Yasko's Simplified Methylation Protocol

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yazzer
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Date Joined Jun 2011
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   Posted 12/1/2011 11:02 AM (GMT -6)   
Hi all:
 
Since you asked, I thought I'd post on this. Back in early October, my LLMD sent me a link to a method for correcting the methylation cycle in our bodies. The study was done for people with CFS but applies to most all chronic diseases. The 1st Lyme Disease Assoc meeting I went to in my local area way back in June mentioned disruption of the methylation cycle as something that wreaks havoc to our natural bodily homeostasis and depletes glutathione critical in our ability to detox. I didn't think much of it then but when my doc sent the link, I decided that this might be a key to rebalance my adrenals and other systems so I tried it. It's inexpensive and relies primarily on precursors to folate and B12 in our systems. Basically, I take the following daily:
 
1. One-quarter tablet (200 micrograms) Folapro (Folapro is 5-methyl tetrahydrofolate, an active form of folate, sold by Metagenics).

2. One-quarter tablet Intrinsic B12/folate (This includes 200 micrograms of folate as a combination of folic acid, 5-methyl tetrahydrofolate, and 5-formyl tetrahydrofolate, also known as folinic acid or leucovorin (another active form of folate), 125 micrograms of vitamin B12 as cyanocobalamin, 22.5 milligrams of calcium, 17.25 milligrams of phosphorus, and 5 milligrams of intrinsic factor, also Metagenics).

3. Up to two tablets (It's best to start with one-quarter tablet and work up as tolerated) Complete Vitamin and Ultra-Antioxidant Neurological Health Formula from Holistic Health Consultants (This is a multivitamin, multimineral supplement with some additional ingredients. It does not contain iron or copper, and it has a high ratio of magnesium to calcium. It contains antioxidants, some trimethylglycine, some nucleotides, and several supplements to support the sulfur metabolism.) (for me, I just use my regular Solgar V-2000 multi-vitamin)

4. One softgel capsule Phosphatidyl Serine Complex (This includes the phospholipids and some fatty acids) (Get at any Vitamin Shoppe type of store)

5. One sublingual lozenge Perque B12 (2,000 micrograms hydroxocobalamin with some mannitol, sucanat, magnesium and cherry extract) Google this - I think Perque is the manufacturer.

The very first night, I slept MUCH better than I had in months and this trend has continued. I don't know if it's so much the methylation cycle re-establishing itself or what. My doc thinks it might simply be due to the high doses of bioavailable B12 involved. Folks with low levels of B12 - like many with Lyme - have trouble sleeping. B12 supplementation may help. Whatever it was, it has helped me. Maybe it's the methylation or maybe it's just the B12 helping me sleep and the better sleep has helped me get better. Dunno. This is just my experience as I experiment with different thigns from time-to-time.

Here's a link explain the protocol:  http://www.ei-resource.org/articles/chronic-fatigue-syndrome-articles/simple-methylation-treatment-protocol-for-chronic-fatigue-syndrome/ Below, I also give an excerpt of the original e-mail poiting to the video my LLMD gave me back in Oct

Yazzer

Here's the  other:

You can find the video at this url:

http://iaomt.media.fnf.nu/2/skovde_2011_me_kroniskt_trotthetssyndrom/$%7Bweburl%7D

It is quite a long video, in three parts. They gave me several hours, so that I was able to go into considerable detail. I presented a basic
description of ME/CFS and then discussed the Glutathione Depletion--Methylation Cycle Block hypothesis, how it explains various aspects of ME/CFS, testing, treatment, and the clinical study performed by xxxxxx and xxxxxxx.

I hope you will find it interesting.

 

 

 


Razzle
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Date Joined Aug 2007
Total Posts : 4415
   Posted 12/1/2011 6:47 PM (GMT -6)   
Do not do this if you have sulfite intolerance or a CBS genomic variant. Other things must be done first, or this protocol will make you even sicker...I learned this the hard way.

To tolerate B-vitamins (other than B12), I have to do all of the following:

1. Eat a low sulfur, low protein diet.

2. Avoid all sources of sulfites as much as possible - this is difficult, because sulfites are literally everywhere - in the air (car exhaust), water, many foods, many herbs, many medications & supplements (mineral citrates, citric acid, ascorbic acid, sorbates, glycerine, etc.), etc.

3. Take Vitamin B12 injections. I do best with methylcobolamin...cyano- & hydroxo-B12 don't help, or else I get side-effects (jittery, shaky, insomnia). Oral/sublingual B12 does not work for me - I don't absorb it.

