Baicalein for Lyme

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

LymeSick 🌟
Regular Member


Date Joined Aug 2017
Total Posts : 234
   Posted 12/15/2017 9:08 AM (GMT -6)   
Hey,

Has anyone tried this?

I came across this study:

We tested the efficacy of 15 phytochemicals and micronutrients against three morphological forms of Borrelia burgdoferi and Borrelia garinii: spirochetes, latent rounded forms and biofilm. The results showed that the most potent substances against the spirochete and rounded forms of B. burgdorferi and B. garinii were cis‐2‐decenoic acid, baicalein, monolaurin and kelp (iodine); whereas, only baicalein and monolaurin revealed significant activity against the biofilm. Moreover, cis‐2‐decenoic acid, baicalein and monolaurin did not cause statistically significant cytotoxicity to human HepG2 cells up to 125 μg ml−1 and kelp up to 20 μg ml−1.

/www.ncbi.nlm.nih.gov/pmc/articles/PMC4738477/

I did some research and found that Baicalein comes from Skullcap, confirming Buhner's research on this.

However, it seems that it's also possible to buy 95% pure Baicalein on Amazon. I wonder if that works any better than skullcap?

PeteZa
Veteran Member


Date Joined Jul 2015
Total Posts : 9729
   Posted 12/15/2017 10:44 AM (GMT -6)   
I think the whole premise of Buhner's protocol is synergy. He doesn't rely on one herb to do much really. It is the combo that he relies on. His protocol was made so all the herbs would be taken if possible.


But hey, why not give this a try?

Psilociraptor
Veteran Member


Date Joined Jul 2016
Total Posts : 1353
   Posted 12/15/2017 9:42 PM (GMT -6)   
Synergy is important. If you read the most recent study by that same author she showed that the combination of baicalein and luteolin dropped the minimum inhibitory concentration (MIC) of each from over 200-500ug/mL to something like 35ug/mL each which is a much more reasonable concentration to achieve in vivo (still not sure if it's sufficient though). Given that there are other bioactive flavenoids in skullcap alone there might be similar synergy within that plant alone, not to mention between it and other plants. However, I have to say I've been taking skullcap and it's not been any sort of miracle. I still need to give it more time and I think it's a good herb nonetheless but there are a lot of considerations here in regards to its direct antiborrelial action. Namely the comparative pharmacokinetics and dynamics of baicalein and its glycoside baicalin as well as how their ratios are affected by preparation methods. Ie which form of the flavenoid is the most desirable for disseminated borrelial infection, what is the best way to prepare it to increase the ratio of that form, is it possible to get it in high enough concentrations in the nervous system which is a suspected reservoir for reinfection, does it penetrate intracellular compartments, are the effects pH sensitive, etc. One of the reasons I prefer the whole herb approach is because it's like taking a shotgun to these sorts of problems.

PeteZa
Veteran Member


Date Joined Jul 2015
Total Posts : 9729
   Posted 12/15/2017 10:13 PM (GMT -6)   
Psilo you are so right. Shotgun versus bb gun.

borrelioburgdorferii
Regular Member


Date Joined Feb 2017
Total Posts : 246
   Posted 12/16/2017 6:02 AM (GMT -6)   
Yes bb. Just reacting to the conversation.

I have Baicalin, and I got it from Amazon. Yes it is essence of Skullcap and yes despite it's scary name, I think I found my way to it via Buhners protocol. My feeling is that it can't hurt, and it has been used in Eastern medicine for 1000s of years.

Was not aware of its efficacy on Biofilms, I recall it can alleviate pancreatitis and myriad other ailments.

I want to say it's good stuff, an adaptogen like Siberian Ginseng (eleuthero root powder) but don't quote me on that.

There has to be some scientific studies that are more specific about its mechanism of action such as anti-inflammatory, anti oxidant properties, and binding to GABA...
Bb+Co bite ~10+ years ago, bullseye rash
severe sleep apnea/restless leg syndrome/tachycardia/low grade fevers/migrating joint pain/myalgia/insomnia
neuropsych problems
Supplements
IgG via IgeneX 31-IND, 41++, 58+ (Sep-2016)
IgM via IgeneX 31+, 41-IND (Sep-2016)

Psilociraptor
Veteran Member


Date Joined Jul 2016
Total Posts : 1353
   Posted 12/16/2017 10:34 AM (GMT -6)   
"My feeling is that it can't hurt, and it has been used in Eastern medicine for 1000s of years. "

I just want to point out that skullcap has been used for thousands of years, not baicalein. While baicalein is a component of skullcap, like the synergy studies suggest, the efficacy of skullcap may be less dependent on baicalein than on it's complex mixture. In other words the effective dose of baicalein is potentially much smaller in its natural state than refined state leading to the possibility that side effects may be mitigated. That said, I believe from what I've read baicalein is fairly safe as a pharmaceutical. But just general speaking this is one of those reasons I don't recommend deriving the safety of an isolated compound from the safety of the herb. Other components of the herb may influence the absorption and distribution of a compound, it's metabolism, and may synergize or it's pharmacological activity.
New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, August 18, 2018 2:39 PM (GMT -6)
There are a total of 2,994,144 posts in 328,108 threads.
View Active Threads


Who's Online
This forum has 161260 registered members. Please welcome our newest member, MrLouies.
282 Guest(s), 12 Registered Member(s) are currently online.  Details
notsosicklygirl, suppwife, Kent M., Panamaeyes11, Gemlin, Girlie, Bob in Elkridge, KitKat880, nonames, quincy, Everton, ldog