Lyme can be very confusing as you well know. 8 years of treatment including IV and hyperthermia is a very comprehensive treatment and one would expect you to have had SOME reaction if Lyme were the culprit. It is always possible that Lyme or a coinfection triggered something else, but if that were the case you would think that Lyme treatment could reverse this process. Lyme is known by many to reactivate EBV, so you are faced with the question did Lyme cause EBV to be a problem for you, or have your symptoms been caused by EBV alone all this time. However over 90% of the population tests positive for EBV exposure, and it very rarely leads to problems in most people on it's own. There is almost always an underlying issue with the immune system that causes EBV to come to the forefront and present issues. There arent many infections that are known to cause EBV reactivation. AIDS and lukemia are among some others, but if you had those for 8 years, you would likely know.
Sometimes you have to go with your gut and fight to pursue what you feel in your heart is the true underlying problem. This is the case with many Lyme patients. I know this may be hard after 8 years of treatment, but you almost have to go back to square one and try to remember what it was like before being sick and try to identify any possible triggers. How do you feel about your symptoms? Did you have a lot of tick exposure? This of course doesnt completely rule out Lyme because you may not always remember the bite, and there is some evidence that it can be transmitted in other ways. I know in my case I didnt have any symptoms until shortly after being bitten by numerous ticks. I had a high white cell count within weeks of being bitten indicating some form of infection, so I have focused heavily on Lyme and I know in my in heart that my issues were at least started by a tickborne infection of some sort, so I fight to pursue this angle. When doctors try to attribute it to something else, I tend to doubt them.
There arent many people on this site who have treated continuously for 8 years. Its hard to give you advice as you have probably heard it all at this point and dont know what to believe. For most people, who come for information to a Lyme site, I would simply recommend to keep treating until they find the right combination, but after trying so long and seeing one of the biggest names in the Lyme world with no progress, I can understand your skepticism at this point. Keep in mind you are asking people who know or strongly believe they have Lyme, and who know how well it can hide and be extremely difficult to prove and diagnose, so we will usually assume Lyme in most cases just based on our own experiences.
You probably wont find anyone here who later found out that their symptoms were unrelated to Lyme, and if they did, they would not continue to visit Lyme sites and post here, they would then begin to pursue treating and learning about something else. Lyme can cause many different health issues from chronic EBV to MS, and officially many of these other diseases have no known cause, so there are a lot of people left wondering what caused their symptoms to begin with. Unfortunately this will continue to be a problem for many as long as the testing remains so unreliable. I do think it is unlikely to test false positive on both the EliSpot and the confirmatory western blot. The CDC uses this 2 step criteria for the exact purpose of eliminating false positives, and for this they are often criticized for actually rendering too many false negatives. You could possibly try further testing like the Advanced Labs culture test.
I'm sure with all the unreliable testing, that some people are treating Lyme or coinfections when in fact they may be suffering from something else. Certain doctors completely dismiss the idea of Lyme and others focus on it too much, so it can be very hard to get a realistic and honest diagnosis.
However, I tend to agree from a clinical standpoint that if you have been treating Lyme for 8 years, it doesnt make much logical sense to treat further especially if you havent realized any progress. But with Lyme you often have to throw logic out the window because this disease doesnt behave logically. You could indeed have Lyme and you could continue to explore why exactly treatment hasnt worked. We know for example, that babesia doesnt respond to Lyme treatment. Could it be mold or a detox issue. There are so many variables taht could impact treatment success This is why it can be helpful to get reassessed by different LLMD's from time to time to get different perspectives, which it sounds like you have done. You can never really definitively rule Lyme in or out, so you have to go with your own clinical suspicions. People do treat Lyme for years on end, but they usually notice SOME progress and continue to treat often times because when they stop, their symptoms will return, which keeps some people treating indefinitely. This doesnt sound like it's the case with you.
That being said, what does your current doc recommend? If he can help to treat your symptoms individually, thats great, but If he just identifies a problem with no given solution, that doesnt help you very much. He may attempt to use antivirals to get EBV in check, but again, in most cases there is an underlying cause for EBV reactivation and if that is the case you want to address that if possible.
You kind of have to go with your gut on this one. Thats all you can really do. Revisit why you suspected Lyme in the first place, and try to eliminate all the variables. If an independent radiologist and several other doctors have diagnosed Lyme, then you might question the one doctor who is saying otherwise. If you continued treating for 8 years, I would assume you probably had a good reason to do so. Try to remind yourself what these reasons were and go from there. It would be refreshing to learn that you were wrong this whole time, but it doesnt seem very likely based on your post, and if the root cause doesnt lend itself to treatable condition, you are still back at square one.