I also had never taken ANY medications in my life prior to Lyme. However, I started to have seizures, paralysis of my limbs and organ involvement so I decided to do my strongest possible option which is oral antibiotics since I can't afford IV's. By that point, I had already been severely ill for many months and moderately ill for years. I wanted to stick with herbs, but looking back I would not have done herbs for an early case. I would want to make sure it was gone if it had not yet become chronic. Early cases are much easier to treat than late cases. I think it's better to hit it hard right in the beginning before it has a chance to progress. That way one can avoid having to stay on antibiotics for chronic Lyme long-term down the road.
A LLMD in my area recommends for a new case, 6 weeks of doxy, zithromax and flagyl. That way all 3 forms of Lyme are addressed. This doesn't treat co-infections (except for Erlichia).
I have heard that many people use Banderol/Samento for Lyme with great success. A LLMD has said that these two herbs can treat the spirochete, L-form and cystic form. There are also good herbal options for some of the co-infections (especially babesia). The Byron White formulas make things easy to dose if you can afford them. I haven't heard of a ton of people having success with bartonella through herbal protocols but perhaps once Lyme and babesia loads are lowered the immune system can take over for bart.