DMSO is incredible stuff! MANY benefits,

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Lapis_29
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   Posted 9/19/2017 4:24 PM (GMT -7)   
I am going to do some research dumping in this thread. I have recently been experimenting with DMSO, internally and externally, and I am telling you its amazing.

HIGHLY underutilized and underestimated. I have had Lyme for probably 35 years only recently realized.

Had no success with multiple treatments except recently with rife using DNA frequencies and now DMSO.

I will post some of the proven benefits.

Lapis_29
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   Posted 9/19/2017 4:28 PM (GMT -7)   
DMSO is a biofilm buster!

It potentiates antibiotics, makinig them much more affecitve.

--------------------------------------------------------

Folia Microbiol (Praha). 2017 May 24. doi: 10.1007/s12223-017-0532-9.

Antibiofilm activity and mode of action of DMSO alone and its combination with afatinib against Gram-negative pathogens.


Biofilms are complex microbial communities that tend to attach to either biotic or abiotic surface. Enclosed in a self-produced extracellular polymeric substance (EPS) matrix, the biofilms often cause persistent infections. The objective of this study was to investigate the antibiofilm activity of dimethyl sulfoxide (DMSO) and afatinib against Gram-negative pathogens. Test microorganisms used in this study were Escherichia coli ATCC 1299, Pseudomonas aeruginosa ATCC 10145, and Salmonella typhimurium ATCC 14028. Biofilms were developed in 96-well microplate at 37°C for 24 h. Following removal of non-adherent cells, analysis of biofilm viability, biofilm biomass, and extracellular polymeric substances (EPS) matrix were performed using resazurin assay, crystal violet assay, and attenuated total reflectance fourier transform infrared (ATR-FTIR) spectroscopy, respectively. Bradford protein assay was conducted to determine the total amount of EPS proteins. The results demonstrated that both 32% DMSO alone and its combination with 3.2 μg/mL afatinib were effective in killing biofilm cells and reducing biofilm biomass. IR spectral variations of EPS matrix of biofilms in the range between 1700 and 900 cm-1 were also observed. Reduction in EPS proteins verified the chemical modifications of EPS matrix.

In conclusion, 32% DMSO alone and its combination with 3.2 μg/mL afatinib showed remarkable antibiofilm activities against Gram-negative pathogens.

It was suggested that the biofilm inhibition was mediated by the chemical modification of EPS matrix.[img][/img]

Post Edited (Lapis_29) : 9/19/2017 5:32:31 PM (GMT-6)


astroman
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   Posted 9/19/2017 4:34 PM (GMT -7)   
BUT...........its a chemical solvent. You arent digesting it are you?

Some like it for topical over muscle pain. I have some, did nothing (topically), but does for others.
Ended ABX for Lyme in 2015. Rebuilding / repairing / fine tuning since then. What an adventure this has been.

Lapis_29
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   Posted 9/19/2017 4:42 PM (GMT -7)   
dmso destroys pathogenic bacteria ability to quorum sense, thus making them easier to kill

---------------------------------------------

Potential Use of Dimethyl Sulfoxide in Treatment of Infections Caused by Pseudomonas aeruginosa.

Guo Q1, Wu Q1, Bai D1, Liu Y2, Chen L1,3, Jin S1, Wu Y1, Duan K4,3.

Abstract

Dimethyl sulfoxide (DMSO) is commonly used as a solvent to dissolve water-insoluble drugs or other test samples in both in vivo and in vitro experiments. It was observed during our experiment that DMSO at noninhibitory concentrations could significantly inhibit pyocyanin production in the human pathogen Pseudomonas aeruginosa Pyocyanin is an important pathogenic factor whose production is controlled by a cell density-dependent quorum-sensing (QS) system. Investigation of the effect of DMSO on QS showed that DMSO has significant Quorum sensing antagonistic activities and concentrations of DMSO in the micromolar range attenuated a battery of QS-controlled virulence factors, including rhamnolipid, elastase, and LasA protease production and biofilm formation.

Further study indicated that DMSO inhibition of biofilm formation and pyocyanin production was attained by reducing the level of production of an autoinducer molecule of the rhl QS system, N-butanoyl-l-homoserine lactone (C4-HSL). In a mouse model of a burn wound infection with P. aeruginosa, treatment with DMSO significantly decreased mouse mortality compared with that for mice in the control group. The capacity of DMSO to attenuate the pathogenicity of P. aeruginosa points to the potential use of DMSO as an antipathogenic agent for the treatment of P. aeruginosa infection. As a commonly used solvent, however, DMSO's impact on bacterial virulence calls for cautionary attention in its usage in biological, medicinal, and clinical studies.

