Since I just deal with one person, I keep the med chart on the refrigerator near where I set out pills.
I use phone reminders and put the cycle schedule on the phone. It gets tough planning ahead if the kid or the family is going to be out of the house. I did have nurse at school doing 1 dose the first year.
I typically give kefir, probiotic, magnesium and multivitamin at bedtime and rest of supplements after school. Always give meds with meals (JC says that was fine) to avoid nausea - they said to ignore the milk warning labels and not worry about
dairy with meals (DS didn't have to do special diet). I never give vits or supplements with meds though.
Regarding school and meds timing - I realized last year that DS was having die-off 1-2 days after first monthly dose (actually he was sick most every Tuesday) so this year I asked if we could have day 1 be Friday rather than Monday so die-off would likely be Sat or Sun. That seems to be working. So we do Fri, Sun, Tues (plus Mon the first week). I would definitely try to track symptoms/CFS days for each kid so you can see trends and improvements over time. I did this on Xcel, daily at first but now 1x a month or if there's something to note - which is rare - yippee.
Parent of teen DS w/ CDC+ Lyme test Nov 2015, late stage Lyme + mycoplasma, bartonella, babesia. Currently treating with antibiotics/anti-malerials, multivitamin, magnesium, Charlotte's Web Advanced CBD oil.
Website I started: ParentsofLymeKids.com
aka Lyme Disease 101 for Parents