4. Molybdenum 1000mcg once a week (I started with this amount daily for a few weeks to restore levels)...this mineral is depleted extra fast when one has the CBS variant.

5. Yucca Root daily...to help with excess ammonia produced as a result of the CBS variant.

6. Nettle powder daily...I don't know why, but it helps.

7. GABA at night...helps me a lot with anxiety and sleep quality, and is recommended by Dr. Yasko. Apparently, calming neurotransmitters are depleted in those with methylation cycle blocks, and GABA can help compensate for this.

8. Magnesium...needed by the enzymes in the methylation cycle. Without magnesium, these enzymes cannot function. Iron and Zinc are also needed, but should not be overdosed...

A recent discovery for me: For energy, I find supplementing with L-Lysine helpful...apparently, Lysine is needed by the cell's mitochondria. Mitochondria are where the energy is produced for all cells in the body...without adequate materials, the mitochondria can't do their job, and we get tired... I believe Lyme depletes us so much that the mitochondria are affected, so supporting the mitochondria is very important.

I don't know if I'll ever be able to take large doses of B-vitamins, but at least with the above supplements, now I can somewhat tolerate RDA amounts of B vitamins without them sending me into a tailspin of reactions, insomnia and shaking/jitters.

More info on methylation:
http://www.heartfixer.com/AMRI-Nutrigenomics.htm

This is complicated stuff, so don't feel bad if you find it all difficult to follow. I've been trying to wrap my brain around this stuff sine 2003 (when I was first diagnosed with sulfite sensitivity, and later found that this is secondary to numerous nutrigenomic variants, especially the CBS gene variant), and still feel like I've only just barely grasped the basics.
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Singulair, Andrographis & other herbs, homeopathy, supplements, etc.

yazzer
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Date Joined Jun 2011
Total Posts : 898
   Posted 12/2/2011 4:43 PM (GMT -6)   
Razzle : how would one know if they had the sulfite or CBS issue? Is there a test for it? I must not have it because the tasking method has worked great for me since I started it on October 18th! Thx for your response!

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4415
   Posted 12/2/2011 4:51 PM (GMT -6)   
Yes, there is a test for methylation cycle genomic variants. The least expensive test I know of is from Dr. Yasko's lab (I have no financial connections with Dr. Yasko or anything sold on the holisticheal.com website):

http://www.holisticheal.com/health-tests/nutrigenomic-testing/comprehensive-methylation-panel-with-methylation-pathway-analysis.html

The test is really the only way to know for sure which variants one has. The only reason I got interested in this stuff to begin with is because my Allergist diagnosed me with sulfite sensitivity. To try to understand what sulfite sensitivity really was all about, my researching lead me to the methylation cycle stuff, because the methylation cycle is where sulfites are processed by the body.

Take care,
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Singulair, Andrographis & other herbs, homeopathy, supplements, etc.

GWB
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Date Joined Jul 2005
Total Posts : 570
   Posted 12/4/2011 10:55 AM (GMT -6)   
Razzle, Dr. Cowden suggested I take Yucca Root for ammonia. I've been looking into it. Any potential side effects one needs to be concerned about when taking this? Is it really effective for removing ammonia from brain, liver and other organs?

Thanks!
Gary

oldschool
Regular Member


Date Joined Feb 2011
Total Posts : 42
   Posted 12/4/2011 1:29 PM (GMT -6)   
I've been reading a blog by a neurosurgeon, Dr. Jack Kruse, and when I saw methylation here I had to post some of his findings. He has some interesting and successful methods to get a human body up to optimum. I'm planning to make some changes along those lines because I want to build up my body as much as I can so IT can fight the bugs.

Check it out: jackkruse.com/

READERS SUMMARY:
1. What determines our ultimate health fate?
2. What exactly is epigenetics?
3. How does an autoimmune disease begin?
4. Is multiple sclerosis tied to gut inflammation?
5. What is an inflammasome and why is hypomethylation so critical?

My first post on epigenetics seems to have stimulated a lot of talk based upon the emails I received. I think we need to dig a bit deeper into this area because it is now clear scientifically that epigenetics really determines our ultimate health outcomes. In fact, it is the easiest way to alter our genomes by modifying our dietary choices. To begin let’s simply define what epigenetics is in 2011. Epigenetics is any mechanism that affects genes without chaining the nucleotide sequence of the DNA. The two major ways epigenetic modification occurs via our diet is via methylation of our DNA or of acetylation of our histone proteins. The amount of methyl and acetyl groups come from our diets. For example, when we have low methylation in our diet, our DNA becomes hypomethylated. Lower levels of methylation correlates with development of higher rates of cancer and with autoimmune conditions. Obviously, none of us wants to get cancer or autoimmune disease so I think we all need to pay attention about how epigenetics can help keep us free of disease.

