Hi, Girlie. Here are a couple of links. MSH is a big deal, and it's my worst blood test result. I won't be well until we can fix this issue. But, again, I have my LLMD full attention on the matter. I love his support, but I'd love to see progress in how I feel, LoL. Such a roller coaster!
This is an excerpt relating to mold illness, which is a general reason for MSH to tank. But, as I said, we are convinced it is Lyme & most likely so-infections causing my problems. As my LLMD said, the CIRS problems can be from 3 factors. Mold, infection, leaky gut.
MSH - Melanocyte Stimulating Hormone
Normal Range: 35-81 pg/mL
Alpha melanocyte stimulating hormone (MSH) has multiple anti-inflammatory and neurohormonal regulatory functions, exerting regulatory control on peripheral cytokine release, as well as on both anterior and posterior pituitary function.
In mold illness, MSH will be too low in over 95% of patients. This means increased susceptibility to mold illness, ongoing fatigue, pain, hormone abnormalities, mood swings, and much more. MSH is a hormone, called a regulatory neuropeptide, and it controls many other hormones, inflammation pathways, and basic defenses against invading microbes. Without MSH, bad things happen; chronic sleep disorders with non-restful sleep develop, and endorphin production is reduced, so chronic pain follows.
This link is not all on track. It says some good things, but some is incorrect. It is easy to understand though: /selfhacked.com/2016/03/10/alpha-msh-its-role-in-weight-control-autoimmunity-cirs-and-cfs/
This link shows some more info: www.survivingmold.com/diagnosis/the-biotoxin-pathway
There is one specific link I was looking for, but it was one I found by linking to links to links to links... I haven't found it again...