Bumping in relation to recent thread about
marcons. I knew I'd posted this somewhere recently. I'm really interested in this because the mucous in my airways, from behind my nose all the way down my esophagus is getting more blockage by the week. It's getting harder to swallow, everything in my throat sticks together like rubber cement. And why I started the COPD and Lyme thread.
Right now this is my most worrisome symptom.
This is new territory to me too. I hit google and read several articles. There are more out there.
I found some information that will be of interest to all of us now that you've brought up Marcons. I'm just going to do a copy and paste since this is from a Lyme chat from 6 years ago and any link I post may not work.
"For those of us whom either have positive fungal petris, known or suspected environmental exposures to mold, or have Lyme in which induce biotoxin illness as well as the previously mentioned, then it is my hope you will consider the information I have posted here.
In biotoxin exposure and illness due to that exposure, a pathway in which exists would be the MSH hormone, hemolysins, cytokiene response, leptin receptors, negative feedback pathways, positive feedback pathways, and MARCoNS with biofilm formation and antibiotic resistence within the sinuses. So in whole, this post is about
whole body toxins to include the sinuses and why including them is important in treatment for those with biotoxin illness.
Some sources I have read state that up to 80% of mold exposure patients and thus biotoxin exposure exhibit MARConS colonization of the deep sinuses. Colonization in which causes symptoms due to the biotoxins it produces. Colonization due to the fact that it is considered a normal occupant except for those whom are immunocompromised and so is not considered an infection causing disease, but colonization contributing to the ability of disease to take place. CoNS is Coagulase Negative Staphylococcus. MARCoNS, in my own personal opinion, is Methicillin Resistant Co-agulase Negative Staphylococus and is not normal. Any of us whom have been exposed to numerous antibiotics should consider this information carefully and especially if they are not responding to detoxification and treatments.
MARCoNS is not commonly found in the deep sinuses of normal subjects with intact immune systems. MARCoNS is found in many patients with mold exposure, Chronic Lyme, and biotoxin illnesses. It becomes Methicillin resistant due to the exposures to antibiotics. It is a very crafty organism in developing resistence.
(MSH) Melanocyte Stimulating Hormone, protects the mucous membranes in the nose from colonization of MARCoNS. Fungal exposure, Chronic Lyme, and Biotoxin illnesses deplete MSH. so with the depletion of MSH and resulting MSH deficiency, the sinuses are no longer protected from colonization of these organisms. In MSH deficient patients, I found in one source that most will display multiple resistences to more than one level of antibiotics.
They believe there are two mechanisms in which these bacteria can cause damage to MSH. One is by the production of hemolysins. These are proteins in which lyse red blood cells. The MARCoNS secrete this and cause leakage of iron in the red blood cells, of which it needs to sustain its own life. So not only does a fungal infection within the skin in most cases use iron, but the bacteria do as well. The hemolysins this bacteria creates are then sent out into the bloodstream in which the body then recognizes as foreign and stimulates a cytokiene response. Cytokienes then destroy the leptin receptors on fat cells. This is why many of us experience weight gain instead of the normal disease state of weight loss. Damaging the leptin receptors would then also contribute to the deficiency of MSH. As MSH production depends on Leptin.
The other mechanism is suspected to be Exotoxin A in which are now becoming associated with MARCoNS and are associated with Staph Aureus, and other coagulase positive staph. This toxin is capable of splitting MSH and there for totally destroying its function.
Another important aspect of MARCoNS is their ability to create biofilms. These biofilms are what contain the antibiotic resistence mechanisms of the bacteria and are co-operative in many functions. This biofilm is becoming associated with (CFS) Chronic Fatigue Syndrome. And it is here, that genotypes, the HLA's I have posted on previously are important, because the pathways are markers for the individual whom also may be predisposed to these bacterial biofilm formations. Hence multiple infections over the course of a lifetime and especially when biotoxin illness develops.
MARCoNS thrive in the absence of MSH deficiency caused by fungal exposure, Chronic Lyme, and biotoxin illnesses. MSH is incedibly important to us because it induces a very specific pathway of cytokiene response to the bacteria and kills it or prohibits it from forming in the first place. It is this in which is an example of a NORMAL regulatory pathway in which no longer can function due to the fungal exposure, Chronic Lyme, and Biotoxin illness.
In normal human functioning, this control is through the normal negative feedback pathways. But in mold exposure, Chronic Lyme, and Biotoxin illnesses, the pathway becomes a positive feedback pathway and thus the more MSH becomes deficient, the more problems that will develop. completely abnormal responses controlled by the organisms and not our normal physiologic functions.
The presence of MARCoNS and if it is not addressed, will prevent one in which has experienced mold exposure, Chronic Lyme, and Biotoxin illness from attaining a treatment response and will most certainly prevent one from attaining a cure. Is it the only roadblock, in all probability, no, but I haven't heard anyone talk about
this before. Please consider this.
I know many of you out there have observed in the past about
opensity of whatever Morgellons is, that it seems to hit the face and neck really hard. I also know many of you out there also suffer ear infections, whether middle ear infections or external canal infections or are having conjunctivitis with granules or black specks. This is where the sinuses become very important in this aspect of this disease as well.
Importantly these bacteria and others including gram negative, can also be associated within the mouth and can get in between the teeth as well. All of these structures are connected. Through the teeth, often times the roots pentrate the maxillary sinuses of which then the invading or colonizing organism then has access to all of the sinuses and can disseminate from there. In the deep sinuses, its dark and comfy and incredibly hard to reach with any medication and especially true with biofilm producing organisms. The ears are connected to the sinsues by the Eustachian tube. The eyes are connected to the sinuses by the lacrimal ducts in which drain into the sinuses. And not only are fungii capable of producing granules, so are some bacterias. I am also aware that some of us have made the observation of bumps at the back of our throats, sore throats, diarhhea. All the structures and the connections I have spoken about
connect to the esophagus by the Nasopharynx. Diarhhea? Yes, all that biofilm production contributes to the mucous and we swallow about
8 pints of it in a day, whether we are aware of it or not. I could make a point about
intestinal cleansing and detox but I am sure you can see the connection. I am beginning to question the presence of both and hope those of you interested will also consider them as well.
How do you find out whether this organism is present?
It is called an API-staph culture."
Post Edited (julymorning) : 10/6/2016 5:58:41 PM (GMT-6)