Post Edited By Moderator (Traveler) : 12/4/2011 2:26:53 PM (GMT-7)


Traveler
Forum Moderator


Date Joined May 2007
Total Posts : 36310
   Posted 12/4/2011 3:27 PM (GMT -6)   
Hi Oldschool!
I just wanted to let you know all I did was make your link a hyperlink to make it easier for those interested in this to get to the material!
Co-Moderator, Lyme Disease ;)

Treating with Acupuncture, Traditional & Modern Chinese Medicine & Western Herbs. Before tx, I had all but 20 of the symptoms on the "Master Symptom List"

"Absence of proof is not proof of absence" - Dr. Edwin Masters, great LLMD & researcher -RIP

I break up my post because my eyes have been effected by TBI's as well, making long paragraphs very hard to read.

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4415
   Posted 12/6/2011 4:52 PM (GMT -6)   
GWB,

Just emailed you some info on Yucca.

Take care,
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Singulair, Andrographis & other herbs, homeopathy, supplements, etc.

Londolozi
Regular Member


Date Joined Mar 2014
Total Posts : 76
   Posted 3/6/2018 9:32 AM (GMT -6)   
So this is a new question to an old post, but I am suffering from terrible insomnia. I am not really sure if it is from the MTHFR, the Lyme, heavy metals or what, but I am reeling from exhaustion and in tears, unable to function. I saw that the phosphatidyl serine complex plus the other Yasko simplified protocol has helped Yazzer but when I look at the side effects of phosphatidyl, insomnia is one of them. I am reluctant to get yet another supplement to add to my already blossoming array, but happy to try anything to see if I can sleep. I really feel that if you have something going on, nothing will help until that something is corrected. I have tried nano hemp oil ( only made be more awake), melatonin, lemon balm. I haven't tried Motherwort yet, but have it as it is contraindicated with hypothyroidism, which I also have.
Happy to try any suggestions.

Many thanks

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32559
   Posted 3/6/2018 12:04 PM (GMT -6)   
How much melatonin did you try? I've read that most people don't take enough...


It might be worth a try to increase it, while you continue to search for something.

How are your adrenals? Have you had a 4 point saliva cortisol test done?

Can you sleep during the day at least?

Also, you mentioned hypothyroidism...what are your test numbers? Is it possible you don't have the right dosage of your meds?
My husband has issues with sleep - that are exasperated when he's not on enough synthroid.
(Opposite of what you'd think would happen)
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Londolozi
Regular Member


Date Joined Mar 2014
Total Posts : 76
   Posted 3/6/2018 12:27 PM (GMT -6)   
I have used as much as 5 of melatonin. If I use any more, it gives me a headache. I can sometimes sleep in the day. The infuriating part of all of this is I never can duplicate whatever has previously worked. The next time I try to do the same thing again, it doesn't work. I have had a lot of testing on metals, Lyme, MTHFR, parasites but not adrenals recently. There is only so much to work with and I am at a loss as to how to pull it all together.
I appreciate your getting back to me. I just contacted Dr. Rawls office and spoke to someone there and ordered a couple of supplements from them. I have been on the Cowden protocol, but have not really gotten what I need from that in the long run so may try the Vital Plan. Just waiting to hear back from Igenix about the latest Lyme testing. My CD-57 is consistently low, 18 and I also have EBV. Guess we are dealing with a lot.

The Dude Abides
Veteran Member


Date Joined May 2017
Total Posts : 1107
   Posted 3/6/2018 3:42 PM (GMT -6)   
Londolozi,

While my sleep is far from perfect, the two things that have helped me the most have been:

1. Low-Dose Naltrexone (2-3 mg at bedtime)
2. A supplement called "Deep Sleep" (bit.ly/2gFnLvv)

Lately, though, the "Deep Sleep" supplement may not be helping me as much. I've been taking it for at least a year, and perhaps two. So, I've been experimenting with Melatonin. I'm pretty sensitive to many compounds, so I started with a "small" does of 1 mg of Melatonin at bedtime. The next morning, after a miserable night of sleep, I felt as if I'd been hit by a bus.