Lapis_29
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   Posted 9/19/2017 4:55 PM (GMT -7)   
When combined with antibiotics, DMSO will convert bacteria which are resistant to a given antibiotic to being sensitive to that same antibiotic and probably a 80 to 90 per cent solution of DMSO will be required in order to be clinically useful ( Pottz, Rampey, Benjamin,1967). DMSO has been used to transport antibiotics to hard-to-reach areas of the body with excellent results, such as the bone marrow and brain (Sanders, 1967).

DMSO can dissolve a virus protein coating, leaving the virus core unprotected with its nucleic acid exposed to the immune system. Applied topically, it alleviates the lesions that occur as a result of Herpes Zoster, shingles (Morton, 1993).

Placed into the nostrils or topically in the face, DMSO can open blocked sinuses within a few minutes and it has been used with sucess in patients with polyps (Marvin, 1967).

https://www.sott.net/article/228453-DMSO-The-Real-Miracle-Solution

Lapis_29
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   Posted 9/19/2017 5:13 PM (GMT -7)   
astroman said...
BUT...........its a chemical solvent. You arent digesting it are you?

Some like it for topical over muscle pain. I have some, did nothing (topically), but does for others.


water also is a solvent..so what?

yes I am ingesting it. its incredibly non-toxic. I do about 30 ml a day, wouldn't recommend much more than that, but who knows?

Girlie
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   Posted 9/19/2017 5:31 PM (GMT -7)   
I have read testimonies of people using it orally...but can you get a Food Grade quality DMSO?

That would be my concerns.


I've mentioned on here before that my husband swears by it...for 'fixing' his injuries on more than one occasion. (topically)


He worked with someone whose father had stomach cancer and was told there was no hope.
He drank it. I don't know what the dilution was though. EDITED TO ADD: It cured him.

**** I am not advocating anyone take it internally...as my husband only used it with success topically ****
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 9/19/2017 10:47:16 PM (GMT-6)


Lapis_29
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   Posted 9/19/2017 5:59 PM (GMT -7)   
Girlie said...
I have read testimonies of people using it orally...but can you get a Food Grade quality DMSO?

That would be my concerns.


I've mentioned on here before that my husband swears by it...for 'fixing' his injuries on more than one occasion. (topically)


He worked with someone whose father had stomach cancer and was told there was no hope.
He drank it. I don't know what the dilution was though.

**** I am not advocating anyone take it internally...as my husband only used it with success topically ****


Yes, you MUST get PHARMACEUTICAL GRADE DMSO!

many place will claim that sell it but most dont. Pharma grade had NO SMELL at all. none. If your DMSO smells of anything, even slightly, it has impurities. I would never use anything but pharma grade inside or outside the body.

"dmso store" online is great, that is where i get mine, not sure if its okay to post the link or not.

Girlie
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Total Posts : 27972
   Posted 9/19/2017 6:06 PM (GMT -7)   
oops - I forgot to welcome you to our community, Lapis.


It would be best in glass containers, as well.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Lapis_29
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Date Joined Sep 2017
Total Posts : 523
   Posted 9/19/2017 6:08 PM (GMT -7)   
Girlie said...
oops - I forgot to welcome you to our community, Lapis.


It would be best in glass containers, as well.


thank you, yes glass is best.

Rikky1
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   Posted 9/19/2017 6:30 PM (GMT -7)   
Lapis I posted about DMSO a while ago. It's very big overseas and used both orally and topically. I can tell you its the real deal. I turned my mother onto it who uses it for her hip joint that is so worn down its bone on bone and provides more relief than any other thing she's tried including NSAIDs, etc.

I was doing 1/4tsp 2x/day for a while.

Yes you must buy the pharmaceutical grade 99.99%. You don't have to get it in glass but most do.

This stuff is insanely cheap.

astroman
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   Posted 9/19/2017 7:16 PM (GMT -7)   
Lapis_29 said...
astroman said...
BUT...........its a chemical solvent. You arent digesting it are you?

Some like it for topical over muscle pain. I have some, did nothing (topically), but does for others.


water also is a solvent..so what?

yes I am ingesting it. its incredibly non-toxic. I do about 30 ml a day, wouldn't recommend much more than that, but who knows?


