Doxycycline affecting mood, switch to amoxicillin?

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Fancyhorse
New Member


Date Joined May 2014
Total Posts : 3
   Posted 5/23/2014 12:30 PM (GMT -6)   
Hi guys,

My MD put me on Doxycycline for two months for later stage Lymes-- 100 tab/2x per day. I was real good taking them religiously for 2 weeks even taking on empty stomach for more oomph (pharmacist recommended on empty)... got a little flakey/missing second pill on and off during last 10 days, partly because I take thyroid pills that require they be ingested on empty stomach too so it gets hard to eat and take meds w four doses/day that have to be on empty stomach. I'm advised to wait an hour between thyroid and doxy/ not take together. I don't even eat much but I do need to eat sometimes, I'm more of a grazer anyway, so it's hard to time all this. But also I hate the way the doxy affects me, maybe part of me is resisting and forgetting on purpose.

I swear to you I am not just making this up-- as soon as I got on the doxy I started to feel really anxious and very depressed. I was so happy to get on it in order to get better, but really felt a shift in my body and mind within a day or two as far as just really jarred and uncomfortable mentally, emotionally, physically. I'm not even bringing up how it tears up the digestive tract-- that to me is more tolerable than this yukky depression. I know I have to just suck it up so I can get better but now I have requested my second month of antibiotics be a different antibiotic, also because the 30 days doxy was $300 and my insurance actually wouldn't cover it because too expensive (paid cash, ouch). I got my MD to prescribe Amoxycillan for this second month.. I didn't ask for the one with the booster, should I? I thought I had heard Amoxycillan was better for later stage Lymes, mine would be two years or more, intense fatigue and cognitive impairment being the worst symptoms along w weird erratic heart and breathing stuff. There has been an improvement on all those symptoms on the doxy, tho the first week was seemingly worse.

My question is can I skip the last 3 days Doxy and just get on the next 30 days Amoxycillan? I know you need to be careful w antibiotics to complete the course, but since I'm getting on another full month of Amoxycillan which according to some protocols is almost overkill, I thought it could be ok. Seems I've read it doesn't affect mood like Doxy can in some, but also I was wondering if it's as effective, and should I request the Amoxycillan with the booster and if so what do I ask for? I haven't picked up my prescription yet so could still request a change, my MD is pretty cooperative and sensitive about my concerns.. She is not an LLMD per se but very caring.

Also wondered if others have gotten jarred depressed feeling on Doxy, I just read one of those on-line med help comparisons between Doxycycline and Amoxycillan-- and depression was actually on the list of potential side effects for Doxycycline but not for Amoxycillan.

Also just btw my friend who has LD says Doxycycline is closely related to another antibiotic that was used for acne, Accutane, known to have caused some suicides. I'm thinking that Doxycycline is an effective drug for many things but people should be informed or warned about possible effects on mental health, at least if you have to take it and are feeling depressed or anxious, you will have the knowledge that it's because of the drug, not inherently you, and be able to tough it out.

Post Edited (Fancyhorse) : 5/23/2014 2:39:50 PM (GMT-6)


Fancyhorse
New Member


Date Joined May 2014
Total Posts : 3
   Posted 5/23/2014 3:29 PM (GMT -6)   
I'm surprised not a single answer for a newcomer.

Oh well did my own research and yes there is a definite connection between doxycycline, anxiety, depression and even suicide though I don't know how common the latter is, there are some indidences. If you search it you will see there are these potential side effects. I'm going to stop the doxy today, have 3 day left, took about 27 days of it so hopefully that is adequate, only because I can straight away get on my next month's worth of Amoxycillan (for Lymes).

Lymebabe
Veteran Member


Date Joined Jan 2014
Total Posts : 1260
   Posted 5/23/2014 3:53 PM (GMT -6)   
Fancyhorse, not all of us are available right away. You may need to wait a little to get a response. Three hour window in the middle of the day- not too many people online.

First of all, doxy 100mg 2x day is not enough. The correct dose is 200mg 2x day. If you start killing anything you will have emotional issues because the dying bacteria releases neurotoxins that will affect your brain chemistry which in turn will affect your mood. Yes you can get started on Ammo but I am not sure how effective it will be. What else are you taking? What is your diagnosis? What tests have you done?
Tick 11/2011
First symptoms 9/2012
Incapacitated 8/2013
January 2014 Abx that have not been working, looking for something that will work
Colloidal Silver 2/14 seeing some improvement
Finally a diagnosis! LTT Elispot 2/17/14 Ehrlichia
2/24/14 MTHFR heterozygous for C667T and A1278C
Sponaugle Wellness
My blog about Lyme and my treatment:
harpgirlvslyme.blogspot.com

BarnGurl
Veteran Member


Date Joined Sep 2013
Total Posts : 1426
   Posted 5/23/2014 6:17 PM (GMT -6)   
Hi I did not experience the mental issues with doxy. I did experience slight depression or low mood with ammox. The best imho for depression/mood/irritability was Omnicef. It def improves mood.

