Pulsing Rifampin??

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Snarf
Regular Member


Date Joined Aug 2016
Total Posts : 97
   Posted 1/31/2017 12:30 PM (GMT -6)   
Do others pulse this? I've read a lot of things that said NOT to pulse it. My LLMD has been practicing for many years and is pulsing it 2 days on 1 day off. With how hard it's hitting me my body is thankful for the day off.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32667
   Posted 1/31/2017 12:43 PM (GMT -6)   
I have pulsed it...I did M/W/F two or three weeks on and one week off.

I decided to pulse after reading about Dr. J. (Washington, DC) using a pulsed approach for all infections, not just lyme. I know he is experienced...and highly regarded...treats patients from all over the world.

Other LLMD's are also following Dr. J's protocols of pulsing.

Is your LLMD getting his patients in remission? Does he have good reviews?
If so, I would trust him.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

blueberrymuffin
Veteran Member


Date Joined Mar 2016
Total Posts : 1467
   Posted 1/31/2017 3:02 PM (GMT -6)   
I am taking Rifa, but my LLMD told me to take it every day.
I just hope it will work.
Lyme Disease Moderator

yancync
Veteran Member


Date Joined Nov 2015
Total Posts : 544
   Posted 1/31/2017 4:26 PM (GMT -6)   
DS is currently pulsing rifampin M,W,F 2 weeks on, 2 weeks off. It is working and he gets hit hard when he re-starts it.
Parent of 15yo DS w/ CDC+ Lyme test 11/15, late stage Lyme + mycoplasma, bartonella, babesia. Treating with antibiotics/anti-malerials + Vit D, C, Vit B-12 injections, multivit, milk thistle, dandelion, parsley, cilantro, Burbur/Pinella, L acetyl carnitine, charcoal, mag etc.

Website I started: ParentsofLymeKids.com aka Lyme Disease 101 for Parents

bluelyme
Veteran Member


Date Joined Nov 2015
Total Posts : 4724
   Posted 1/31/2017 5:59 PM (GMT -6)   
Was doing everyday..it burns cortisol 2x as fast too...pulsing.every other...just make sure its paired with something

Rikky1
Veteran Member


Date Joined Jun 2015
Total Posts : 2860
   Posted 1/31/2017 6:02 PM (GMT -6)   
when first taking rifampin i took it every day for a few months. now i'm pulsing rifabutin 4 days on 3 days off. i really need the days off because the days on (and the day after i stop) are quite tough so i'm only getting 2 out of 7 days a week of minimal issues. its great to be me!

Snarf
Regular Member


Date Joined Aug 2016
Total Posts : 97
   Posted 1/31/2017 7:32 PM (GMT -6)   
Blue Lyme - Can you explain about burning cortisol? I already have adrenal issues...will this make it worse?

Snarf
Regular Member


Date Joined Aug 2016
Total Posts : 97
   Posted 1/31/2017 7:35 PM (GMT -6)   
Rikky I hear you! I don't feel like my one day off is enough right now!

LG13
Regular Member


Date Joined Dec 2015
Total Posts : 189
   Posted 1/31/2017 9:20 PM (GMT -6)   
Because it is staying in the system on those shortened pulses does that cover the possible renal failure that might come from restarting? That is the danger, right?

I take it every day. My breathing issues have gotten worse and I wake up nightly after an hour of sleep gasping for breath. Seems to have gotten worse since I started the rifampin a month ago. Really wish I could say definitively what is working or not. Or if it's something altogether different.
Undertreated in '08; Misdiagnosed with bipolar and other psychiatric ailment for seven years
Diagnosed 09/2015 - did various abx starting 9/15-2/16. Switched to DesBio - Bb/Babesia 4/16-7/16, Bartonella 8/16-9/16, EBV 9/16 12/16 GD botanicals, CSA; 1/6/17 started rifampin 600mg/day, doxy 100mg 2x/day

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32667
   Posted 1/31/2017 9:45 PM (GMT -6)   
LG13 said...
Because it is staying in the system on those shortened pulses does that cover the possible renal failure that might come from restarting? That is the danger, right?

I take it every day. My breathing issues have gotten worse and I wake up nightly after an hour of sleep gasping for breath. Seems to have gotten worse since I started the rifampin a month ago. Really wish I could say definitively what is working or not. Or if it's something altogether different.



Could you explain what you mean about renal failure...are you saying starting/stopping/starting..etc can cause renal failure?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

LG13
Regular Member


Date Joined Dec 2015
Total Posts : 189
   Posted 1/31/2017 10:00 PM (GMT -6)   
https://www.ncbi.nlm.nih.gov/m/pubmed/12324902


I don't think it happens a lot but from other forums/posts I have come across that was the fear. All meds have their risks. Just thought this was the reason in this particular case.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32667
   Posted 1/31/2017 10:36 PM (GMT -6)   
Well the good news is all people recovered.

I don't see a lot of information on it...so I'm thinking it is rare.

Dr.J does M/W/F with a week or two off after a couple weeks on...so I guess he doesn't think the risk is high enough to outweigh the benefits of pulsing.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

bluelyme
Veteran Member


Date Joined Nov 2015
Total Posts : 4724
   Posted 1/31/2017 11:08 PM (GMT -6)   
well dr m says people often fail treatment because they cant handle it ..with liver and cortisol.it burns med twice as fast so pain med need be upped , suppliments ,even doxy has shorter halflife because it is a inducer of cytochrome cp245 or some crap. with inflammation of lyme cortisol is already taxed ...however i was feeling the usual liver lully gag but then was having harder time waking like 2 hrs and lots of b vits and ginsing to operate as a human...i would love a day off.. tried houttynia and trying sida , abart was tasty and so is rife daily..i hate bart

lg it may be hitting cpn ,which loves the lungs,its in the stratton protocol...www.cpnhelp.org

Post Edited (bluelyme) : 1/31/2017 10:11:07 PM (GMT-7)


Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32667
   Posted 1/31/2017 11:52 PM (GMT -6)   
bluelyme said...
well dr m says people often fail treatment because they cant handle it ..with liver and cortisol.it burns med twice as fast so pain med need be upped , suppliments ,even doxy has shorter halflife because it is a inducer of cytochrome cp245 or some crap. with inflammation of lyme cortisol is already taxed ...however i was feeling the usual liver lully gag but then was having harder time waking like 2 hrs and lots of b vits and ginsing to operate as a human...i would love a day off.. tried houttynia and trying sida , abart was tasty and so is rife daily..i hate bart

lg it may be hitting cpn ,which loves the lungs,its in the stratton protocol...www.cpnhelp.org


Blue - do you mean Cytochrome P450?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

insomniaaa
Regular Member


Date Joined Apr 2017
Total Posts : 150
   Posted 2/19/2018 11:46 AM (GMT -6)   
If pulsing the rifampin, should I also pulse the minocycline?
And which one of these 2 drugs should I start with?
Should I start with the minocycline and then add in the rifampin about a week later or vice versa?
Thank you.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32667
   Posted 2/19/2018 12:11 PM (GMT -6)   
insomniaaa said...
If pulsing the rifampin, should I also pulse the minocycline?
And which one of these 2 drugs should I start with?
Should I start with the minocycline and then add in the rifampin about a week later or vice versa?
Thank you.


I pulsed the mino with the Rifampin.

The protocol I am waiting to start - all the abx will be pulsed too.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Rikky1
Veteran Member


Date Joined Jun 2015
Total Posts : 2860
   Posted 2/19/2018 8:36 PM (GMT -6)   
you can start either abx, wait a few days, then start the other one.
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