I can take a stab at this. It can be pretty confusing at first, I know I was.
Rife machines fall under the larger category of frequency devices. They are used for different conditions but as far as Lyme treatment is concerned they work because different bacteria species have different resonant frequencies. If you can get them to vibrate at the right frequency they will break up and die, much like the Tacoma Narrows bridge or an opera singer shattering a glass.
Anthony Holland is a professor who is experimenting with finding these MORs (mortal oscillatory rate) for bacteria and recording the effect these frequencies have on them:/www.youtube.com/watch?v=6rGrkz_8t5M
So the Borrelia killing frequencies tend to be the same, for example 612hz (hertz, times the wave goes up and down per second), but different machines use different methods to get the frequency into your body.
The original Rife machine was built with a plasma tube which is a glass tube filled with a noble gas. Basically it's the same as what is used to make neon signs. When a current is input the tube lights up and also acts as an antenna that emits the frequency as a radio wave that travels into the body and hits the bacteria.
The Doug Coil is a machine that is built using large electromagnets. They are turned on and off at the rate of the frequency and strong magnetic field travels several feet away and into your body.
Some machines simply use metal cylinders you hold to transmit the frequency into the body using an electrical current.
Finally one of the ways Spooky can be used is in remote mode. This is a bit more woo woo, and relies on quantum entanglement to transmit the frequency. You put a piece of your DNA into the holder (finger nail clipping) and it will transmit it non-locally to you via quantum entanglement. People swear it works but this method is less proven and I would stick to one of the other ways I previously listed if you're treating Lyme.
So basically a Rife machine is a frequency generator combined with some way of getting the frequency into the body.
I hope this helps, I'd be happy to try to answer any other questions that come up.
You can also find more information on the subject here:www.electroherbalism.com/