Even Marshall Protocol uses small effective dosage. Effective because delivery "is made", without regard to amount. Are MIC's therefore irrellevant in lyme treatment?
Marshall Protocol uses Olmesartan first(as an macrophage activator) and insists on having low levels of anti-inflammatory hormone d25 second. As I see it, all antibiotics are out of the protocol, except for minocycline which is used as anti inflammatory.
New data regarding d25 levels:
Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074219/Elevated vitamin D3 level in vivo is associated with down-regulation of cytokine response through diminished surface expression of pattern recognition receptors(TLR2/TLR4).
Why TLRs are so important? Well...
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
Recognition of the array of pathogens though TLRs:
TLR4: Gram-negative bacteria, Pseudomonas aeruginosa, RSV, MMTV, Saccharomyces cerevisiae, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trypanosoma cruzi, Plasmodium falciprum, Toxoplasma gondii, Leishmania major, Entamoeba histolytica, Filarial nematode, Acanthocheilonema Viteae, Taenia crassiceps
TLR2: Gram-positive bacteria, Streptococcus B, Staphylococcus aureus, Trepanema maltophilum, Wolbachia, Borrelia burgdorferi
, Staphylococcus epidermidis, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Measles, Herpes, Saccharomyces cerevisiae, Candida albicans, Trypanosoma cruzi, Plasmodium falciprum, Toxoplasma gondii, Leishmania donovani, Leishmania major, Leishmana sp., Leishmania mexicana, Entamoeba histolytica, Ascaris lumbricoides, Schistosoma mansoni, Schistosoma japonicum, Taenia solium
TLR9 is also suppressed by D3 -> D25
and TLR9 is used to recognize bb:
Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells.
As for antibiotics - they work differently on MP than other protocols. Originally minocycline azithromycin clindamycin and Bactrim were used - all four active against intracellular white blood cell pathogens and in small doses to not interfere with immune system functioning much.
Post Edited (Dmitry) : 8/23/2018 5:43:15 AM (GMT-6)