reliability of the DNA Connexions test?

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LilyPanda
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Date Joined Jun 2016
Total Posts : 55
   Posted 1/8/2018 12:11 PM (GMT -6)   
I've looked at some other posts here about the DNA Connexions test, but I'm still unsure about whether it's considered reliable and accurate. Does anyone have thoughts on this?

My results were listed as:

Babesia divergens - NPS
Borrelia recurrentis - NPS
Ehrlichia chaffeensis - NPS

The NP who gave the results didn't really explain them. The one-page test result indicates that "NPS" (non-predictive size) is described as meaning: "Species specific DNA was detected but amplification product was not of expected size. More commonly seen in individuals with long-term infections. Product size differential possibly due to: mutation of species, unspecified subspecies, other."

I'm also confused because, when I google Borrelia recurrentis, I see that it "most commonly occurs in conditions of overcrowding and social disruption" (such as areas in sub-Saharan Africa that are affected by war and in refugee camps) -- and that it is transmitted by the body louse. I live in NYC and have never traveled to any area that meets this description (much less to any area where body lice was an issue). This causes me some doubt as to the accuracy of this test.
Started herbal treatment for Lyme in early 2017. Did 1 month of doxy Aug. 2017; started doxy again Jan. 2018. Uncertain about diagnosis b/c tests have been iffy, and my symptoms (dry eyes/mouth, finger joint pain/swelling) look like classic autoimmune issues. DNA Connexions test showed Lyme, babesia, ehrlichia. Rheumatologist doesn't believe in these test results.

Post Edited (LilyPanda) : 1/8/2018 12:09:36 PM (GMT-7)


Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 337
   Posted 1/8/2018 12:32 PM (GMT -6)   
I do not know anything about the DNA Connexions test.

I am very weary of the quality of information out there for Borrelia. I do not believe the medical community has a good grasp of Borrelia prevalence, vectors, or transmission.

I do not see how they make these finite statements on these variants of Rickettsia and Borrelia when there are new Lyme pathogens being discovered every year. There are so many that they know absolutely nothing about- B. Mayoni, Rikkettsia Montanensis, B bisettii. I am not sure about Borrelia recurrentis, but I don't think the medical community is either.

They act like they have every aspect of this nailed down with their shoot from the hip statements and lack of investigative science.

k07
Veteran Member


Date Joined Sep 2015
Total Posts : 2502
   Posted 1/8/2018 1:39 PM (GMT -6)   
I would suggest calling dna connexions - they are pretty helpful with questions.

cakegirl
Regular Member


Date Joined Nov 2016
Total Posts : 254
   Posted 1/8/2018 5:38 PM (GMT -6)   
Has anyone ever tested negative via this test? It seems like everyone who's posted about this test was given "positive" results.

WalkingbyFaith
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Date Joined Aug 2017
Total Posts : 1682
   Posted 1/8/2018 5:54 PM (GMT -6)   
My doctor explained if you test positive with DNA Connexions, the accuracy is 100%. It's a PCR analysis looking for bacterial DNA in your sample. If they find any bacterial DNA, then the result is positive. If you have a negative test result with DNA Connexions, it is not proof that you do not have that infection. It only means they did not find that bacterial infection in the sample you sent them.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32635
   Posted 1/8/2018 6:45 PM (GMT -6)   
cakegirl said...
Has anyone ever tested negative via this test? It seems like everyone who's posted about this test was given "positive" results.


Yes, there is a member who did test negative...can't remember who it was though.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

mm57553
Veteran Member


Date Joined Jan 2017
Total Posts : 543
   Posted 1/9/2018 9:08 AM (GMT -6)   
It means you have those things listed. You wouldn't have the DNA for them in your system if you didn't. I tested positive for borrelia recurrentis too. It's actually a pretty common strain (Dr. Horowitz discusses it), so it's not only found in other areas of the world.

I think DNA Connexions is one of the more accurate tests. The NSA results could mean it's a long-standing infection (you've had it for a while) or it's also possible that the test was not stimulated enough (i.e. the deep tissue massage was not aggressive enough or you did not exercise vigorously enough) beforehand.

k07
Veteran Member


Date Joined Sep 2015
Total Posts : 2502
   Posted 1/9/2018 9:26 AM (GMT -6)   
I was fully negative on it.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32635
   Posted 1/9/2018 12:58 PM (GMT -6)   
k07 said...
I was fully negative on it.


You came to mind...but I wasn't positive...so didn't want to post.



Thanks for posting k07
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

k07
Veteran Member


Date Joined Sep 2015
Total Posts : 2502
   Posted 1/9/2018 1:02 PM (GMT -6)   
Piourette was negative as well.
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