"So what?" .......Ha Ha ........hey your welcome LOL

Obviously not comparable to just water. After reading the bottle I have, ingesting seems like the last thing to do, it does say 99.9% pure. Guess its their way of shedding all responsibility.

Rikky1
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   Posted 9/19/2017 7:50 PM (GMT -7)   
astro you should learn more about it from doctors/naturopaths who've been using this for all sorts of things for decades overseas before settling on your position. i know a few personally and its done things nothing else even came close to.

MAF249
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Date Joined Jan 2017
Total Posts : 119
   Posted 9/19/2017 9:40 PM (GMT -7)   
The problem is that in the study for biofilms the concentration of dmso is 32%. Much higher than what would be reached in the blood. Not saying that it wouldn't help but its not direct evidence.

I am going to get some though and see if it helps.

Has anyone combined it with antibiotics?

Girlie
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   Posted 9/19/2017 9:55 PM (GMT -7)   
It's a byproduct of wood pulp.


When my mom was in the hospital dying from cancer many years ago, we actually purchased a big jug of it because of the testimony of the guy who cured his stomach cancer with it.

But, we chickened out. We would have had to put it in her IV drip and I was worried that someone would find out and we'd be charged after she passed away.


I'm not going to take it orally. I did use it on my left hand when my nerve pain was so bad (before I was diagnosed) - but it didn't seem to help. I only tried it twice....probably not enough.

My husband keeps nagging me to try it on my nerve pain. He recently used it on his leg when he had some random nerve pain show up....it was gone after two applications.
Maybe it would have gone away anyway....
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 9/19/2017 11:00:12 PM (GMT-6)


Lapis_29
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   Posted 9/20/2017 9:17 AM (GMT -7)   
Girlie said...



I'm not going to take it orally. I did use it on my left hand when my nerve pain was so bad (before I was diagnosed) - but it didn't seem to help. I only tried it twice....probably not enough.

My husband keeps nagging me to try it on my nerve pain. He recently used it on his leg when he had some random nerve pain show up....it was gone after two applications.
Maybe it would have gone away anyway....


I have had incredible success addressing severe sciatica in my lower back.

I used DMSO at first, plain not diluted, which helped. then i added topical B12 along with the DMSO. amazing...finally I had pain relief and can now sleep without waking up every 2 - 3 hours due to pain.

Only use pure B12 with no additives or flavoring, I use 'bio-alternatives' brand. Also combine with oral fat soluble B1 called allithiamine, 3 - 5 caps a day. This is NOT benfotiamine which is a BS product.

Lapis_29
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   Posted 9/20/2017 9:23 AM (GMT -7)   
astroman said...
Lapis_29 said...
astroman said...
BUT...........its a chemical solvent. You arent digesting it are you?

Some like it for topical over muscle pain. I have some, did nothing (topically), but does for others.


water also is a solvent..so what?

yes I am ingesting it. its incredibly non-toxic. I do about 30 ml a day, wouldn't recommend much more than that, but who knows?


"So what?" .......Ha Ha ........hey your welcome LOL

Obviously not comparable to just water. After reading the bottle I have, ingesting seems like the last thing to do, it does say 99.9% pure. Guess its their way of shedding all responsibility.


You can put this in an IV and administer pure DMSO to the blood stream. Seriously, that how safe this stuff is.

-------------------------------------------------------------------

Rev Clin Basic Pharm. 1985 Jan-Jun;5(1-2):1-33.
Medical use of dimethyl sulfoxide (DMSO).
Swanson BN.
Abstract

DMSO is a clear odorless liquid, inexpensively produced as a by-product of the paper industry. It is widely available in the USA as a solvent but its medical use is currently restricted by the FDA to the palliative treatment of interstitial cystitis and to certain experimental applications. Cutaneous manifestations of scleroderma appear to resolve (albeit equivocally) following topical applications of high concentrations of DMSO. A limited number of small clinical trials indicate that intravenous DMSO may be of benefit in the treatment of amyloidosis, possibly by mobilizing amyloid deposits out of tissues into urine. Dermal application of DMSO seems to provide rapid, temporary, relief of pain in patients with arthritis and connective tissue injuries. However, claims for antiinflammatory effects or acceleration of healing are currently unwarranted. There is no evidence that DMSO can alter progression of degenerative joint disease, and, for this reason, DMSO may be considered for palliative treatment only and not to the exclusion of standard antiinflammatory agents. The safety of DMSO in combination with other drugs has not been established; neurotoxic interactions with sulindac have been reported.

