyme Disease, Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, etc.; G-Tube; TPN via PICC (trying again to wean off the TPN).
Meds:  IV Cipro, Heparin (to flush PICC line), Singulair, Claritin, Domperidone, Colloidal Silver, probiotics, digestive enzymes, Milk Thistle & other liver support herbs, Magnesium, homeopathy.


yarniac
New Member


Date Joined Jul 2010
Total Posts : 11
   Posted 7/29/2010 4:36 AM (GMT -7)   
Hi Razzle. I have a positive ANA 1:180 with speckled pattern, high se rate and high c reactive protein, and also a positive anti-sm. and it was the anti smith not anti smooth muscle. This test is very rarely false positive and very specific for lupus. but my rheumy said he saw no evidence for any lupus with me. my mother and grandmother have lupus and this could explain why I tested positive??. That rheumy is fibromyalgia happy. now I believe that fibro is real and horrible, but it didn't completely explain my symptoms and I kept wanting to find out what was wrong and get treated, but he was just happy with saying - just fibro. I quote him - "you are just a control person and don't like not being able to control how you feel. buy a book and accept it" rrgh


eyes

I also tried plaquenil and it did nothing for me as well. but prednisone made me feel like I was 20 years old again. now I am worried if I do indeed have lyme, how much damage 18 months of 20 - 60 mg of prednisone a day did.

it is possible to have both lyme and lupus I suppose. this would complicate dx and treatment (like it isn't complicated enough right?) maybe a lyme literate rheumy? I know there is one with liads board. he is listed on the treatment guidelines as a member of that committee.
dx: Fibromyalgia, Epilepsy, Narcolepsy, Cataplexy. some unknown Neuro-Muscular disorder and possible lyme.
Prescription Meds: Darvocet, Lamictal, Zoloft, Trazadine, doxycycline, fluconizole, lodine.
Supplements: D3, magnesium, calcium, glucosamine, B12.

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