"A targeted antibiotic can eliminate infections caused by microbes that are resistant to most drugs, experiments in mouse cells suggest.
A team at biotechnology company Genentech in South San Francisco, California, borrowed a concept used in cancer treatment, in which an antibody — a protein designed to attach to particular cells — is connected to a cancer-fighting drug. Such 'antibody–drug conjugates' include Genentech’s Kadcyla (trastuzumab emtansine), which docks onto breast-cancer cells before deploying its cancer-killing payload.
Sanjeev Mariathasan, an immunologist at Genentech, and a large team of co-workers adapted this strategy — which they tested in mouse cells — by gluing an antibody against Staphylococcus aureus (Staph) bacteria to an antibiotic, a modified version of the drug rifampin, which is used to treat tuberculosis."www.nature.com/news/stealth-bomb-antibiotic-vanquishes-drug-resistant-bacteria-1.18696