Today is going to be my 5th dose of the PZA. I can tell you this stuff is strong! but def working, I'm herxing quite a lot, mostly the usual: fatigue, headache, lymph node pain/burning behind/under ears. So of course detox detox detox! and none of these symptoms are quite as intense as the earlier parts of my treatment journey, because back then my base symptoms were so much worse/intense/crushing and adding the herxing on top of it would always amplify things to the highest agonizing difficulty. Symptoms are so much better now that I only need to deal with herxing and not the heavy weight of regular symptoms that I felt perpetually yoked to, this fact I think makes this latter part of my treatment process/journey more manageable. And I feel so agonizingly close to finishing this thing off and that has me really excited overall.
And I don't mean to get ahead of myself, PZA is a hell of a strong drug and tough on the body. I have my first labwork in a few days to make sure my body is handling it and to check if I can keep staying on the drug. Which is not a guarantee.
I came across this post last night, mentioning that about
8% of Horowitz's lyme/coinfections cases are most difficult to treat. /lymewhisperer.com/2015/12/13/kripalu-closing-in-on-the-8/
Sadly I think I'm in that 8% but I can confirm that dapsone has been very helpful and PZA has the potential as well to really help me (coupled with other proper antimicrobials/supplements). It has been such a long, difficult, ridiculously punishing journey that the prospect of recovery feels almost surreal, but I feel it is possible and I feel it is close. It has taken everything I have, mentally, physically, emotionally to get to this point. I sense I'm in the closing out stages, and am doing my best to close out the disease by attempting to drive a stake through the heart of it (I'm of the opinion that if you can finish it off as best as you can when the opportunity is there it can lessen chance of relapse down the line, just don't want to self-immolate either!). If my body can keep managing these meds then I feel I have a clear pathway to doing it. If things don't work out with this then we will have to improvise something else but I do hope this works out!
Like always, I wish I could have definitive answers on what is the main thing driving disease for me, and what is the main thing that PZA seems to be so effectively hitting in my case. I asked my doc if they thought PZA hit bart since it is intracellular drug, and they said yes they think so. I do also have lyme, but I don't know, the bart seems to be more manifest in my case but no doubt prob some synergy going on between all these infections. But I honestly suspect bart is my main driving infection, and it has been entrenched and severe and I've had it a heck of a long time. Truly epic trying to root this thing out, it is honestly mind-blowing and I'm not sure many outside of this forum could grasp the faintest shadow of comprehension on the magnitude of these diseases or the inordinate herculean difficulty they represent for some of us. I certainly doubt I could have any level of understanding this thing if I didn't go through it (not that I even really understand it anyways!).
I certainly didn't make the decision to take these meds lightly. Thought long and hard. I feel I've run through many of the more conventional treatments for lyme+, many have been extremely helpful and been part of the process to get me to this point of recovery but they haven't brought me to remission. A remission which I 100% believe is possible. I do think these extra meds have potential to get me there, or at least be part of the process to get me much closer, time will tell. As always every patient has to gauge potential benefit/risk of the therapies and I know quite a few people would choose not to take such meds due to the risks and I completely understand that. To me I would always choose to exhaust the safer more conventional options (I use conventional loosely, to include abx, herbals, etc), then if one is still manifesting disease, if your disease has greater intransigence and is still significantly impinging on quality of life, that is when you consider some of these other pathways (if they are available to you, and in this respect I'm very grateful and privileged to have access to this opportunity). There are also other treatments like hyperthermia/abx combo in Germany, ozone, things of that nature that do intrigue me. Personally I chose to go this route b/c I trust my doctor (not blindly though!) and there is slightly more track record with some of these antibiotic therapies even though I find them to be an inelegant solution dragging some serious risks along with them.
Post Edited (sebreg) : 8/6/2017 9:33:15 AM (GMT-6)