Fancyhorse
New Member


Date Joined May 2014
Total Posts : 3
   Posted 5/23/2014 9:23 PM (GMT -6)   
Thanks guys, sorry for my impatience but I was going to pick up the new meds and hoping for feedback. My standard blood test came back negative but my MD said 'this test is very inaccurate' and based on my symptoms and the fact that I had gotten a circular red rash from an attached tick (no ring/bullseye tho), she thought we should treat. I've been having bad cognitive issues and fatigue, erratic heart and breathing too.

But the cognitive stuff has been the worst. I have cared for Alzheimer's and dementia patients for years and some of my behaviors were scarily similar to theirs back when, difficulty driving, finding correct words in conversation, following conversations, scary scary brain fog and confusion. I also went from hardly ever losing stuff to losing my debit and credit cards literally on a weekly basis, as soon as I got the replacements I'd lose them within a few days = maybe 20 canceled cards over several months. I'm a very fit healthy person in my 40's. The red rash was about the size and shape of a silver dollar, appeared shortly after bite as a 'pimple' and kept growing but then after a week or so began to fade, have wondered if it was from a co-infection from tick or actual Lymes. I got it two summers ago, I remember watching it and going hmmmmm that is interesting, but since it never cleared in the middle to create the bullseye I shrugged it off, I have been bitten by deer ticks in OR many times but never was there a rash like this. Have 3 friends who have gotten Lymes in my neighborhood, two w bullseye, one in ER w baffling life-threatening symptoms esp fevers... lucky for her they thought of Lymes at last minute as she had no other indicators. But then she tested positive and got treated.

I have several friends/acquaintances in general locale who have battled Lymes, additional acquaintances to the ones mentioned above, who upon hearing my symptoms thought for sure I might have Lymes, esp the onset of cognitive issues, trouble driving etc. they all go to a LLMD actually a naturopath who is very spendy, I had seen him a year ago and it turned out I had just gotten Hashimotos thyroid disease so we were both quick to blame my symptoms on that, sadly we agreed it was maybe an unnecessary expense to test for Lymes, his specialty, as he uses the much more sensitive test, the one all my friends have tested positive on. I can't afford the expense now but was in a position to a year ago.

Amoxicillin is one of the CDC recommended drugs for Lymes, does not have to be taken on empty stomach, and is not associated w depression in tbe same way Doxycycline is. So I will try it now, I did 27 days of the Doxy and found it awful.

Post Edited (Fancyhorse) : 5/23/2014 8:30:43 PM (GMT-6)


Lymebabe
Veteran Member


Date Joined Jan 2014
Total Posts : 1260
   Posted 5/23/2014 9:27 PM (GMT -6)   
I hear you about the cognitive issues. Could not figure out my AC remote the other day. How pathetic! Hope the meds help! It does sound like Lyme and you are so lucky your doctor actually believes it could be! And yes, this disease is extremely expensive.
Tick 11/2011
First symptoms 9/2012
Incapacitated 8/2013
January 2014 Abx that have not been working, looking for something that will work
Colloidal Silver 2/14 seeing some improvement
Finally a diagnosis! LTT Elispot 2/17/14 Ehrlichia
2/24/14 MTHFR heterozygous for C667T and A1278C
Sponaugle Wellness
My blog about Lyme and my treatment:
harpgirlvslyme.blogspot.com

Healing98
Veteran Member


Date Joined Jul 2013
Total Posts : 1416
   Posted 5/23/2014 10:31 PM (GMT -6)   
Fancyhorse, I have been on Amoxicillin for almost a year and was also on Doxy for a month. I started on Amoxicillin and had great results for the first month. Then I noticed that it was not being as effective as it had been in the beginning because I was getting new symptoms. I continued on it for a few more months and the more I was on it the more symptoms I had. My doctor then prescribed Doxy. I took it for a month and like you, I had horrible GI issues. I did not have anxiety or depression on it but I did get these terrible headaches and the GI issues. I also noticed that although Amoxicillin was not as effective, Doxy was even less. So I went back to Amoxicillin.

Looking back, I now know that what happened was that Amoxicillin was getting rid of Lyme and as I got rid of Lyme I began to get bartonella symptoms. These were the new symptoms that I was blaming on Amoxicillin. I have been treating Bartonella and Lyme together and as I treat them Babesia is now taking front stage and new Babesia symptoms are popping up.

about the anxiety and depression. I am medicine sensitive and had that problem with Clarithromycin, Azythromycin, some high blood pressure medicines, and at the beginning of taking Rifampin.

Some people (like myself) just cannot tolerate certain drug formulations. Some can tolerate a prescription if it is name brand and will have a reaction to the same prescription if it is generic. I have had that happen to me.
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