Here are extracts from a 2008 Scandinavian study which found links between Borrelia and Lymphoma ("MCL" in the text stands for Mantle Cell Lymphoma".)
I will post more examples from the literature soon.
In this large, population-based case-control study, history of Borrelia infection was associated with a nearly 3-fold increased risk of MCL, whether the exposure was self-reported or based on serologic evidence, even in patients with no recollection of Borrelia disease.
An association between Borrelia infection and lymphoma development has been suspected since even before the identification of the spirochete in 1982.21 Accordingly, the occurrence of lymphoma in close proximity to typical skin manifestations of borreliosis, such as ACA and lymphadenosis benigna cutis, has been described in several case reports.22,23
However, other and more tangible evidence of a causal association in certain lymphoma subtypes includes elevated titers of anti-Borrelia antibodies described in individual patients with primary cutaneous B-cell lymphomas (PCBCL),8,9 a higher anti-Borrelia antibody seroprevalence among PCBCL patients than among controls,10 cultivation of the spirochete from skin lesions of 2 PCBCL patients,13 and demonstration of Borrelia DNA in cutaneous B-cell11,12 and T-cell lymphoma lesions24 by polymerase chain reaction (PCR) techniques.
Until recently, there has been little evidence of a Borrelia-lymphoma association in studies outside Europe....
However, serologic evidence of previous Borrelia infection was found in chart reviews in 10 of 23 patients with PCBCL in a recent American investigation.28
In our investigation, there was little solid evidence of a predilection for the skin among the lymphomas that could be suspected to be causally linked with Borrelia infection. Rather, we found evidence to suggest an increased risk of MCLs among those with a Borrelia infection history. We recently demonstrated the presence of Borrelia DNA in 2 nodal lymphomas, 1 of which was an MCL, diagnosed in patients with a documented history of Borrelia infection.16 However, previous studies, albeit with a focus on PCBCL, have suggested associations with risk of MZL, FL, DLBCL, and T-cell lymphomas.12,24,28 Moreover, Borrelia DNA has also been detected in cutaneous B-CLL infiltrates,29 analogous to one of our seropositive patients.
In conclusion, for the first time, we found evidence to suggest an association between Borrelia infection and risk of mantle cell lymphoma. This novel observation requires confirmation, for example, from studies testing for the presence of Borrelia DNA in tumor tissue or from investigations nested in cohorts with access to serologic, register, and/or interview information about Borrelia infection."
Justice will be ours.
For informative articles, please see: www.elenacookblog.wordpress.com (my site www.elenacook.org is currently down due to google reporting it as hacked - hope to have it restored eventually)
www.spirodementia.wordpress.org (Spirochaetal Alzheimer's Association)
www.durayresearch.wordpress.org (Dr MacDonald's Duray research association)