And for those who walk around with B. Burgdorferi asymptomatically, they probably do not have many spirochetes shedding blebs. Might they have many cystic forms and their immune system is keeping them in dormancy or is an asymptomatic state merely a TH2 dominant TH1/TH2 differentiation and a favoring environment for the reproduction of bacteria and the dissemination of infection? In my understanding, Borrelia Burgdorferi bacteria like to manipulate cytokines. In joint fluid they purposely elevate IL-10 anti-inflammatory cytokine, which would help to RELIEVE arthritis symptoms but would increase spirochete load. However, low IL-10 levels in joint fluid would lead to arthritic symptoms but a markedly less spirochete load. IL-10 is noted to suppress immune system response if elevated.
So feeling better symptom wise might not indicate an eradication of the infection and very well could indicate a dissemination of the infection if treatment was not done appropriately. So, B. Burgdorferi likes to elevate anti-inflammatory cytokines and manipulate the TH1/TH2 differentiation to a TH2 dominance in the most general sentience. Of course, TH2 dominance would help to relieve arthritis symptoms, especially in late stage infections with MS like symptoms. But this would also lead to a welcoming environment for the future spreading of infection.
So, a lot of the later debilitating symptoms involving arthritis are just that. T-cell cytokines, natural killer cells and a strong immune system fighting the bacteria but of course the question becomes, have they already lost the battle?
And this is why I am mainly just reading these threads on this - as I tried to live my life with Lyme undiagnosed, I had periods of very minor symptoms and lived nearly a "normal" life (although I never got rid of all the symptoms) - and yet when I started treating, all manner of havoc broke out in my body. I learned to support and detox my body and things went well - until I got reinfected while living in another area of the US (here in Arkansas, whereas my previous infections came from the West Coast).
I'm not sure what this all means, so I'm still trying to learn....
Herb only treatment for Lyme & Bart ended 12/11 - no active symptoms for 2 yrs -Herb only treatment for Babesia ended 12/12www.healingwell.com/community/default.aspx?f=30&m=2977364
Had Lyme, Bart, Babs, RMSF, Ehrlichia, Myco, Anaplasmosis, EBV
New Lyme case 8/2014 - Healed 1/31/15 - unknowingly had Asymptomatic Babs and Asymptomatic Bart, being treated now though (2/2016)