If an invader is drug resistant does the drug have any impact temporarily?

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ChickenArise
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Date Joined Nov 2015
Total Posts : 1227
   Posted 11/7/2017 10:51 AM (GMT -7)   
I recently attempted to taper Fluconazole to weekly. As the Fluconazole leaves my system the fungal like symptoms which mirror tinea and Bartonella as well as random stinging begin to return. If I take it once every 3 days then enough seems to stay in my system to keep symptoms at bay.

I tolerate the Fluconazole well but I know the chance that it will resolve my issues is growing slimmer as my use approaches 18 months.

I am going to return to every 72 hour dosing but explore trying to get some Aphoteracin B. I think they have an oral form in Europe.

I wonder if there are any symptoms that can distinguish mold from Bartonella.

My question is, if something is drug resistant, can the drug still have a positive impact like I experience with Fluconazole?

The bonus question is, what is the longest you know of anyone staying on this drug and did they achieve a cure or destroy their liver?

2014 Mold Sick,2015 Clinical Lyme and co.,2016 Morgellons,2017 Remission
YT (for now): www.tinyurl.com/CHIARISE
Twitter: @ClintFromNYtoVA
Blog: www.fascinatingtimetobealive.blogspot.com/
"Give me the material that I can to apply critical thinking or blind faith to. I'm all about the possibilities!"
“The privilege of a lifetime is to become who you truly are"

Pirouette
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Date Joined Mar 2014
Total Posts : 6109
   Posted 11/7/2017 3:10 PM (GMT -7)   
CA -

I'm not sure what you're asking.

Only a few sx overlap between yeast/fungus and bart. Fluconazole is effective against y/f - not the other two. There were some studies suggesting there might be some effectiveness with Lyme but I think it's inconclusive.

The thing about yeast/fungus is that they can grow resistant to antifungals, just like bacteria can to antibiotics. You really don't want to pulse it like that - half life is appx 20-50 hrs.

If the y/f grows resistant to the fluconazole, no it will bo longer be effective.

So - what else are you doing to get the y/f back in balance? Is your GI health in good shape? Restrictive diet? Are you taking a good GI binder?

Can you explain the associated symptoms?

I was on Ketoconazole for the first two years (I think) and then went off it, was able to stay off it. My liver enzymes remained good as long as I was on milk thistle seed AND burdock root. I was also on an antiviral Rx in addition to two IV abx... so that was a lot for the liver/kidneys to handle and I did OK. What are you doing to support liver?

-p
LYME FORUM MODERATOR

Chronic late-stage lyme—likely infected in '98; Clinically dx Mar'14 w/ Babs, Fry Labs+ Bart-like, CDC+ Bb. First treated 4-5 viruses, GI/immune. Herbal antimicrobials in May; IV port-started Rocephin in Nov; added vancomycin Mar'16;
DETOX: Pinella/Burbur/Parsley/Milk thistle/Burdock/Red root; Samento/Banderol/Enula; JK/Turmeric; BFM-1; antifung; many supps; cholestyramine

ChickenArise
Veteran Member


Date Joined Nov 2015
Total Posts : 1227
   Posted 11/8/2017 1:49 PM (GMT -7)   
I am attempting to determine if and when Fluconazole is futile against this fungal like invader that acts like Bart. Fluconazole keeps the symptoms at bay and I make progress but when I stop it or reduce it to weekly then symptoms like itchy pink scally patchy face skin and mild stinging biting sensations come back.

I am trying to determine if this is indicating resistance to the drug or if I just need to remain on it longer.

If there is resistance then I should try Ketoconazole or Amphoteracin B. Both are toxic as heck and I would rather not.

I am doing liver detox much like yourself but I think it grows back the moment Fluconazole is reduced to less than 72 hours and levels decline. Could it work at keeping loads down so that I remain asymptomatic but is unable to kill it?

I am also trying to bind mold with Chlorella, Red Raspberry Leaves, Bentonite Clay, and Modified Citrus Pectin. I take Fucoidan for the mycotoxins.

I also have been back on ACV for close to a month. I went the nystatin route and herxed alot. Itraconazole and Terbinafince did all that they could do and then did no more.

I am having a difficult time determining if it is dimorphic fungi or Bart that I cannot seem to clear.

I would think the Bart symptoms are closer to what I am experiencing but the similarities to mold poisoning make it difficult to distinguish. If only there were something that Bart will cause that mold would not maybe I could be sure.

There was no herx from Rifampin and so far very little reaction to the herbals. There was no herx from Nitazoxanide but when I first used Tinidazole there was.

At least one of the Herbals I am using is W.E.'s MYCO formula which sounds like a fungal treatment.

2014 Mold Sick,2015 Clinical Lyme and co.,2016 Morgellons,2017 Remission
YT (for now): www.tinyurl.com/CHIARISE
Twitter: @ClintFromNYtoVA
Blog: www.fascinatingtimetobealive.blogspot.com/
"Give me the material that I can to apply critical thinking or blind faith to. I'm all about the possibilities!"
“The privilege of a lifetime is to become who you truly are"

Georgia Hunter
Veteran Member


Date Joined May 2012
Total Posts : 1997
   Posted 11/8/2017 7:03 PM (GMT -7)   
It is quite possible that you have problems with biofilms and that the Fluconazole kills the fungi it comes in contact with, it just can't get to all of it. Biofilms release bacteria and fungi at periodic rates to ensure constant colonization potential.

Rikky1
Veteran Member


Date Joined Jun 2015
Total Posts : 2522
   Posted 11/8/2017 7:05 PM (GMT -7)   
worth exploring biofilms as georgia said. you can try xylitol and lactoferrin when you take the diflucan to see if over time that knocks it out. i would pulse the biofilm busters to keep the buggers off guard.

ChickenArise
Veteran Member


Date Joined Nov 2015
Total Posts : 1227
   Posted 11/10/2017 9:21 AM (GMT -7)   
ok will add back xylitol and mannitol and will add Erythrtol at times but I did a long stretch of the first two for a while treating with Fluconazole.

Appreciate the input.

2014 Mold Sick,2015 Clinical Lyme and co.,2016 Morgellons,2017 Remission
YT (for now): www.tinyurl.com/CHIARISE
Twitter: @ClintFromNYtoVA
Blog: www.fascinatingtimetobealive.blogspot.com/
"Give me the material that I can to apply critical thinking or blind faith to. I'm all about the possibilities!"
“The privilege of a lifetime is to become who you truly are"

Georgia Hunter
Veteran Member


Date Joined May 2012
Total Posts : 1997
   Posted 11/11/2017 12:30 AM (GMT -7)   
If you have decreased perfusion of blood due to copper imbalance (or other factors), the antibiotics or antifungals won't access certain areas of the extracellualr matrix. Exercises to increase blood flow to the joints would be beneficial.
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