Rifampin make anyone else tired?

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wilson111797
Regular Member


Date Joined Feb 2014
Total Posts : 39
   Posted 4/1/2014 8:56 PM (GMT -6)   
For the record, I've never really gotten fatigue from Lyme...bartonella has been my biggest problem, so if anything being a bit wired/anxious/crazy feeling is more my problem wink

Ever since I've gone on Rifampin, I've gotten a bit more tired at night than I did before. I don't mind it cause I used to have sleeping problems, and now I have no problem falling asleep.

LymePickle
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Date Joined Mar 2014
Total Posts : 2132
   Posted 4/1/2014 9:28 PM (GMT -6)   
Yes, I had some pretty profound fatigue when I took the rifampin treatment, so much that it pretty much knocks me out and I just lay there or sit in a chair. Fatigue is actually a side effect of the drug. But it makes for a nice bartonella treatment because it takes away the anxiety, insomnia, but also makes you tired.

I took it in the morning but then found myself just sitting doing nothing with my eyes closed, so I took it in the evenings and that helped out. I found that it would be the first few hours after taking the dosage that I had the most effect of fatigue.

Are you taking it twice daily or once daily? I did once daily 600 mg right after getting home from work.
Caught Lyme, Bartonella, and Mycoplasma Pneumonia from a friends tear in an unlucky casual contact.
IND 31, IND 39, ++ for 41, and + for 58. Indicating an acute exposure.
Treating with Minocycline (month 1), then added in Banderol & Samento(month 2), then added in Rifampin(month 3), then switched the Rifampin to Septra(sulfa drug)/tinidazole (month 4).
Currently in my 5th month of illness

wilson111797
Regular Member


Date Joined Feb 2014
Total Posts : 39
   Posted 4/1/2014 10:23 PM (GMT -6)   
LymePickle said...
Yes, I had some pretty profound fatigue when I took the rifampin treatment, so much that it pretty much knocks me out and I just lay there or sit in a chair. Fatigue is actually a side effect of the drug. But it makes for a nice bartonella treatment because it takes away the anxiety, insomnia, but also makes you tired.

I took it in the morning but then found myself just sitting doing nothing with my eyes closed, so I took it in the evenings and that helped out. I found that it would be the first few hours after taking the dosage that I had the most effect of fatigue.

Are you taking it twice daily or once daily? I did once daily 600 mg right after getting home from work.


Working up to that, I'm actually at 450MG right now, going up to 600 either tomorrow or the next day. Wish me luck. I plan to eventually take the 600 all at once, on an empty stomach, as I'm heard that's the best way to get the maximum benefit. Sorry to hear it made you that tired, it certainly doesn't make me that exhausted, just a little bit more sleepy.

LymePickle
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Date Joined Mar 2014
Total Posts : 2132
   Posted 4/1/2014 10:37 PM (GMT -6)   
Oh ya it would knock me out for 2-3 hours after. Well kind of sleepy, kind of lazy, kind of just exhausted kind of feeling. That's why I took it in the evening. Maybe it was just the high dose I took? Caused a huge blood spike in the concentration of the drug.

Ya I took mine on an empty stomach too. I am taking most of my antibiotics on an empty stomach except the tinidazole. It says on my pill bottle to take that one with food.
Caught Lyme, Bartonella, and Mycoplasma Pneumonia from a friends tear in an unlucky casual contact.
IND 31, IND 39, ++ for 41, and + for 58. Indicating an acute exposure.
Treating with Minocycline (month 1), then added in Banderol & Samento(month 2), then added in Rifampin(month 3), then switched the Rifampin to Septra(sulfa drug)/tinidazole (month 4).
Currently in my 5th month of illness

Healing98
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Date Joined Jul 2013
Total Posts : 1396
   Posted 4/2/2014 8:26 AM (GMT -6)   
Are you guys having any stomach issues with taking Rifampin on an empty stomach? I am having serious issues with my stomach since I started taking it. I am even considering taking it with food and would be OK with losing the 30% effectiveness if the stomach issues go away. I am taking 300MG once a day and cannot even think of what it will be like if I took it twice a day.

opugirl
Forum Moderator


Date Joined Nov 2012
Total Posts : 3891
   Posted 4/2/2014 1:45 PM (GMT -6)   
I would caution anyone going on antibiotics long term to talk about this with their doctor and look at potential risks vs effectiveness.

My dr absolutely said to take all antibiotics with food b/c otherwise it would destroy my stomach. I did have some gut issues towards the end but overall I was ok.

Just be careful, gut issues are no fun I hear!
Forum Moderator

July 2007 - Deer tick bite w/ physician confirmed EM Rash - given 10 days of Doxy
October 2012 - My world gets rocked January 2013 - My world turns upside down
March 2013 - Igenex +, start treatment with LLMD, LLND, and herbalist
August 2013- Finished all abx, continuing with herbs and homeopathy, Feeling good!

LymePickle
Veteran Member


Date Joined Mar 2014
Total Posts : 2132
   Posted 4/2/2014 2:12 PM (GMT -6)   
I think it is a key to use a probiotic, go on an anti-yeast diet ( low carbs, no sugar), and use nystatin. These are 3 critical things to do during treatment.

