Hi bellabee123 -
After I typed my response below, I realized that I think I already responded to your similar question in another thread. But you band 39 is Lyme-specific immune response to Lyme, which means very few other things can cause that reaction.
So, in concert with band 41, you likely have a positive Lyme result. I explain below why the test tells you it's negative, which is really a false negative result and one of the reasons why studies show these tests are only about
In general immune system function terms, the IgM type of antibodies are developed by a healthy immune system when it first encounters something it doesn't like. So when tests detect IgM to something, it's interpreted as an immune response to an active/current, new or recent infection.
Typically, the IgM antibodies eventually transform into IgG antibodies, which generally stay with you for a very long time. So when IgG antibodies are detected for a specific infection, it's assumed that it was a previous infection and not necessarily current.
However, in the Lyme world - these "general rules" are not reliable. The Borrelia burgdorferi or Bb "Lyme" microbe has the capacity to evade and/or disable a normal immune response. This makes most of the "rules" unreliable and is also why many people do not produce enough antibodes IgM or IgG to register much detection on the serology tests being used by the medical system (ELISA or Western Blot).
But also, people like me who was tested 16+ yrs after I was infected, produce only or stronger IgM response over IgG. It makes no sense, but that's Lyme.
The CDC and testing labs will identify a test as negative if an insufficient number of specific IgM and IgG antibodies are produced. But as previously described, people with poor immune function simply aren't going to register enough antibodies for the tests to detect---which does NOT mean they do not have Lyme.
Also, the CDC's testing methodology and the specific criteria required to be met in order for the test to be positive, are developed for the CDC's surveillance protocol, NOT for diagnosing Lyme. Even the CDC states that MDs should not rely ONLY on test results - but that Lyme is a clinical diagnosis:"Surveillance case definitions establish uniform criteria for disease reporting and should not be used as the sole criteria for establishing clinical diagnoses, determining the standard of care necessary for a particular patient, setting guidelines for quality assurance, or providing standards for reimbursement." www.cdc.gov/lyme/stats/survfaq.html
Hope this is helpful -
LYME FORUM MODERATOR
Chronic late-stage lyme—likely infected in '98; Clinically dx Mar'14 w/ Babs, Fry Labs+ Bart-like, CDC+ Bb. First treated 4-5 viruses, GI/immune. Herbal antimicrobials in May; IV port-started Rocephin in Nov; added vancomycin Mar'16;
DETOX: Pinella/Burbur/Parsley/Milk thistle/Burdock/Red root; Samento/Banderol/Enula; JK/Turmeric; BFM-1; antifung; many supps; cholestyramine