This led me to do more reading on Melatonin. I discovered that the optimal dose of Melatonin is pretty small -- around 0.3 milligrams. That's 300 micrograms. That's according to Richard Wurtman, M.D. at the MIT Department of Brain and Cognitive Sciences. wurtmanlab.mit.edu/projects

<--- Begin Quote --->
Dr. Richard J. Wurtman, a distinguished professor of neuropharmacology at the Massachusetts Institute of Technology, said older people often have trouble getting to sleep because the pineal gland, where melatonin is produced, "gets calcified with age." Taking a little bit of the hormone makes up for the pineal gland's weakness, he explained.

In 2001, Wurtman and his colleagues published a study in the Journal of Clinical Endocrinology and Metabolism that suggested that small doses of melatonin -- no more than 0.3 milligrams -- could help older people conquer insomnia.

But it's got to be just this little bit, Wurtman said, because too much melatonin overwhelms and deactivates receptors that transfer the hormone into cells.

Wurtman noted that the Alberta study used doses as high a 6 milligrams. "They are giving 20 times the correct dose," he said. "The higher the dose we gave, the lower the response we got."

Most of the melatonin products now on the market give similar overdoses, Wurtman said. The result: "Your insomnia gets worse after a while," he said. "What you need is low doses that raise blood levels to where they were when they were young. It's the equivalent of hormone replacement therapy for women."

<--- End Quote --->

Dr. Wurtman developed a time-released, low-dose melatonin supplement called "Sleep Answer."

Dr. Richard Wurtman's "Sleep Answer" Low-Dose Melatonin, 28 Dual-Release Capsules
/www.amzn.com/B01ETU38FU
/www.healthydirections.com/sleep-answer (ingredient listed here)

It's a very clever design -- a capsule in a capsule. The first stage releases quickly, assisting with getting into sleep quicker. Then, several hours later, the second stage releases, helping the person stay asleep.

After looking at the ingredient list, however, I found the product uses a chemical dye: "FD&C Blue Lake #2." While the amount is almost certainly negligible, I decided to look for another option.

After another day of searching, I found a low-dose, extended release Melatonin supplement from Life Extension.

Life Extension 6-Hour, Time-Released Melatonin, 300 mcg
/www.amzn.com/B00CDABRUW

It's 0.3 milligram (300 microgram) and releases over six hours. I ordered it only a few days ago, so it's not yet arrived. I'm hopeful that it will help. We all know the critical importance of sleep.

Also, I ran across the following Medical Doctor in Texas that does a lot of investigation and work with patients who have sleep issues. She discusses the impact of Vitamin D, the B-Vitamins, and the Microbiome. I found the YouTube lecture to be quite interesting.

Dr. Stasha Gominak
How To Fix Your Sleep: /youtu.be/uj8FTWCb010
Personal Website: /drgominak.com

Obviously, sleep is an extraordinarily complex process, to say the least. There are many types of sleep disturbances. Some fall asleep fast, but can't stay asleep (like me), others have trouble getting to sleep, but, once asleep, they stay under. Others have some combination of the two.

There's also Obstructive Sleep Apnea, Central Sleep Apnea, Restless Legs Syndrome (RLS), Periodic Limb Movement Disorder (PLMD), etc. Of course, some of those are just labels of symptoms. (After two sleep studies, I was labeled with some of those.) But, as you wisely stated: "I really feel that if you have something going on, nothing will help until that something is corrected." I couldn't agree more. But, of course, using something in the interim, to help you sleep, is warranted.

Good luck with the Vital Plan Supplements. I'm guessing you may be trying their "HPA Balance" and "Pure Calm" products. I have the former, but not the latter. In fact, mine is still unopened. If the time-released Melatonin doesn't work for me, I'll try the "HPA Balance" product next.

I wish you the best of luck and hope you find something helpful soon. If you have the opportunity, please give us an update on anything that you found helpful.

Best Regards,
The Dude

Post Edited (The Dude Abides) : 3/6/2018 2:45:13 PM (GMT-7)


Londolozi
Regular Member


Date Joined Mar 2014
Total Posts : 76
   Posted 3/6/2018 3:50 PM (GMT -6)   
Wow, dude. Many thanks. Unfortunately, due to lack of sleep, I am having a hard time concentrating on all of your email, but I was able to scan most of it. I am actually unable to take the Calm due to the addition of the Motherwart, which is contraindicated for someone who has hypothyroidism. I keep a food/supplement/symptom diary and have for years and looked back to when this new bout of heavy insomnia started and it seems to possibly be connected to the nitric oxide dump exercises that I started doing. You can see more about this on line. It is supposed to be good for you but perhaps it isn't for me. So although I already did it twice today, tomorrow, I will try not doing it. I am also going for an infrared sauna tomorrow and have my fingers crossed that that will help.

