Interesting, thanks for this. I will give it a more thorough read when I have time, but for the time being are you saying it doesn't have to be pulsed for toxicity or it doesn't have to be pulsed for efficacy? Because I know that with artemisinin it loses it's efficacy after a week if not withdrawn and it can be neurotoxic long term so I'm not sure which one, or both, you are referring to not being an issue with artemesia. It's interesting though. Really frustrates me when you read half of these studies that end with "*insert herb here* shows promise for treating *insert condition here*. *said herb* needs to be isolated and purified for active constituents". It's like a particular kind of psychosis to take something that already works and not evaluate it as a whole entity with multiple interacting parts that might be more valuable than any isolated ingredient. Just a rant.
It's very controversial, but I know that in my own experience, I used Artemisia annua (also known as Sweet Annie or wormwood) for a full year and never had any real toxicity issues from it or the other herbs I was using. Here's a list of the herbs that I used for that year (and I used Houttuynia for 9 months to heal Bartonella): www.healingwell.com/community/default.aspx?f=30&m=3244272
But, notice I clarify that I use Artemisia annua (the whole herb), not a derivative of it.
Safety of Artemisia Annua: www.cam-cancer.org/The-Summaries/Herbal-products/Artemisia-annua/(merge)www.ncbi.nlm.nih.gov/pubmed/22736625www.webmd.com/vitamins-supplements/ingredientmono-756-sweet%20annie.aspx?activeingredientid=756&activeingredientname=sweet%20annie
Of course, I hope that you do your own research on this before taking it. Once caution is that those that are allergic to ragweed and few others may not tolerate Artemisia Annua, but I'm quite allergic to ragweed and have no issues with using it, so it's best to try it out under a doctor's care if you have those types of allergies.
Herb only treatment for Lyme & Bart ended 12/11 - no active symptoms for 2 yrs -Herb only treatment for Babesia ended 12/12www.healingwell.com/community/default.aspx?f=30&m=2977364
Had Lyme, Bart, Babs, RMSF, Ehrlichia, Myco, Anaplasmosis, EBV
New Lyme case 8/2014 - Healed 1/31/15 - unknowingly had Asymptomatic Babs and Asymptomatic Bart, being treated now though (2/2016)