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Explanation of bands

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Lyme Disease
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CajunGrl
Veteran Member
Joined : Mar 2009
Posts : 4717
Posted 12/27/2010 2:56 PM (GMT -8)
Some of you may not have read the "New To Lyme?.....Start Here!" post, so I am posting a few things that may help explain some things that you may not understand.

Western Blot Bands description:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

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Traveler
Elite Member
Joined : May 2007
Posts : 36542
Posted 12/30/2010 8:09 PM (GMT -8)
Ahhh!! this one too! - bumpity bump-bump!! smilewinkgrin smilewinkgrin
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Razzle
Veteran Member
Joined : Aug 2007
Posts : 4415
Posted 12/31/2010 3:30 PM (GMT -8)
I wish someone would post the UPDATED version of this... Band 18, according to Dr. Jones, is specific for Bb and in fact if one has only band 18, then he considers them positive for Lyme...
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CajunGrl
Veteran Member
Joined : Mar 2009
Posts : 4717
Posted 12/31/2010 4:45 PM (GMT -8)
Razzle,

I'm not sure that all doctors look at band 18 as being specific for Lyme. Well, at least the doctors I saw didn't take it into consideration a year ago. Things may have changed since then though. Can you post the article if you don't mind so I can read it? Thanks hun.
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Traveler
Elite Member
Joined : May 2007
Posts : 36542
Posted 1/10/2011 11:06 AM (GMT -8)
bump!
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nasalady
Veteran Member
Joined : Sep 2009
Posts : 1176
Posted 1/10/2011 7:26 PM (GMT -8)
The importance and specificity of some of the bands is still a bit controversial, I think.
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Traveler
Elite Member
Joined : May 2007
Posts : 36542
Posted 1/11/2011 12:14 PM (GMT -8)

nasalady said...
The importance and specificity of some of the bands is still a bit controversial, I think.

Personally I believe it will be that way until enough research $$ are finally invested to not only know, but to positively identify each and every strain of each and every type of tbi.
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CajunGrl
Veteran Member
Joined : Mar 2009
Posts : 4717
Posted 1/11/2011 2:50 PM (GMT -8)
I agree Traveler. I had a ++ on band 18 and it was never mentioned. I really wish that more research was done and that they would make a more reliable test so we wouldn't have to decipher through each band.
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