MTHFR mutations - what significance do they have?

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Manzanita2
Regular Member


Date Joined May 2017
Total Posts : 127
   Posted 12/16/2017 6:00 PM (GMT -6)   
Sorry I'm posting again today but I just got back several test results and don't have an LLMD at the moment.

I just tested positive for the MTHFR mutations A1298C and C677T. I have a limited understanding of this. I know it does or can affect methylation or detox. I also regularly have slightly high homocysteine levels, which I think is related. I'm wondering if it would be helpful for me to take methylated folate. Or should I wait until I have a good doctor to discuss this with?

I've been treating herbally for Lyme and co-infections for about 5 months without a lot of progress. It seems as soon as I get even close to a full dose I have horrible herxing symptoms and have to stop and detox. Could the MTHFR gene have to do with this? Can anyone recommend any links to info on this?

Thanks!

PeteZa
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Date Joined Jul 2015
Total Posts : 9729
   Posted 12/16/2017 6:04 PM (GMT -6)   

Girlie
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Date Joined May 2014
Total Posts : 33899
   Posted 12/16/2017 6:23 PM (GMT -6)   
A couple of places that decipher: NutraHacker and GeneticGenie.


Here's a thread that may have some information:


/www.healingwell.com/community/default.aspx?f=30&m=3463631
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Manzanita2
Regular Member


Date Joined May 2017
Total Posts : 127
   Posted 12/16/2017 9:00 PM (GMT -6)   
Thanks so much Girlie and PeteZa. I guess I have a lot of reading to do.

I really hope knowing this will finally help me make some good progress toward healing.

doors12
Veteran Member


Date Joined Jul 2006
Total Posts : 716
   Posted 12/16/2017 10:31 PM (GMT -6)   
I take one half seeking health active b 12 lozenge (it has the methylfolate also) every other day, seems to work well
Positive test for lyme disease antibodies, brucella, babesia, bartonella, ehrlichia, mycoplasma, proteus mirabilis in 2015
~Pancolitis Ulcerative Colitis (Mild to Moderate) dx in 2006diagnosis changed to acute infectious colitis 2015
3/2014 heterozygous mthfr, several other mutations; chronic low vitamin D
massive success so far going gluten free on 1/2012!![

Georgia Hunter
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Date Joined May 2012
Total Posts : 2132
   Posted 12/17/2017 4:13 AM (GMT -6)   
A1298C mutations cause a lot of GI flora issues.

The Autism Pathways to Recovery reference in the 2nd link is the greatest reference or the best source of healing I've ever read. I've read it multiple times and still pick up on things every time I read it. I have it printed in a binder. Instead of autism, just think of it as treating Lyme or any condition for that matter.

The Dude Abides
Veteran Member


Date Joined May 2017
Total Posts : 1157
   Posted 12/17/2017 2:52 PM (GMT -6)   
For convenience, here's the link to "Autism: Pathways to Recovery" that Georgia Hunter mentioned:

Autism: Pathways to Recovery
Dr. Amy Yasko, Ph.D., CTN, NHD, AMD, HHP, FAAIM
www.dramyyasko.com/wp-content/files_flutter/1327512160_9_1_1_8_pdf_02_file.pdf

Manzanita2
Regular Member


Date Joined May 2017
Total Posts : 127
   Posted 12/17/2017 3:38 PM (GMT -6)   
Thanks for directing me to Pathways to Recovery! I really appreciate it. I’m reading it now. Lots of information. This is great. 🙂

Looks like I’m a compound heterozgous, having both of those mutations together. My report also says I have one called C699T as well. Apparently it has some significance, maybe having to do with ammonia.

I’d love to hear if any of you have these mutations and if you treat for them.

Post Edited (Manzanita2) : 12/17/2017 1:49:07 PM (GMT-7)


gabybee
Regular Member


Date Joined Nov 2015
Total Posts : 207
   Posted 12/17/2017 3:53 PM (GMT -6)   
I believe I am homozygous for these?

Not sure if doing my methylfolate 15 mg has done anything, but I take it daily.

When I first began taking it, I experienced a herx/detox reaction but I haven't gone off of it since. I assume it is helping and I'm not going to stop taking it anytime soon.
22 years old, symptoms started in 2013 and was diagnosed in 2015
HHV6/EBV
Lyme
Bartonella
MTHFR
ecoli+klebsiella
Candida

Treating with multiple vitamins + Supplements, Byron white formulas, and bee venom therapy.

The Dude Abides
Veteran Member


Date Joined May 2017
Total Posts : 1157
   Posted 12/17/2017 4:22 PM (GMT -6)   
Here are other resources from Dr. Amy Yasko that I learned about from Georgia Hunter:

Feel Good Nucleotides: feelgoodnucleotides.com
Feel Good Nutrigenomics: bit.ly/2zi8okG
Feel Good Biochemistry: feelgoodbiochem.com

Supplements, Nucleotide Products, Health Tests, and Books & DVDs: www.holisticheal.com

Georgia Hunter
Veteran Member


Date Joined May 2012
Total Posts : 2132
   Posted 12/18/2017 4:25 AM (GMT -6)   
Manzanita2 said...
Thanks for directing me to Pathways to Recovery! I really appreciate it. I’m reading it now. Lots of information. This is great. 🙂

Looks like I’m a compound heterozgous, having both of those mutations together. My report also says I have one called C699T as well. Apparently it has some significance, maybe having to do with ammonia.

I’d love to hear if any of you have these mutations and if you treat for them.


I have that mutation and eating less sulfur laden food is what has benefited me the most. I can handle the sulfur load in cruciferous vegetables but eating animal protein becomes problematic at some point. I no longer eat animal protein with every meal and in a perfect world, would only eat it once or twice a week in limited quantities.
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