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tonyaraven
Regular Member


Date Joined May 2017
Total Posts : 398
   Posted 11/16/2017 6:01 PM (GMT -6)   
Hi everyone, just curious if anyone is familiar with the Ispot lyme test, I did that one before the Igenex and it was negative, I was very discouraged at the time since all my symptoms seemed to point to Lyme. I was positive with Igenex for Lyme and Babesia. Maybe the Ispot isn't as accurate?

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 34669
   Posted 11/16/2017 6:32 PM (GMT -6)   
Tonyaraven - None of them are really accurate. Take the Igenex results and run with them.

Are you talking about Armin labs?

There are many false negatives...even with Igenex.

BUT the good news is you did get a positive result and you also know you have Babesia....no guessing on whether to treat that co-infection.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

astroman
Veteran Member


Date Joined Mar 2014
Total Posts : 5197
   Posted 11/16/2017 10:49 PM (GMT -6)   
There are two different labs performing this test. One in Wisconsin USA, (Neuroscience/Pharmasan labs) and one in Germany (I think so..name?).

I'm no expert on the USA version, but the i-spot is kinda odd, as it doesnt measure "bands" or antibodies. It provides you with two pieces of information:

1)It measures a reaction/strength of your bloods T cells subjected to their own culture(s) of lyme bacteria to somehow determine pos or neg. Apparently they proved anyone with active lyme has weak T cell strength. You have to have enough T cells for this test to work.

2)It also tells your T cell level / quantity compared to some range they determined is accurate among 400 non lyme people. The longer one has lyme, the less T cells in quantity you might have.

In the case of to low # of T cells, this means lyme itself is a possibility among only a few other things, some most likely still unknown.

Post Edited (astroman) : 11/16/2017 10:44:44 PM (GMT-7)


Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 34669
   Posted 11/16/2017 11:30 PM (GMT -6)   
Igenex now has an Immunoblot and an Ispot
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

tonyaraven
Regular Member


Date Joined May 2017
Total Posts : 398
   Posted 11/17/2017 12:27 AM (GMT -6)   
Thanks Girlie and Astroman for your feedback!

astroman
Veteran Member


Date Joined Mar 2014
Total Posts : 5197
   Posted 11/17/2017 12:43 AM (GMT -6)   
iSpot test post from 2015:

/www.healingwell.com/community/default.aspx?f=30&m=3557674
Ended ABX for Lyme in 2015. Rebuilding / repairing / fine tuning since then. What an adventure this has been.

astroman
Veteran Member


Date Joined Mar 2014
Total Posts : 5197
   Posted 11/17/2017 12:50 AM (GMT -6)   
New oct 2017:

Lyme IGX Spot

The Lyme IGXSpot is an Enzyme-Linked ImmunoSpot (ELISPOT) assay that detects human T cells reactive to B. burgdorferi-specific antigens in vitro. ELISPOT is a widely used method for detecting and monitoring cellular immune responses to specific antigens.
/www.lymedisease.org/igenex-new-tests-lyme-disease/

The Lyme IGX Spot test:

Detects specific T-cell responses soon after B. burgdorferi infection, when antibodies to the organisms are not detectable or late in the disease, when the levels of antibodies are very low.
When combined with Lyme ImmunoBlot tests, information on the full spectrum of patient’s immune response to infection and stage of disease is obtained.
Is especially useful for seronegative patients.

1000Daisies
Veteran Member


Date Joined Apr 2016
Total Posts : 2495
   Posted 11/17/2017 11:21 AM (GMT -6)   
We did an iSpot for Kid#2 through a NP. It was positive, but not a very strong positive. It was interpreted that lyme wasn't his biggest issue and coinfections may be more of his problem. This turned out to be very true for him. He didn't see much improvement at all doing lyme-related herbals, but he is definitely more reactive to the babesia/bartonella herbals. He also strongly reacts to the antiviral supplements too.

So, yes, we've used it once for Kid#2. One piece of the puzzle!!!
Kid#1: Extremely sick for several years, very difficult to treat, but doing great now!
Kid#2: Very sick now despite being treated for years, still very bad
Kid#3: Generally good but relapsing off/on.
Me: Adv Labs positive 2016 (suspected I passed to my kids)-not as sick as others, mostly battling fatigue and yeast issues (heart/kidney issues resolved)
Treating with herbals now.

tonyaraven
Regular Member


Date Joined May 2017
Total Posts : 398
   Posted 11/18/2017 12:50 AM (GMT -6)   
That would make since sense according to my ignex test my Lyme has not been a recent infection and I definitely react highly for any babesia treatment. It seems like Ignex is the most accurate.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 34669
   Posted 11/18/2017 1:25 PM (GMT -6)   
If you do the new Igenex test - will you post and let us know what the results are?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi
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