C4a levels are High????What is it?Concerned:(

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Dan Mc
New Member

Date Joined Jul 2016
Total Posts : 2
   Posted 7/5/2016 8:48 PM (GMT -6)   
I just received my test results for a ton of blood work and one of the concerns is my C4a levels which are at 24895 and normal should be under 2830 and I also tested positive for Ebstein Barr Virus with Current IGm levels are elevated. She tested for Bortanella and it came back negative. Im a 40 year old male suffering for a sudden on slaught of Panic attacks, severe depression and extreme anxiety with racing thoughts. All this started 3 years ago so my doctor wanted me tested for lymes and other infectious diseases to see if something underlying was causing it. Could my EBV be causing elevated C4a levels or is it possible the I do have lymes and that further testing is neccessary.

Thank you

Veteran Member

Date Joined Mar 2014
Total Posts : 6201
   Posted 7/5/2016 9:14 PM (GMT -6)   
Hi Dan -
Welcome to the forum - sorry you're here but glad you found us.

C4a is an inflammatory marker that some MDs test in order to understand what might be going on with your immune system as an indicator of infection load. So, yes, your number is HIGH! Although, MDs are finding less and less value in testing C4a levels because every person's body is so very different. They've found high levels in very healthy and asymptomatic people and low numbers in very sick people.

Sometimes insurance coverage benefits from tests types of tests.

Here is a good article:

I think your take away is your body is suffering a significant amount of inflammation. It's tough to know if it's due to an infection (like Lyme or Bart) or from your immune system (which creates inflammation in tissues as a way to "punt" stuff out of there that isn't supposed to be there) but this can cause many autoimmune problems as well.

While you're waiting for more testing there are a few things you can do to help manage some symptoms - many of them are caused by inflammation, which you're clearly dealing with and toxin overload.

Not sure if you've done it yet - but as a new member here, it's invaluable for you to read the "New to Lyme?" thread at the top of the page - this will help you with your appts and next steps for testing, etc. And of course please don't hesitate to ask any questions you may have - we're here to help. But this thread also has good info for detoxing, which you should start ASAP regardless of what your diagnosis is. Might help with your symptoms but will help prepare you for treatment, too.

Hopefully others will be along to share their ideas for managing inflammation - I like japanese knotweed and for you, you might benefit from two herbal tinctures that help manage detoxing in the brain - Pinella and Bur Bur.

Regarding the EBV, this is a virus that 90% of adults carry by the time they are 30--but most people are asymptomatic and the virus lies dormant. In people who are very sick or whose immune systems are busy fighting off other microbes, EBV can rear its ugly head and come out of dormant stage to then start causing problems.

VIRAL load
I think it's GREAT that our MD tested for high viral load - many just start treating for lyme & co when the immune system can't handle all that treatment at once.

Neuro-psycho symptoms
I would do further testing of tick-born diseases, give the sudden onset of those specific symptoms. Here is a great video of a lyme specialist psychologist who explained why people who have lyme infections can develop those neuro-psycho symptoms:

Hope this is helpful and hope you find relief -

Lyme Moderator
Chronic late-stage lyme—likely infected in 2000; Clinically dx Mar'14 w/ Babs, + for Bart, CDC + for Bb. Multiple viruses & GI/immune treated first; started AL-Complex in May, A-Bart & A-Bab in July; Nov'14 IV port installed-started Rocephin; added vancomycin Mar'16
DETOX: Pinella/Burbur/Parsley/Milk thistle/Burdock root; cholestyramine / jap. knotweed L-5-MTHFR LMN-V-II probiotic

Forum Moderator

Date Joined May 2014
Total Posts : 33785
   Posted 7/5/2016 9:52 PM (GMT -6)   
Hi Dan - Welcome to our community.

As Pirouette mentioned - its difficult to know if it's from Lyme or bart...

Do you have any other symptoms besides the anxiety, and depression?
Do you remember having a tick bite..or ticks on you? Did you have a bulls-eye rash at one time?

keep us posted - let us know what the further testing shows.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14; added biaxin Sept. 26/14 Disc. amox,added Ceftin Nov. 20th.; Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin); Abx/herb break Apr-July/15; July-mino; Aug. added Rif; Nov. switched mino to biaxin.

