By translocation, are you referring to "leaky gut?" Is there something we can do to counteract this pH change you are referring to? If so, what exactly would that correct - only the pH change? or the act of translocation as well?
By periphery, am I correct in that your saying if you indeed have "leaky gut," then increasing "good" bacteria in the gut is going to benefit the gut itself but cause problems elsewhere because it is leaking outside the walls of the gut (the periphery)?
Are you saying that IF you have "leaky gut" plus low Vit B2 levels, then taking probiotics is going to cause the probiotic "good" bacteria to multiple in places outside of the GI tract, where it does not belong? That "leaky gut" in and of itself will cause problems with detoxification whether or not the person has any genetic influences affecting their ability to detox effectively?
In a nutshell, are you saying that someone like me who has gut problems and a lot of trouble detoxing most likely has "leaky gut" and taking probiotics are only making my problems worse? Should we stop taking probiotics? How can we close the gap on the leaky gut, if that is what we have? I've been on l-glutamine for 2.5 years now to "protect" me from leaky gut. What's the fix?
Astroman makes some great points.
location is often called a leaky gut. The pH change I refer to can often be countered by dietary intake. Sometimes, it takes more depending on what pathogens you are dealing with. Changing what you eat changes not only the pH but alters the ingredients that the bacteria utilize for food and reduces their numbers. More importantly, reducing their numbers coincides to altering bacterial ratios which helps with the dysbiosis.
If you have a leaky gut, probiotics can cause an increase in oxidative stress. The ultimate goal of the body is to retain blood pH and reduce oxidative stress. The body will sometimes do what seems like harmful things to achieve these goals.
IMO, a likely scenario is that you have pathogens in your blood/body and your immune response was causing too much oxidative stress when killing them. The leaky gut occurred to help reduce your peripheral pathogen load. A dysbiosis occurred and now you have problems in both places. Exercise or movement was vital for me. Increasing blood flow to the major ball and socket joints of the hips and shoulders did more than anything. Lifting weights was not required, just increasing blood flow was sufficient to reduce pathogen load. But that would only be half of the issue, the gut dysbiosis needs to be addressed. What pathogens are you dealing with? Like Astro said, fungi are almost always an issue. Studies show saccharomyces species (Florastor) increases immune response against other unwanted fungi like candida.
Yes, I would say many (if not all) on this forum have a leaky gut. Candida and too many gram negative anaerobes are often the problem, but staph or strep could be as well. Eating the correct foods is important as is reducing whatever pathogen(s) started this in the first place.
I unfortunately can't tell you what would work because I don't know. There are a lot of variables in play. For me, I went vegan for a month, juiced for a month, took every supplement known to man seeing what would happen, and now I only sleep 4 or 5 hours a night. I can do more but it is a lot of work and effort. Since I am living "normally," I'm just dealing with it. I don't hurt anymore, I can exercise, heck, I can walk more than 50 yards without having to rest. I'm totally different than I was but I'm also not as good as I once was. My brain is slipping and isn't anything like it was 5 or 10 years ago.
As for you, you have to increase the alkalinity of your GI tract some how. Alkaline foods and D-Limonene may work, I took it for some time. I liked Pectasol-C powder better, but it sure costs a lot more. In your situation, I would be thinking candida and intestinal parasites. They could perpetuate a dysbiosis of the GI tract.
What do you eat and drink?