Doxycycline resistance? If so, could Minocycline work?

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New Member

Date Joined Dec 2017
Total Posts : 12
   Posted 12/28/2017 1:00 PM (GMT -6)   
Hello all!

I know there are no or very limited research indicating that Lyme disease can become resistant to Doxycycline. However, for me it feels exactly like this. I used a too low dosage (300 mg, also sometimes taken close to when I had cheese) for 4 weeks. It worked great in the first two weeks, my symptoms disappeared in three days (burning/tingling in face and feet) and only had some headache now and then left. All my energy back. However, after two weeks unfortunately I forgot to take the pills one day and also slept bad. After this my symptoms returned and further treatment with Doxycycline did not work.

After this I had a break of three days and then got prescribed 400 mg Doxycycline for two weeks. During this period I started to get many new symptoms, the worst being brain fog and back pain but also shaking fingers. I also got a lot of anxiety and depression. I stopped after two weeks since it was only making me worse, I could not imagine it was only Herx reactions.

So, if I have become resistant to Doxycycline, could Minocycline work instead even though it is also part of the Tetracycline family? This is important because it influences at which clinic I should be treated (BCA or Vital Klinik). I have an option where you get IV Clarithromycin (as the only antibiotic) and this sounds a bit interesting since it is part of a completely different antibiotic family.

Thank you a lot in advance, any help is useful!

Post Edited (Jamtland) : 12/28/2017 11:03:07 AM (GMT-7)

Forum Moderator

Date Joined May 2014
Total Posts : 33899
   Posted 12/28/2017 1:27 PM (GMT -6)   
I'm not sure you're experiencing resistance.

When you took the 400 mg after the break and you got new symptoms, it does sound like a herx to me.

Even if it was resistant to doxycycline...I don't think it would be to the minocycline.

You don't want to take just one antibiotic. Mono therapy is not recommended. You need to always be taking 2 or more.

Also, maybe it's a co-infection that is causing the new symptoms. Bartonella and Babesia need to be addressed in most cases.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Veteran Member

Date Joined Mar 2014
Total Posts : 1664
   Posted 12/28/2017 2:11 PM (GMT -6)   
I second what Girlie said on the doxy resistance and dosage. If you are early in treatment maybe you are due for a change anyway. A good combo of Zith and Omnicef may help, but start with one first then add the second a few days to a week later.

Veteran Member

Date Joined Jun 2015
Total Posts : 2922
   Posted 12/28/2017 11:40 PM (GMT -6)   
highly highly doubtful the bugs have resistance to doxy from so short a stint let alone at all. you are experiencing what most do that is ebbs and flow of symptom severity and new ones coming out over time as you treat. this is perfectly normal (as screwed up as that sounds) in this world of treating these bugs.
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