Veteran Member

Date Joined Apr 2016
Total Posts : 2473
   Posted 7/6/2016 8:01 AM (GMT -6)   
FWIW - we have experience with high c4a (but not quite that high). Once treated for lymes and etc, the c4a has come down to normal levels. For Kid#1, it actually took several years of treatment for it to normalize.
Kid#1: Extremely sick for several years, very difficult to treat, improved now but not fully well
Kid#2: Very sick now despite being treated for years
Kid#3: Doing very well (ironically had the least and shortest treatment)
Me: Adv Labs positive 2016 (suspected I passed to my kids) - not as sick as others, mostly battling fatigue issues

Krimpet 🍔
Veteran Member

Date Joined Apr 2016
Total Posts : 3275
   Posted 7/6/2016 9:27 AM (GMT -6)   
Welcome Dan. I tested high as well, 15,0000 and some change. I also tested very high on the EBV, so much so that they didn't even give a number. Last test, it's come down some, so that's a good sign. But as P said, 90% of us have it, but the difference is whether it's active or not. Typically the immune system holds it in check, but when that goes awry, well, we can have issues. Personally, that was my first clue that something wasn't right. So, I looked further. I muscle tested positive for a few co-infections as well as blood tested positive for a few. So, while I have never had a positive Lyme test, some of the accompanying critters are present, so I'm just treating for everything.

Again, welcome.
Lyme Moderator

July words of encouragement:
The struggle you're in today
is developing the strength
you need for tomorrow.

New Member

Date Joined Mar 2018
Total Posts : 1
   Posted 3/31/2018 8:54 PM (GMT -6)   
Hi there~ Posting this in case the original poster or someone else reads it. I'm on the other side of hell. I woke up one day with tons of neurological symptoms - extreme agitation in my brain and body, sensory and visual overload, tremors head to toe, severe hypercusis of my ears, nauesea, extreme fatigue, racing thoughts, and more. I ended up curing my symptoms by taking over-the-counter CLARITIN. I'm only 95% now but it helped immensely with the inflammation in my ears and my brain. Within 6 days of taking it I was able to go back to work - after being so sick I was on short term disability at 33 years old. It took weeks but I finally found a good functional medicine doctor to do a massive blood workup. My c4a inflammation marker is high, and while I will never know for sure I am almost positive that it was toxic mold exposure. I tested negative for lyme. In my internet searching I even found a doctor who believes the majority of anxiety/depression cases are related to mold. I think I was exposed to a moldyshower mat in my shower, and the spores somehow got in the steam and into my head. There is nothing else I can think of that would cause such an illness. I really thought I was going to die. I want to make a youtube video, but if anyone happens to see this post, anywhere in the world, I hope it helps them. I highly encourage trying Claritin to help with the inflammation. To this day I don't know why it helps. I did have one doctor tell me I may have a rare disease called mast cell activation syndrome, causing a crazy histamine reaction in my brain and body. That illness is treated (not cured) with antihistamines. If it IS something environmental, the Claritin could help. I really hope someone finds this message. I would possibly not be alive if it wasn't for experimenting with that Claritin. The doctors couldn't explain it. Mold and toxins are no joke. I may never know what I was exposed to but I am happy to be alive and hoping to save other lives as well. I'm also being treated for yeast/candida, and low adrenal and immune function, and low-ish serotonin. (Be vary wary of antidepressants. My doctor is recommending 5HTP instead of an antidepressant.) I hope it helps!

Veteran Member

Date Joined Aug 2017
Total Posts : 1988
   Posted 3/31/2018 9:03 PM (GMT -6)   

Yes, C4a can be a sign of mold exposure. Check out Ritchie Shoemaker's work on mold illness at www.survivingmold.com. Shoemaker's work is science based and backed by lots of data. He has lots of FAQs on the site.

Veteran Member

Date Joined Mar 2014
Total Posts : 5080
   Posted 3/31/2018 9:11 PM (GMT -6)   
Yes, candida (or any gut yeast I suppose) can also elevate C4a.

My c4a went from 55,000 to near 1,350 from a very clean diet and leaky gut protocol. Some other "mold" markers suggested by Shoemaker were fine.
Had initial lyme symptoms late 80's, then again and with bullseye early 90's. Ended ABX for Lyme in 2015. Rebuilding / fine tuning / fixing muscles since then; member "10 Percenters Lyme Club". What an adventure this has been. Hashimotos adds to the enjoyment.
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