In experimental animals, intravenous DMSO is as effective as mannitol and dexamethasone in reversing cerebral edema and intracranial hypertension. An initial clinical trial in 11 patients tends to support this latter application.

DMSO enhances diffusion of other chemicals through the skin, and, for this reason, mixtures of idoxuridine and DMSO are used for topical treatment of herpes zoster in the UK.

Adverse reactions to DMSO are common, but are usually minor and related to the concentration of DMSO in the medication solution. Consequently, the most frequent side effects, such as skin rash and pruritus after dermal application, intravascular hemolysis after intravenous infusion and gastrointestinal discomfort after oral administration, can be avoided in large part by employing more dilute solutions. Most clinical trials of DMSO have not incorporated the components of experimental design necessary for objective, statistical evaluation of efficacy. Randomized comparisons between DMSO, placebo and known active treatments were rarely completed.

Final approval of topical DMSO for treatment of rheumatic diseases in particular will require a multi-center, randomized comparison between high and low concentrations of DMSO and an orally-active, nonsteroidal antiinflammatory agent.(ABSTRACT TRUNCATED AT 400 WORDS)

Lapis_29
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   Posted 9/20/2017 9:29 AM (GMT -7)   
here is a clinic that offers IV DMSO treatments. I am looking for one in my area.

http://coylechelationclinic.org/dmso.htm

Girlie
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   Posted 9/20/2017 11:15 AM (GMT -7)   
I didn't realize topical B12 existed...
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

The Warrior
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Date Joined Jun 2017
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   Posted 9/20/2017 11:29 AM (GMT -7)   
Girlie said...
I didn't realize topical B12 existed...


It does, and I was really excited when I got it. Until I used it and it gave me intense fatigue and a brain fog.

It's probably because it was B12 in the methylcobalamin form and having the CBS mutation that's not the right kind for me.

I do think that transdermal absorption is effective and also underrated. I use magnesium oil every day and it does make a huge difference.
First symptoms in 2014.

Diagnosed in May 2017:
•Borrelia Burgdorferi
•Bartonella
•Babesia
(DNAConnexions PCR)

Other Conditions:
•MTHFR mutation

Started treatment in May 2017:
•Dr. Zhang's herbal protocol

Lapis_29
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   Posted 9/20/2017 1:23 PM (GMT -7)   
Girlie said...
I didn't realize topical B12 existed...


you can buy topical B12, but the stuff I make if WAAAY more affective.

I use liquid B12 with no additives, then rub that on my skin, then rub DMSO on top of that. Incredible results. Much more affective than the expensive B12 patches and whatnot. Also, cheaper. I honestly think its more affective than the prescription B injections.

Lapis_29
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   Posted 9/20/2017 1:44 PM (GMT -7)   
DMSO has incredible anti inflammatory properties. This study shows that topically applied DMSO penetrates deep into the joint of horses and dramatically reduces swelling and inflammation. I am sure it does the same in humans.

---------------------------------------------------------

Am J Vet Res. 1998 Sep;59(9):1149-52.

Anti-inflammatory effects of topically applied dimethyl sulfoxide gel on endotoxin-induced synovitis in horses.

Smith G1, Bertone AL, Kaeding C, Simmons EJ, Apostoles S.

Abstract

OBJECTIVE:
To evaluate the effect of topically applied dimethylsulfoxide (DMSO) on lipopolysaccharide (LPS)-induced synovitis in the mid-carpal joint.

ANIMALS:
6 sound, healthy, adult horses (12 carpi).

PROCEDURE:
In a double-blinded, crossover, paired study with a 1-week washout period, mid-carpal joints were allocated to group 1 (DMSO, n = 6) or group 2 (control, n = 6). Each joint was injected with 1.3 ml (0.0125 ng/dl) of LPS to induce synovitis. For group-1 joints, DMSO gel (15 g; 90%) was applied after injection of LPS and at 12-hour intervals for 60 hours. Joints of group 2 received LPS, but not DMSO gel. All horses were evaluated by serial lameness examinations and synovial fluid analyses (total and differential WBC count and total protein concentration) at 12-hour intervals for 60 hours after LPS injection. Plasma and synovial fluid were obtained at baseline and 36 hours to document presence of DMSO.

RESULTS:
Mean WBC concentration was significantly (P < 0.05) lower in group-1, compared with group-2 joints, at 24 hours and had a trend to be lower at 36 hours. Mean total neutrophil count was significantly lower in group-1, compared with group-2 joints at 24 hours. In group-1 joints, DMSO was detected by use of gas chromatography in the synovial fluid of 5 of 6 joints and in plasma from 1 of 6 horses.