BTW, I have noticed when I do dry brushing, it makes me have night sweats. Anyone else notice that?

Again, Dude, your kindness and effort to help is so appreciated. I will certainly let all know if I find the key to the sleeping issue.

The Dude Abides
Veteran Member


Date Joined May 2017
Total Posts : 1107
   Posted 3/6/2018 4:10 PM (GMT -6)   
Happy to try and help, Londolozi. I apologize for my eye-straining reply. shocked I tend to go overboard, at times. smile Wishing you deep, restorative sleep and the ability to wake refreshed!

Georgia Hunter
Veteran Member


Date Joined May 2012
Total Posts : 2116
   Posted 3/8/2018 3:48 AM (GMT -6)   
Thanks Dude!

The Dude Abides
Veteran Member


Date Joined May 2017
Total Posts : 1107
   Posted 3/8/2018 3:22 PM (GMT -6)   
Georgia Hunter said...
Thanks Dude!


My pleasure, my good man!

Last night, I actually slept for about five hours, before waking. For me, this was a welcome accomplishment. If I recall correctly, that's about how much sleep you tend to get, before you waken.

As I'd only slept 2 hours and 40 minutes the night prior, it may have been the exhaustion that helped me. But, I also did something new - I listened to a track from a sleep hypnosis program I found online.

Sleep HypnoPill
/sleephypnopill.com

This is the track listing:

1. Induction
2. Fight Insomnia
3. Fall Asleep Fast
4. Have Sweet Dreams
5. Wake up Energized
6. Sleep Calmly

It was Track #2 ("Fight Insomnia") to which I listened, via my iPod/earbuds, as I drifted-off. Whether or not it truly helped, I can't be sure. But, because I'm quasi-superstitious, I'm going to listen to it again tonight! smile

If you (or, anyone else) would like to give it a try, I've uploaded the tracks to Dropbox.

bit.ly/2FspsHS

Restful wishes,
The Dude

Londolozi
Regular Member


Date Joined Mar 2014
Total Posts : 76
   Posted 3/8/2018 4:07 PM (GMT -6)   
So Dude, you must have been sending me sleep vibes last night as I slept as well. Not non stop, but way more than I am used to. I also stopped the Armour thyroid meds and went back to the Snythroid, which I think may have really been what has been giving me the uptick in my insomnia. I never slept well, but since I started on the Armour, it has been substantially worse. I also had my first infrared sauna yesterday, but didn't sweat a drop. So who knows what did the trick for me last night, but I was grateful to have the sleep, regardless of what the reason was.
Tomorrow, I start with the Vital Plan and see how that goes.

So if I sleep tonight, I am on to something. I fear that I have felt that I have nailed things before, only to find that it is not the answer. Oh well; onward and upward.

Georgia Hunter
Veteran Member


Date Joined May 2012
Total Posts : 2116
   Posted 3/9/2018 1:13 AM (GMT -6)   
The Dude Abides said...
Georgia Hunter said...
Thanks Dude!


My pleasure, my good man!

Last night, I actually slept for about five hours, before waking. For me, this was a welcome accomplishment. If I recall correctly, that's about how much sleep you tend to get, before you waken.

As I'd only slept 2 hours and 40 minutes the night prior, it may have been the exhaustion that helped me. But, I also did something new - I listened to a track from a sleep hypnosis program I found online.

Sleep HypnoPill
/sleephypnopill.com

This is the track listing:

1. Induction
2. Fight Insomnia
3. Fall Asleep Fast
4. Have Sweet Dreams
5. Wake up Energized
6. Sleep Calmly

It was Track #2 ("Fight Insomnia") to which I listened, via my iPod/earbuds, as I drifted-off. Whether or not it truly helped, I can't be sure. But, because I'm quasi-superstitious, I'm going to listen to it again tonight! smile

If you (or, anyone else) would like to give it a try, I've uploaded the tracks to Dropbox.

bit.ly/2FspsHS

Restful wishes,
The Dude

I can get an extra hour by doing several things but they eventually wear off. Lithium orotate 10mg almost always helps.
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