So you sound like the person to ask because I haven't gone deep into this one and don't know the anatomy of nerves very well but GBS variants are generally demyelinating disorders but small fiber nerves don't have myelin? But they also express the same gangliosides? That seems odd to me. I know I have GM1 ab which is common in GBS too
The criterion to meet a pure sensory variant of GBS is rare. Even those of use who are full body, non-length dependent probably would not meet that criterion.
Small fiber nerves have little to no myelin. These are your delta A and C fibers. There are some very good pictures on google image.
It's not that the small fiber nerves express the same gangliosides. It is something that is seen with people who have full body small fiber neuropathy with a quick onset (from Lyme or other causes) also end up positive for gangliosides....that's what grants them IVIG, which improves the SFN.
One of my first symptoms was an abnormal EMG of my peroneal nerve (large fiber damage)....so the autoimmune process was already starting in my body and I had no clue why or didn't know what was coming my way.
I should say mine repair really quickly though. I've had a full blown relapse of body wide neuropathy and back to baseline in two weeks. I attribute some of that success to dietary changes as my first lapse took me 7 months when I was eating SAD. Switched to paleo and rapidly improved, then relapsed (from a swimming pool, the same one that caused my onset). But recovered in two weeks that time. At this point I still have residual neuropathy in my legs but I still have active disease and it responds strongly to antibacterials. I haven't gotten a biopsy. I don't really care to get IVIG as I won't be able to afford it long term and my neuropathy is nowhere the problem it was when this all started.
If your nerve problem repaired that quickly, either you caught it early and/or you didn't have a very bad case (even though I'm sure you felt awful and it was extremely painful) and your dorsal roots were probably not damaged.Sorry I got a bit of poo brain and I'm not following you here. You're saying that it is autoimmune. But you're saying anti-ganglioside AB aren't necessarily causing it? Just coincidental? So whats the primary mechanism and target antigen?
As far as my case I didn't really catch it as I didn't do anything for it aside from change diet months after the fact. Even now if I take antibacterials it improves substantially even though it's been two and a half years. I thought dorsal root damage was implied in SFN but I'm not terribly familiar with this area. My personal opinion on this one was always that the damage was rather reversible if the inflammation was halted
I also find it interesting the distinguishment between full body and length dependent. My understanding was that it was always full body and the distortion per length only reflected the extent of damage. When mine first came on it was all over my body. As I improved it retreated to my legs. If I take a strong antibacterial I will herx that symptom anywhere on my body however. In other words my acute symptoms are all over and my chronic are distal
Thanks for your response. You seem like you know a lot about
this topic and it's been helpful. I sort of saw the connect to GBS and felt it was good enough to move forward but now that the topic is brought up I am interested in understanding it better