CONCLUSION:

Topically applied DMSO penetrated into synovial fluid in sufficient quantities to be detected and to decrease joint inflammation.

Lapis_29
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   Posted 9/20/2017 1:52 PM (GMT -7)   
Pro-inflammatory cytokines cause all kinds of pain and swelling issues. Proinflammatory cytokines are produced predominantly by activated macrophages and are involved in the up-regulation of inflammatory reactions. There is abundant evidence that certain pro-inflammatory cytokines are involved in the process of pathological pain.

Guess what disables Pro-inflammatory cytokines? DMSO

-------------------------------------------

DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis

Abstract

Dimethyl sulfoxide (DMSO) is currently used as an alternative treatment for various inflammatory conditions as well as for cancer. Despite its widespread use, there is a paucity of data regarding its safety and efficacy as well as its mechanism of action in human cells.

Herein, we demonstrate that DMSO has ex-vivo anti-inflammatory activity using Escherichia coli- (E. coli) and herpes simplex virus-1 (HSV-1)-stimulated whole human blood.

Specifically, we found that between 0.5%– 2%, DMSO significantly suppressed the expression of many pro-inflammatory cytokines/chemokines and prostaglandin E2 (PGE2). However, a significant reduction in monocyte viability was also observed at 2% DMSO, suggesting a narrow window of efficacy. Anti-inflammatory concentrations of DMSO suppressed E. coli-induced ERK1/2, p38, JNK and Akt phosphorylation, suggesting DMSO acts on these signaling pathways to suppress inflammatory cytokine/chemokine production. Although DMSO induces the differentiation of B16/F10 melanoma cells in vitro, topical administration of DMSO to mice subcutaneously implanted with B16 melanoma cells was ineffective at reducing tumor growth, DMSO was also found to block mouse macrophages from polarizing to either an M1- or an M2-phenotype, which may contribute to its inability to slow tumor growth.

Topical administration of DMSO, however, significantly mitigated K/BxN serum-induced arthritis in mice, and this was associated with reduced levels of pro-inflammatory cytokines in the joints and white blood cell levels in the blood.

Thus, while we cannot confirm the efficacy of DMSO as an anti-cancer agent, the use of DMSO in arthritis warrants further investigation to ascertain its therapeutic potential.

Lapis_29
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   Posted 9/21/2017 8:16 AM (GMT -7)   
So I have SEVERE pain, muscles wasting and weakness in my shoulders, arms, and legs due to lyme and coinfections, many years undiagnosed.

As I continue to use DMSO topically slowly the pain and weakness is dissipating. Sometimes I use B12 topically along with the DMSO, sometimes not. Each day I slowly improve.

Also have pulsatile tinnitus in both ears. Decided to do DMSO ear drops, straight DMSO not dilluted. Wonderful! tinnitus gradually subsiding day by day! Almost makes me want to cry, not having to listen to 'woosh wooosh wooosh woosh' allllll f-in day long.

posted earlier in thread about sciatica and how DMSO cleared that up.

Still have a long way to go, but improving so all you can ask for.

Also I am continuing to do Rife treatments using the DNA frequencies and I am 100% convinced the DMSO weakens pathogens and makes the rife 10X more effective. Likely due to the quorum sensing disruption and viral coating dissolving properties of DMSO.


also, the more you apply this stuff to the skin, the skin gradually toughens up and the burning and redness diminishes. You can use aloe vit E lotion if the skin irritation bothers you.

I hope more people try this because it is truly amazing stuff.

Lapis_29
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   Posted 9/21/2017 8:25 AM (GMT -7)   
WARNING!

there is a DMSO vendor on amazon, they have a picture of a tree on their label.

DO NOT USE THIS PRODUCT!

these idiots decided to put their DMSO in a #7 plastic container, which DMSO will leach. Basically you will be poisoning yourself with plastic if you use this product.

They also claim to be 99.9% pure. BS! this smells weird, DMSO should have NO SMELL at all. if it smells, dont use it.

someone even posted a review on amazon.

---------------------------------------

"I am a chemical engineer. The plastic bottle for the DMSO is a number 7 plastic called polycarbonate. This plastic is incompatable with DMSO as DMSO can dissolve some of the plastic or components in the plastic and take this plastic into your body and deposit it there causing long term problems. The only safe plastics are number 1, 2, 4, 5 or glass. Do not use this product on or in the body!"
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