If you don't respond to these antibiotics you should look into other issues as well:
Thyroid + Adrenals
Bartonella can become resistant if you don't respond to Rifampin, Rifabutin might be an option to switch. And take bactrim next to it. You can drop the azithro and keep doing the mino.
Pulsing tinidazol is not necessary on the bactrim, rifabutin, minocycline combination. You could try dapsone instead of tinidazol or PZA if you really want another persister-drug next to it.
tinidazole is a cyst buster and is often prescribed by LLMD's.
I wouldn't drop that one.Tinidazole only works as a cyst drug on Borrelia. But Lewis already showed you cannot achieve MICs to have effect on Borrelia persisters with metro/tini in vivo. I see the study is already shared here. Bartonella doesn't have these enzymes that convert Tinidazole or Metronidazole into active compounds.
I've written about
Since Dapsone also works on Lyme biofilms and persisters in combination with rifampin and minocycline I wouldn't mind the tinidazole. (Zhang has found this 3 drug oral combination to be most effective against Borrelia persisters.)
Zhang also found bactrim has effects against Borrelia persisters (also a sulfa-drug just like Dapsone).
So combining bactrim, rifampin, minocycline and pulsing dapsone instead of tinidazole would work better against all involved infections.
It covers intracellular Bart, Borrelia in all its forms, will have effects against Babesia (Dapsone, minocycline, bactrim and rifampin all have effects on Babesia) and Dapsone also has effects against auto-immunity and is a good drug for certain skin and mouth ulcers...
These are the newest insights into treatments...
Post Edited (LymeBasics) : 9/24/2017 3:49:23 PM (GMT-6)