Oh, springsjean sorry to hear your husband isn't well.
After I had been treated for Lyme for a while, my husband started exhibiting some of the symptoms of lyme: Swollen, painful knees; irritability; brain fog, neck and back pain and crunchiness and unexplained chills and sweats among them. He was tested for Lyme by Quest and it came up negative, no bands. With Igenex it came up positive.
His lyme -- and he is not always willing to admit he has it although he fully understands that the Borrelia spirochete behaves like syphilis -- did not behave like mine. He had no herx even though our llmd tried three different kinds of antibiotics. Instead, I have put him on a series of herbal remedies that have been helping me. His irritability is gone (except, of course, when I am actually being irritating!), his knees only hurt him as much as a 64 year old who has been very active should, his brain fog has lifted, and his neck and back are much better.
Hope you get some answers soon!