I used to include bread in my diet at first. (i was thinking whole grains would be okay), but I got fluffy puffy white stools. I was like whoa that is definitely yeast. So all I did was cut out the bread as well, and now my stools are normal like they were before Lyme disease. (Taking probiotics, nystatin, and no-sugar low carbs). So take a look at your poop and it will tell you the health of your digestive tract.
Caught Lyme, Bartonella, and Mycoplasma Pneumonia from a friends tear in an unlucky casual contact.
IND 31, IND 39, ++ for 41, and + for 58. Indicating an acute exposure.
Treating with Minocycline (month 1), then added in Banderol & Samento(month 2), then added in Rifampin(month 3), then switched the Rifampin to Septra(sulfa drug)/tinidazole (month 4).
Currently in my 5th month of illness

Agent9er
Regular Member


Date Joined Feb 2014
Total Posts : 162
   Posted 4/7/2014 5:51 PM (GMT -6)   
Yes, yes, yes. Made me really tired and always hungry for carbs. I hated taking that med.
Jessica
Tick bite June 2008
Multiple Dr visits until I found a LLMD
Finally diagnosed December 2010
Tested positive for Lyme, Babesia and Bartonella January 2011
Treatment started January 2011

Daughter born with Lyme July 2009
Multiple health issues including seizures
Daughter tested positive for Lyme and Bartonella May 2011
Treatment started May 2011

Son born December 2011 tested negative

camogirl
Regular Member


Date Joined Feb 2014
Total Posts : 66
   Posted 4/7/2014 6:35 PM (GMT -6)   
LymePickle,

You crack me up..... fluffy puffy white stool. That just made my day even though I'm not feeling the greatest today it brought about a loud chuckle. Right after I started the probiotics and a few other supplements I told my husband my stool changed and just look at that crap it's furry! I agree your stool tells a lot about gut issues.
Testing has been completed waiting on results----LLMD appt end of April 2014

pismo10
Regular Member


Date Joined Nov 2016
Total Posts : 32
   Posted 1/9/2018 9:38 AM (GMT -6)   
Rifampin up regulates liver enzymes which then effect cortisol levels(lowering them) causing fatigue.. Well documented side effect.

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 396
   Posted 1/9/2018 10:18 AM (GMT -6)   
woohoo! I am about to start Rifampin and I have high Cortisol. Maybe if it can lower mine I can actually get more energy. We will see.

mpost
Veteran Member


Date Joined Feb 2015
Total Posts : 1527
   Posted 1/9/2018 10:31 AM (GMT -6)   
check your thyroid (start with TSH).

/www.ncbi.nlm.nih.gov/pubmed/16957414
"After the administration of rifampin, TSH increased to 21.3 mU/l. After its administration, Patients 1, 2 and 3 developed hypothyroidism, and received T4. When rifampin was discontinued, the hypothyroidism resolved. After the course of rifampin-therapy had been completed, T4 was discontinued. At-risk patients who receive rifampin may become hypothyroid."

greatguy
Regular Member


Date Joined Dec 2017
Total Posts : 104
   Posted 1/9/2018 10:44 AM (GMT -6)   
Missouri said...
woohoo! I am about to start Rifampin and I have high Cortisol. Maybe if it can lower mine I can actually get more energy. We will see.


Do you have any fear of potential side effects? How do people feel when taking a new drug.

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 396
   Posted 1/9/2018 11:01 AM (GMT -6)   
not so much anymore. I was a little scared for my first antibiotic Ceftin, but it was fine. Then I was a little scared of Flagyl because of the warnings there, but it was fine. I was very uneasy about Babesia meds Clindamycin, Quinine, clarithromycin, plaquenil and the warnings they carry; but has been great so far.

I am pretty sure I will be okay, prob 99% confident I will have no probs with Rifampin, but we will see.

As of right now I am about 3 weeks basically symptom free. I am going to take an antibiotics break after i finish my babesia meds to see if I fall apart. I suspect my symptoms will come back. At that point I will start Rifampin.

greatguy
Regular Member


Date Joined Dec 2017
Total Posts : 104
   Posted 1/9/2018 11:08 AM (GMT -6)   
So no herxes at all? or just very mild herxes?

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 396
   Posted 1/9/2018 1:58 PM (GMT -6)   
I'm not sure I know what a herx is. Flagyl made me feel pretty tired about 2 hours after I took it. I don't know if I would call that a herx. Maybe it was a die-off reaction, maybe it was a side effect.

I was never a sick as some of the others that are around here; or as sick as those I see in wheelchairs or bed bound writhing in pain in documentaries or the news. So I may never herx like those that are super sick.

I also was kind of treating before I actually knew it. When my health was mysteriously degrading a few years ago I cleaned up my diet, quit gluten, quit smoking, quit sugar, quit drinking alcohol, started taking black seed oil, magnesium and other supplements every day. I had actually started treatment without knowing it. By the time I figured out what was actually wrong with my body and started antibiotics, I suspect my microbial load had already been lowered substantially.
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